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• W2029117730 abstract "CD37 is cell surface tetraspanin present on normal and malignant B cells. Otlertuzumab (TRU-016) is a novel humanized anti-CD37 protein therapeutic. Patients with relapsed or refractory follicular non-Hodgkin lymphoma (FL), mantle cell lymphoma (MCL), or Waldenström's macroglobulinaemia (WM) received otlertuzumab at 20 mg/kg administered intravenously once a week for up to 8 weeks followed by 4 monthly doses. Sixteen patients were treated; median age was 62·5 years (range, 41–81), and median number of prior regimens was 4 (range, 1–7). Twelve patients were refractory to prior treatment, 5 were refractory to rituximab. The mean terminal half-life was 9·5 days. Lymph node reduction of ≥50% by computerized tomography scan measurements was seen in 3 of 12 patients, including one FL patient who had a partial response. One WM patient had a minor response. The most frequent adverse events were neutropenia, fatigue, nausea, thrombocytopenia, diarrhoea, and peripheral oedema; most were grade 1/2. Otlertuzumab treatment appears to have been well tolerated by the patients in this study. Clinical activity was observed in this small heterogeneous cohort of highly refractory, heavily pretreated B-cell non-Hodgkin lymphoma patients. These data suggest that further clinical investigation in non-Hodgkin lymphoma is warranted." @default.
• W2029117730 created "2016-06-24" @default.
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• W2029117730 date "2014-08-22" @default.
• W2029117730 modified "2023-10-12" @default.
• W2029117730 title "Otlertuzumab ( <scp>TRU</scp> ‐016), an anti‐ <scp>CD</scp> 37 monospecific <scp>ADAPTIR</scp> ^™ therapeutic protein, for relapsed or refractory <scp>NHL</scp> patients" @default.
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• W2029117730 doi "https://doi.org/10.1111/bjh.13099" @default.
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