Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029090752> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2029090752 endingPage "883" @default.
- W2029090752 startingPage "878" @default.
- W2029090752 abstract "The aim of this study was to examine the outcome, adverse events and clinical complications of long-term chemotherapy with pegylated liposomal doxorubicin (PegLiposomal DOX) for human immunodeficiency virus (HIV)-associated Kaposi's sarcoma (KS) in the pre-highly active antiretroviral therapy (HAART) era. A phase II study over a 4-year period in a tertiary care university hospital was carried out. 52 acquired immunodeficiency syndrome (AIDS)-patients with advanced KS received long-term chemotherapy (71+/-51 weeks) with a mean of 22.8+/-18.2 cycles and a mean cumulative liposomal doxorubicin dose of 456+/-364 mg/m(2) (120-1040 mg/m(2)). Tumour burden, duration and dosage of PegLiposomal DOX, adverse events, opportunistic infections, immunological parameters and HIV load were measured. A complete (10%) or partial response (56%) was achieved while on chemotherapy. 10 patients (19%) showed stable disease. Tumour progression was observed in 8 patients (15%). Importantly, chemotherapy with PegLiposomal DOX was also successful after previous cytostatic therapy with bleomycin and vincristine. The most common adverse events included leucopenia, neutropenia, anaemia, and increased liver function tests. 34 patients (65%) developed new opportunistic infections and 29 patients (56%) died during the study period. To conclude, pegylated liposomal doxorubicin is a safe and effective drug for long-term chemotherapy of advanced (AIDS) KS without adverse effects on CD4 cell counts and HIV viral load." @default.
- W2029090752 created "2016-06-24" @default.
- W2029090752 creator A5017456073 @default.
- W2029090752 creator A5042504464 @default.
- W2029090752 creator A5048845294 @default.
- W2029090752 creator A5077785097 @default.
- W2029090752 date "2001-05-01" @default.
- W2029090752 modified "2023-09-27" @default.
- W2029090752 title "Long-term chemotherapy of HIV-associated Kaposi's sarcoma with liposomal doxorubicin" @default.
- W2029090752 cites W1490119519 @default.
- W2029090752 cites W1918322381 @default.
- W2029090752 cites W1966172935 @default.
- W2029090752 cites W1975298683 @default.
- W2029090752 cites W1986859702 @default.
- W2029090752 cites W2027744948 @default.
- W2029090752 cites W2031107591 @default.
- W2029090752 cites W2032438721 @default.
- W2029090752 cites W2047243599 @default.
- W2029090752 cites W2059059770 @default.
- W2029090752 cites W2059427717 @default.
- W2029090752 cites W2120107087 @default.
- W2029090752 cites W2131364552 @default.
- W2029090752 cites W2136526938 @default.
- W2029090752 cites W2165837635 @default.
- W2029090752 cites W2169253572 @default.
- W2029090752 cites W298819183 @default.
- W2029090752 doi "https://doi.org/10.1016/s0959-8049(01)00053-3" @default.
- W2029090752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11313176" @default.
- W2029090752 hasPublicationYear "2001" @default.
- W2029090752 type Work @default.
- W2029090752 sameAs 2029090752 @default.
- W2029090752 citedByCount "42" @default.
- W2029090752 countsByYear W20290907522013 @default.
- W2029090752 countsByYear W20290907522014 @default.
- W2029090752 countsByYear W20290907522015 @default.
- W2029090752 countsByYear W20290907522017 @default.
- W2029090752 countsByYear W20290907522018 @default.
- W2029090752 countsByYear W20290907522019 @default.
- W2029090752 countsByYear W20290907522020 @default.
- W2029090752 countsByYear W20290907522021 @default.
- W2029090752 countsByYear W20290907522023 @default.
- W2029090752 crossrefType "journal-article" @default.
- W2029090752 hasAuthorship W2029090752A5017456073 @default.
- W2029090752 hasAuthorship W2029090752A5042504464 @default.
- W2029090752 hasAuthorship W2029090752A5048845294 @default.
- W2029090752 hasAuthorship W2029090752A5077785097 @default.
- W2029090752 hasConcept C126322002 @default.
- W2029090752 hasConcept C141071460 @default.
- W2029090752 hasConcept C142462285 @default.
- W2029090752 hasConcept C142724271 @default.
- W2029090752 hasConcept C197934379 @default.
- W2029090752 hasConcept C203014093 @default.
- W2029090752 hasConcept C2776232574 @default.
- W2029090752 hasConcept C2776694085 @default.
- W2029090752 hasConcept C2776755627 @default.
- W2029090752 hasConcept C2777063308 @default.
- W2029090752 hasConcept C2778256501 @default.
- W2029090752 hasConcept C2779429289 @default.
- W2029090752 hasConcept C2781303535 @default.
- W2029090752 hasConcept C3013748606 @default.
- W2029090752 hasConcept C71924100 @default.
- W2029090752 hasConcept C90924648 @default.
- W2029090752 hasConceptScore W2029090752C126322002 @default.
- W2029090752 hasConceptScore W2029090752C141071460 @default.
- W2029090752 hasConceptScore W2029090752C142462285 @default.
- W2029090752 hasConceptScore W2029090752C142724271 @default.
- W2029090752 hasConceptScore W2029090752C197934379 @default.
- W2029090752 hasConceptScore W2029090752C203014093 @default.
- W2029090752 hasConceptScore W2029090752C2776232574 @default.
- W2029090752 hasConceptScore W2029090752C2776694085 @default.
- W2029090752 hasConceptScore W2029090752C2776755627 @default.
- W2029090752 hasConceptScore W2029090752C2777063308 @default.
- W2029090752 hasConceptScore W2029090752C2778256501 @default.
- W2029090752 hasConceptScore W2029090752C2779429289 @default.
- W2029090752 hasConceptScore W2029090752C2781303535 @default.
- W2029090752 hasConceptScore W2029090752C3013748606 @default.
- W2029090752 hasConceptScore W2029090752C71924100 @default.
- W2029090752 hasConceptScore W2029090752C90924648 @default.
- W2029090752 hasIssue "7" @default.
- W2029090752 hasLocation W20290907521 @default.
- W2029090752 hasLocation W20290907522 @default.
- W2029090752 hasOpenAccess W2029090752 @default.
- W2029090752 hasPrimaryLocation W20290907521 @default.
- W2029090752 hasRelatedWork W1952212414 @default.
- W2029090752 hasRelatedWork W1973158710 @default.
- W2029090752 hasRelatedWork W1983592577 @default.
- W2029090752 hasRelatedWork W2059273049 @default.
- W2029090752 hasRelatedWork W2397738413 @default.
- W2029090752 hasRelatedWork W2399940321 @default.
- W2029090752 hasRelatedWork W2415370280 @default.
- W2029090752 hasRelatedWork W2424848057 @default.
- W2029090752 hasRelatedWork W2519000420 @default.
- W2029090752 hasRelatedWork W298819183 @default.
- W2029090752 hasVolume "37" @default.
- W2029090752 isParatext "false" @default.
- W2029090752 isRetracted "false" @default.
- W2029090752 magId "2029090752" @default.
- W2029090752 workType "article" @default.