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• W2029102082 endingPage "196" @default.
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• W2029102082 abstract "The Y-box protein-1 (YB-1) belongs to the family of cold shock proteins that have pleiotropic functions such as gene transcription, RNA splicing, and mRNA translation. YB-1 has a critical role in atherogenesis due to its regulatory effects on chemokine CCL5 (RANTES) gene transcription in vascular smooth muscle cells. Since CCL5 is a key mediator of kidney transplant rejection, we determined whether YB-1 is involved in allograft rejection by manipulating its expression. In human kidney biopsies, YB-1 transcripts were amplified 17-fold in acute and 21-fold in chronic allograft rejection with a close correlation between CCL5 and YB-1 mRNA expression in both conditions. Among three possible YB-1 binding sites in the CCL5 promoter, a critical element was mapped at -28/-10 bps. This site allowed up-regulation of CCL5 transcription in monocytic THP-1 and HUT78 T-cells and in human primary monocytes; however, it repressed transcription in differentiated macrophages. Conversely, YB-1 knockdown led to decreased CCL5 transcription and secretion in monocytic cells. We show that YB-1 is a cell-type specific regulator of CCL5 expression in infiltrating T-cells and monocytes/macrophages and acts as an adaptive controller of inflammation during kidney allograft rejection." @default.
• W2029102082 created "2016-06-24" @default.
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• W2029102082 date "2009-01-01" @default.
• W2029102082 modified "2023-10-03" @default.
• W2029102082 title "Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1" @default.
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• W2029102082 doi "https://doi.org/10.1038/ki.2008.457" @default.
• W2029102082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18800033" @default.
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