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• W2029097259 abstract "Myelin proteins, including myelin basic protein (MBP), proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) are candidate autoantigens in MS. It is not clear whether MS patients show a predominant reactivity to one or several myelin antigens. We evaluated the IFN-γ production induced by MBP and MOG and selected MBP-, MOG- and PLP-peptides in MS patients and healthy controls using the IFN-γ ELISPOT assay. Most MS patients and healthy controls showed a heterogeneous anti-myelin T-cell reactivity. Interestingly in MS patients a positive correlation was found between the anti-MOG and anti-MBP T-cell responses. No myelin peptide was preferentially recognized among the peptides tested (MBP 84–102, 143–168, MOG 1–22, 34–56, 64–86, 74–96, PLP 41–58, 184–199, 190–209). In addition the frequency of IL2R+ MBP reactive T-cells was significantly increased in blood of MS patients as compared with healthy subjects, indicating that MBP reactive T-cells exist in an in vivo activated state in MS patients. Most of the anti-MBP T-cells were of the Th1-type because reactivity was observed in IFN-γ but not in IL-4 ELISPOT-assays. Using Th1 (IL-12) and Th2 (IL-4) promoting conditions we observed that the cytokine secretion pattern of anti-MBP T-cells still is susceptible to alteration. Our data further indicate that precursor frequency analysis of myelin reactive T-cells by proliferation-based assays may underestimate the true frequency of myelin specific T-cells significantly. J. Neurosci. Res. 63:290–302, 2001. © 2001 Wiley-Liss, Inc." @default.
• W2029097259 created "2016-06-24" @default.
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• W2029097259 date "2001-01-01" @default.
• W2029097259 modified "2023-09-25" @default.
• W2029097259 title "T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls" @default.
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• W2029097259 doi "https://doi.org/10.1002/1097-4547(20010201)63:3<290::aid-jnr1023>3.0.co;2-4" @default.
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