FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029121477> ?p ?o ?g. }

• W2029121477 endingPage "339" @default.
• W2029121477 startingPage "331" @default.
• W2029121477 abstract "This study addresses the question of whether human peripheral CD4+ CD45RA+ T cells possess antigen-specific immune memory. CD4+ CD45RA+ T cells were isolated by a combination of positive and negative selection. Putative CD4+ CD45RA+ cells expressed CD45RA (98.9%) and contained < 0.1% CD4+ CD45RO+ and < 0.5% CD4+ CD45RA+ CD45RO+ cells. Putative CD45RO+ cells expressed CD45RO (90%) and contained 9% CD45RA+ CD45RO+ and < 0.1% CD4+ CD45RA+ cells. The responder frequency of Dermatophagoides pteronyssinus-stimulated CD4+ CD45RA+ and CD4+ CD45RO+ T cells was determined in two atopic donors and found to be 1:11,314 and 1:8031 for CD4+ CD45RA+ and 1:1463 and 1:1408 for CD4+ CD45RO+ T cells. The responder frequencies of CD4+ CD45RA+ and CD4+ CD45RO+ T cells from two non-atopic, but exposed, donors were 1:78031 and 1:176,903 for CD4+ CD45RA+ and 1:9136 and 1:13,136 for CD4+ CD45RO+ T cells. T cells specific for D. pteronyssinus were cloned at limiting dilution following 10 days of bulk culture with D. pteronyssinus antigen. Sixty-eight clones were obtained from CD4+ CD45RO+ and 24 from CD4+ CD45RA+ T cells. All clones were CD3+ CD4+ CD45RO+ and proliferated in response to D. pteronyssinus antigens. Of 40 clones tested, none responded to Tubercule bacillus purified protein derivative (PPD). No difference was seen in the pattern of interleukin-4 (IL-4) or interferon-gamma (IFN-gamma) producing clones derived from CD4+ CD45RA+ and CD4+ CD45RO+ precursors, although freshly isolated and polyclonally activated CD4+ CD45RA+ T cells produced 20-30-fold lower levels of IL-4 and IFN-gamma than their CD4+ CD45RO+ counterparts. Sixty per cent of the clones used the same pool of V beta genes. These data support the hypothesis that immune memory resides in CD4+ CD45RA+ as well as CD4+ CD45RO+ T cells during the chronic immune response to inhaled antigen." @default.
• W2029121477 created "2016-06-24" @default.
• W2029121477 creator A5000957116 @default.
• W2029121477 creator A5006695127 @default.
• W2029121477 creator A5038348648 @default.
• W2029121477 creator A5062439254 @default.
• W2029121477 creator A5076713454 @default.
• W2029121477 date "1997-07-01" @default.
• W2029121477 modified "2023-09-23" @default.
• W2029121477 title "Immune memory in CD4+ CD45RA+ T cells" @default.
• W2029121477 cites W1497403634 @default.
• W2029121477 cites W1539987334 @default.
• W2029121477 cites W1545996553 @default.
• W2029121477 cites W1662062366 @default.
• W2029121477 cites W1962521045 @default.
• W2029121477 cites W1969596278 @default.
• W2029121477 cites W1970038233 @default.
• W2029121477 cites W1973684380 @default.
• W2029121477 cites W1999168221 @default.
• W2029121477 cites W2000714511 @default.
• W2029121477 cites W2004881110 @default.
• W2029121477 cites W2022276852 @default.
• W2029121477 cites W2025264316 @default.
• W2029121477 cites W2025622872 @default.
• W2029121477 cites W2037692840 @default.
• W2029121477 cites W2043955812 @default.
• W2029121477 cites W2047125790 @default.
• W2029121477 cites W2049216747 @default.
• W2029121477 cites W2071967617 @default.
• W2029121477 cites W2072616902 @default.
• W2029121477 cites W2075627822 @default.
• W2029121477 cites W2076639290 @default.
• W2029121477 cites W2077720595 @default.
• W2029121477 cites W2078787648 @default.
• W2029121477 cites W2105706890 @default.
• W2029121477 cites W2125671909 @default.
• W2029121477 cites W2127800073 @default.
• W2029121477 cites W2136536421 @default.
• W2029121477 cites W2137266943 @default.
• W2029121477 cites W2137384756 @default.
• W2029121477 cites W2140202337 @default.
• W2029121477 cites W2148837825 @default.
• W2029121477 cites W2419561211 @default.
• W2029121477 cites W30334389 @default.
• W2029121477 cites W4210866193 @default.
• W2029121477 doi "https://doi.org/10.1046/j.1365-2567.1997.00274.x" @default.
• W2029121477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1364000" @default.
• W2029121477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9301520" @default.
• W2029121477 hasPublicationYear "1997" @default.
• W2029121477 type Work @default.
• W2029121477 sameAs 2029121477 @default.
• W2029121477 citedByCount "32" @default.
• W2029121477 countsByYear W20291214772015 @default.
• W2029121477 countsByYear W20291214772022 @default.
• W2029121477 countsByYear W20291214772023 @default.
• W2029121477 crossrefType "journal-article" @default.
• W2029121477 hasAuthorship W2029121477A5000957116 @default.
• W2029121477 hasAuthorship W2029121477A5006695127 @default.
• W2029121477 hasAuthorship W2029121477A5038348648 @default.
• W2029121477 hasAuthorship W2029121477A5062439254 @default.
• W2029121477 hasAuthorship W2029121477A5076713454 @default.
• W2029121477 hasBestOaLocation W20291214772 @default.
• W2029121477 hasConcept C114684123 @default.
• W2029121477 hasConcept C129374314 @default.
• W2029121477 hasConcept C147483822 @default.
• W2029121477 hasConcept C149532602 @default.
• W2029121477 hasConcept C153911025 @default.
• W2029121477 hasConcept C154317977 @default.
• W2029121477 hasConcept C167672396 @default.
• W2029121477 hasConcept C202751555 @default.
• W2029121477 hasConcept C203014093 @default.
• W2029121477 hasConcept C2992881475 @default.
• W2029121477 hasConcept C55493867 @default.
• W2029121477 hasConcept C86803240 @default.
• W2029121477 hasConcept C8891405 @default.
• W2029121477 hasConceptScore W2029121477C114684123 @default.
• W2029121477 hasConceptScore W2029121477C129374314 @default.
• W2029121477 hasConceptScore W2029121477C147483822 @default.
• W2029121477 hasConceptScore W2029121477C149532602 @default.
• W2029121477 hasConceptScore W2029121477C153911025 @default.
• W2029121477 hasConceptScore W2029121477C154317977 @default.
• W2029121477 hasConceptScore W2029121477C167672396 @default.
• W2029121477 hasConceptScore W2029121477C202751555 @default.
• W2029121477 hasConceptScore W2029121477C203014093 @default.
• W2029121477 hasConceptScore W2029121477C2992881475 @default.
• W2029121477 hasConceptScore W2029121477C55493867 @default.
• W2029121477 hasConceptScore W2029121477C86803240 @default.
• W2029121477 hasConceptScore W2029121477C8891405 @default.
• W2029121477 hasIssue "3" @default.
• W2029121477 hasLocation W20291214771 @default.
• W2029121477 hasLocation W20291214772 @default.
• W2029121477 hasLocation W20291214773 @default.
• W2029121477 hasOpenAccess W2029121477 @default.
• W2029121477 hasPrimaryLocation W20291214771 @default.
• W2029121477 hasRelatedWork W1505145311 @default.
• W2029121477 hasRelatedWork W1998909668 @default.
• W2029121477 hasRelatedWork W2003236386 @default.
• W2029121477 hasRelatedWork W2018916009 @default.

• next