FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029115752> ?p ?o ?g. }

• W2029115752 endingPage "383" @default.
• W2029115752 startingPage "373" @default.
• W2029115752 abstract "In this study we used immunohistochemistry and two-dimensional fingerprinting of oxidatively modified proteins (two-dimensional Oxyblot) together to investigate protein carbonyl formation in the Alzheimer's disease brain. Increased protein oxidation was detected in sections from the hippocampus and parahippocampal gyrus, superior and middle temporal gyri of six Alzheimer's disease and six age-matched control human subjects, but not in the cerebellum. In two brain regions severely affected by Alzheimer's disease pathology, prominent protein carbonyl immunoreactivity was localized in the cytoplasm of neurons without visual pathomorphological changes and degenerating neurons, suggesting that intracellular proteins might be significantly affected by oxidative modifications. Following two-dimensional electrophoresis the positions of some individual proteins were identified using specific antibodies, and immunoblot analysis for protein carbonyls was performed. These studies demonstrated the presence of protein carbonyl immunoreactivity in beta-tubulin, beta-actin and creatine kinase BB in Alzheimer's disease and control brain extracts. Protein carbonyls were undetectable in spots matching glial fibrillary acidic protein and tau isoforms. Specific protein carbonyl levels in beta-actin and creatine kinase BB were significantly higher in Alzheimer's disease than in control brain extract. beta-Tubulin did not demonstrate a significant increase in specific protein carbonyl content in Alzheimer's disease brains. We suggest that oxidative stress-induced injury may involve the selective modification of different intracellular proteins, including key enzymes and structural proteins, which precedes and may lead to the neurofibrillary degeneration of neurons in the Alzheimer's disease brain." @default.
• W2029115752 created "2016-06-24" @default.
• W2029115752 creator A5002075424 @default.
• W2029115752 creator A5003994463 @default.
• W2029115752 creator A5008788895 @default.
• W2029115752 creator A5015362684 @default.
• W2029115752 creator A5065589335 @default.
• W2029115752 date "2001-03-01" @default.
• W2029115752 modified "2023-10-11" @default.
• W2029115752 title "Protein oxidation in the brain in Alzheimer's disease" @default.
• W2029115752 cites W1501293323 @default.
• W2029115752 cites W1508162082 @default.
• W2029115752 cites W1577069180 @default.
• W2029115752 cites W1577502769 @default.
• W2029115752 cites W1584774790 @default.
• W2029115752 cites W1662308449 @default.
• W2029115752 cites W1759706356 @default.
• W2029115752 cites W1966614543 @default.
• W2029115752 cites W1973526079 @default.
• W2029115752 cites W1973575384 @default.
• W2029115752 cites W1975481911 @default.
• W2029115752 cites W1986003135 @default.
• W2029115752 cites W1986687712 @default.
• W2029115752 cites W1987355392 @default.
• W2029115752 cites W1987741979 @default.
• W2029115752 cites W1988507091 @default.
• W2029115752 cites W1996766499 @default.
• W2029115752 cites W1998179320 @default.
• W2029115752 cites W2001033190 @default.
• W2029115752 cites W2001628753 @default.
• W2029115752 cites W2013764865 @default.
• W2029115752 cites W2013864534 @default.
• W2029115752 cites W2013936759 @default.
• W2029115752 cites W2014070897 @default.
• W2029115752 cites W2026851735 @default.
• W2029115752 cites W2027189256 @default.
• W2029115752 cites W2031654442 @default.
• W2029115752 cites W2036451354 @default.
• W2029115752 cites W2042628846 @default.
• W2029115752 cites W2049192526 @default.
• W2029115752 cites W2049262684 @default.
• W2029115752 cites W2054706594 @default.
• W2029115752 cites W2063195487 @default.
• W2029115752 cites W2069787626 @default.
• W2029115752 cites W2073516240 @default.
• W2029115752 cites W2084833093 @default.
• W2029115752 cites W2087292928 @default.
• W2029115752 cites W2093232497 @default.
• W2029115752 cites W2094466584 @default.
• W2029115752 cites W2100610042 @default.
• W2029115752 cites W2100837269 @default.
• W2029115752 cites W2122065036 @default.
• W2029115752 cites W2137023025 @default.
• W2029115752 cites W2146729934 @default.
• W2029115752 cites W2156220037 @default.
• W2029115752 cites W2165021720 @default.
• W2029115752 cites W2170356535 @default.
• W2029115752 cites W2725718031 @default.
• W2029115752 cites W4231853230 @default.
• W2029115752 cites W53696959 @default.
• W2029115752 cites W9996517 @default.
• W2029115752 doi "https://doi.org/10.1016/s0306-4522(00)00580-7" @default.
• W2029115752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11246152" @default.
• W2029115752 hasPublicationYear "2001" @default.
• W2029115752 type Work @default.
• W2029115752 sameAs 2029115752 @default.
• W2029115752 citedByCount "466" @default.
• W2029115752 countsByYear W20291157522012 @default.
• W2029115752 countsByYear W20291157522013 @default.
• W2029115752 countsByYear W20291157522014 @default.
• W2029115752 countsByYear W20291157522015 @default.
• W2029115752 countsByYear W20291157522016 @default.
• W2029115752 countsByYear W20291157522017 @default.
• W2029115752 countsByYear W20291157522018 @default.
• W2029115752 countsByYear W20291157522019 @default.
• W2029115752 countsByYear W20291157522020 @default.
• W2029115752 countsByYear W20291157522021 @default.
• W2029115752 countsByYear W20291157522022 @default.
• W2029115752 countsByYear W20291157522023 @default.
• W2029115752 crossrefType "journal-article" @default.
• W2029115752 hasAuthorship W2029115752A5002075424 @default.
• W2029115752 hasAuthorship W2029115752A5003994463 @default.
• W2029115752 hasAuthorship W2029115752A5008788895 @default.
• W2029115752 hasAuthorship W2029115752A5015362684 @default.
• W2029115752 hasAuthorship W2029115752A5065589335 @default.
• W2029115752 hasConcept C134018914 @default.
• W2029115752 hasConcept C142724271 @default.
• W2029115752 hasConcept C153911025 @default.
• W2029115752 hasConcept C185592680 @default.
• W2029115752 hasConcept C204232928 @default.
• W2029115752 hasConcept C2778670691 @default.
• W2029115752 hasConcept C2779134260 @default.
• W2029115752 hasConcept C2779652256 @default.
• W2029115752 hasConcept C2780495277 @default.
• W2029115752 hasConcept C502032728 @default.
• W2029115752 hasConcept C55493867 @default.
• W2029115752 hasConcept C71924100 @default.
• W2029115752 hasConcept C86803240 @default.

• next