FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029121484> ?p ?o ?g. }

• W2029121484 endingPage "556" @default.
• W2029121484 startingPage "548" @default.
• W2029121484 abstract "Aggregation levels of therapeutic proteins may be difficult to determine in mixtures containing other proteinaceous excipients. We performed a feasibility study of using serial coupling of an anion exchange and size exclusion column to determine the aggregation levels of four different model monoclonal antibodies (mAb) mixed with the model proteinaceous excipient recombinant human serum albumin (rHSA). For three of the four mAbs suitable elution conditions could be established. From the limitations imposed by the pi of the rHSA, the pi of the mAb and the nature of the columns used, it was possible to propose a set of general conditions that allows quantification of the aggregation level of a therapeutic protein in the presence of a proteinaceous excipient: The excipient protein and protein of interest should differ in pi by a minimum of 0.5 units, and the pi of the protein of interest should not be higher than ca. 8.5." @default.
• W2029121484 created "2016-06-24" @default.
• W2029121484 creator A5036992593 @default.
• W2029121484 creator A5052768105 @default.
• W2029121484 creator A5058582580 @default.
• W2029121484 creator A5062803042 @default.
• W2029121484 date "2015-02-01" @default.
• W2029121484 modified "2023-10-12" @default.
• W2029121484 title "Serial Coupling of Ion-Exchange and Size-Exclusion Chromatography to Determine Aggregation Levels in mAbs in The Presence of a Proteinaceous Excipient, Recombinant Human Serum Albumin" @default.
• W2029121484 cites W1505290993 @default.
• W2029121484 cites W1966693841 @default.
• W2029121484 cites W1973555453 @default.
• W2029121484 cites W1977357831 @default.
• W2029121484 cites W1983451990 @default.
• W2029121484 cites W1985941856 @default.
• W2029121484 cites W1991863791 @default.
• W2029121484 cites W1991927324 @default.
• W2029121484 cites W1996818420 @default.
• W2029121484 cites W2008349406 @default.
• W2029121484 cites W2023807542 @default.
• W2029121484 cites W2042601819 @default.
• W2029121484 cites W2061308122 @default.
• W2029121484 cites W2064965107 @default.
• W2029121484 cites W2071095038 @default.
• W2029121484 cites W2075418079 @default.
• W2029121484 cites W2096359889 @default.
• W2029121484 cites W2102665585 @default.
• W2029121484 cites W2107295555 @default.
• W2029121484 cites W2111877521 @default.
• W2029121484 cites W2121517303 @default.
• W2029121484 cites W2151543787 @default.
• W2029121484 cites W2333261144 @default.
• W2029121484 doi "https://doi.org/10.1002/jps.24275" @default.
• W2029121484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25447946" @default.
• W2029121484 hasPublicationYear "2015" @default.
• W2029121484 type Work @default.
• W2029121484 sameAs 2029121484 @default.
• W2029121484 citedByCount "5" @default.
• W2029121484 countsByYear W20291214842017 @default.
• W2029121484 countsByYear W20291214842018 @default.
• W2029121484 countsByYear W20291214842019 @default.
• W2029121484 countsByYear W20291214842020 @default.
• W2029121484 countsByYear W20291214842023 @default.
• W2029121484 crossrefType "journal-article" @default.
• W2029121484 hasAuthorship W2029121484A5036992593 @default.
• W2029121484 hasAuthorship W2029121484A5052768105 @default.
• W2029121484 hasAuthorship W2029121484A5058582580 @default.
• W2029121484 hasAuthorship W2029121484A5062803042 @default.
• W2029121484 hasConcept C104317684 @default.
• W2029121484 hasConcept C117760992 @default.
• W2029121484 hasConcept C136238340 @default.
• W2029121484 hasConcept C145148216 @default.
• W2029121484 hasConcept C159654299 @default.
• W2029121484 hasConcept C178790620 @default.
• W2029121484 hasConcept C181199279 @default.
• W2029121484 hasConcept C185592680 @default.
• W2029121484 hasConcept C18743360 @default.
• W2029121484 hasConcept C193363816 @default.
• W2029121484 hasConcept C203014093 @default.
• W2029121484 hasConcept C2776125364 @default.
• W2029121484 hasConcept C2777239854 @default.
• W2029121484 hasConcept C40767141 @default.
• W2029121484 hasConcept C41625074 @default.
• W2029121484 hasConcept C43617362 @default.
• W2029121484 hasConcept C48314217 @default.
• W2029121484 hasConcept C542903549 @default.
• W2029121484 hasConcept C55493867 @default.
• W2029121484 hasConcept C73826308 @default.
• W2029121484 hasConcept C86803240 @default.
• W2029121484 hasConceptScore W2029121484C104317684 @default.
• W2029121484 hasConceptScore W2029121484C117760992 @default.
• W2029121484 hasConceptScore W2029121484C136238340 @default.
• W2029121484 hasConceptScore W2029121484C145148216 @default.
• W2029121484 hasConceptScore W2029121484C159654299 @default.
• W2029121484 hasConceptScore W2029121484C178790620 @default.
• W2029121484 hasConceptScore W2029121484C181199279 @default.
• W2029121484 hasConceptScore W2029121484C185592680 @default.
• W2029121484 hasConceptScore W2029121484C18743360 @default.
• W2029121484 hasConceptScore W2029121484C193363816 @default.
• W2029121484 hasConceptScore W2029121484C203014093 @default.
• W2029121484 hasConceptScore W2029121484C2776125364 @default.
• W2029121484 hasConceptScore W2029121484C2777239854 @default.
• W2029121484 hasConceptScore W2029121484C40767141 @default.
• W2029121484 hasConceptScore W2029121484C41625074 @default.
• W2029121484 hasConceptScore W2029121484C43617362 @default.
• W2029121484 hasConceptScore W2029121484C48314217 @default.
• W2029121484 hasConceptScore W2029121484C542903549 @default.
• W2029121484 hasConceptScore W2029121484C55493867 @default.
• W2029121484 hasConceptScore W2029121484C73826308 @default.
• W2029121484 hasConceptScore W2029121484C86803240 @default.
• W2029121484 hasIssue "2" @default.
• W2029121484 hasLocation W20291214841 @default.
• W2029121484 hasLocation W20291214842 @default.
• W2029121484 hasOpenAccess W2029121484 @default.
• W2029121484 hasPrimaryLocation W20291214841 @default.
• W2029121484 hasRelatedWork W1998547870 @default.
• W2029121484 hasRelatedWork W2005165146 @default.
• W2029121484 hasRelatedWork W2027372351 @default.

• next