FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029122003> ?p ?o ?g. }

• W2029122003 endingPage "5468" @default.
• W2029122003 startingPage "5463" @default.
• W2029122003 abstract "Among the goals of RNA structural and functional genomics is determining structures and establishing the functions of a rich repertoire of simple sequence repeats in transcripts. These repeats are present in transcripts from their ‘birth’ in the nucleus to their ‘death’ in cytoplasm and have the potential of being involved in many steps of RNA regulation. The knowledge of their structural features and functional roles will also shed more light on the postulated mechanisms of RNA pathogenesis in a growing list of neurological diseases caused by simple sequence repeat expansions. Here, we discuss several different lines of research to support the hypothesis that the mechanism of RNA pathogenesis may be a more common phenomenon triggered or modulated also by abundant long normal repeats. We propose structures of the repeat regions in transcripts of genes involved in Triplet Repeat Expansion Diseases. We have classified the polymorphic repeat alleles of these genes according to their ability to form hairpin structures in transcripts, and describe the distribution of different structural forms of the repeats in the human population. We have also reported the results of a systematic survey of the human transcriptome to identify mRNAs containing triplet repeats and to classify them according to structural and functional criteria. Based on this knowledge, we discuss the putative wider role of triplet repeat RNA hairpins in human diseases. A hypothetical model is proposed in which long normal RNA hairpins formed by the repeats may also be involved in pathogenesis." @default.
• W2029122003 created "2016-06-24" @default.
• W2029122003 creator A5087813219 @default.
• W2029122003 date "2003-10-01" @default.
• W2029122003 modified "2023-09-23" @default.
• W2029122003 title "Structures of trinucleotide repeats in human transcripts and their functional implications" @default.
• W2029122003 cites W1506201015 @default.
• W2029122003 cites W1538689496 @default.
• W2029122003 cites W1544519062 @default.
• W2029122003 cites W1555409852 @default.
• W2029122003 cites W1556016736 @default.
• W2029122003 cites W1556711437 @default.
• W2029122003 cites W1972970552 @default.
• W2029122003 cites W1977510643 @default.
• W2029122003 cites W1986071629 @default.
• W2029122003 cites W1986461863 @default.
• W2029122003 cites W1986804263 @default.
• W2029122003 cites W1988498459 @default.
• W2029122003 cites W1989429141 @default.
• W2029122003 cites W1991206252 @default.
• W2029122003 cites W1994674028 @default.
• W2029122003 cites W1995713221 @default.
• W2029122003 cites W1999617545 @default.
• W2029122003 cites W2002780348 @default.
• W2029122003 cites W2009818318 @default.
• W2029122003 cites W2010078405 @default.
• W2029122003 cites W2020334159 @default.
• W2029122003 cites W2039214189 @default.
• W2029122003 cites W2039440352 @default.
• W2029122003 cites W2043156173 @default.
• W2029122003 cites W2045131720 @default.
• W2029122003 cites W2058426472 @default.
• W2029122003 cites W2060286924 @default.
• W2029122003 cites W2064654376 @default.
• W2029122003 cites W2065816205 @default.
• W2029122003 cites W2070224195 @default.
• W2029122003 cites W2072384504 @default.
• W2029122003 cites W2073156864 @default.
• W2029122003 cites W2075338220 @default.
• W2029122003 cites W2076732045 @default.
• W2029122003 cites W2078217107 @default.
• W2029122003 cites W2081280332 @default.
• W2029122003 cites W2088680533 @default.
• W2029122003 cites W2089191243 @default.
• W2029122003 cites W2099673459 @default.
• W2029122003 cites W2099739859 @default.
• W2029122003 cites W2100275934 @default.
• W2029122003 cites W2111147396 @default.
• W2029122003 cites W2112194054 @default.
• W2029122003 cites W2113918626 @default.
• W2029122003 cites W2118428181 @default.
• W2029122003 cites W2122776931 @default.
• W2029122003 cites W2127118078 @default.
• W2029122003 cites W2140188816 @default.
• W2029122003 cites W2141124826 @default.
• W2029122003 cites W2142710492 @default.
• W2029122003 cites W2144969895 @default.
• W2029122003 cites W2147693262 @default.
• W2029122003 cites W2158155007 @default.
• W2029122003 cites W2159599680 @default.
• W2029122003 cites W2167616277 @default.
• W2029122003 cites W2168909179 @default.
• W2029122003 cites W2171605197 @default.
• W2029122003 cites W2171805190 @default.
• W2029122003 cites W386603110 @default.
• W2029122003 cites W4244779656 @default.
• W2029122003 cites W4253161526 @default.
• W2029122003 doi "https://doi.org/10.1093/nar/gkg767" @default.
• W2029122003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/206467" @default.
• W2029122003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14500808" @default.
• W2029122003 hasPublicationYear "2003" @default.
• W2029122003 type Work @default.
• W2029122003 sameAs 2029122003 @default.
• W2029122003 citedByCount "74" @default.
• W2029122003 countsByYear W20291220032012 @default.
• W2029122003 countsByYear W20291220032013 @default.
• W2029122003 countsByYear W20291220032014 @default.
• W2029122003 countsByYear W20291220032015 @default.
• W2029122003 countsByYear W20291220032016 @default.
• W2029122003 countsByYear W20291220032017 @default.
• W2029122003 countsByYear W20291220032018 @default.
• W2029122003 countsByYear W20291220032019 @default.
• W2029122003 countsByYear W20291220032021 @default.
• W2029122003 countsByYear W20291220032022 @default.
• W2029122003 countsByYear W20291220032023 @default.
• W2029122003 crossrefType "journal-article" @default.
• W2029122003 hasAuthorship W2029122003A5087813219 @default.
• W2029122003 hasBestOaLocation W20291220031 @default.
• W2029122003 hasConcept C104317684 @default.
• W2029122003 hasConcept C141231307 @default.
• W2029122003 hasConcept C150194340 @default.
• W2029122003 hasConcept C162317418 @default.
• W2029122003 hasConcept C166252455 @default.
• W2029122003 hasConcept C180754005 @default.
• W2029122003 hasConcept C29511175 @default.
• W2029122003 hasConcept C41282012 @default.
• W2029122003 hasConcept C54355233 @default.
• W2029122003 hasConcept C67705224 @default.

• next