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- W2029122074 abstract "We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-yl)-3-(dimethylamino)propanamide (1) as an effective neuroprotectant and selective butyrylcholinesterase inhibitor. In this paper, we have developed a series of N-acylaminophenothiazines obtained from our compound library or newly synthesised. At micro- and sub-micromolar concentrations, these compounds selectively inhibited butyrylcholinesterase (BuChE), protected neurons against damage caused by both exogenous and mitochondrial free radicals, showed low toxicity, and could penetrate into the CNS. In addition, N-(3-chloro-10H-phenothiazin-10-yl)-2-(pyrrolidin-1-yl)acetamide (11) modulated the cytosolic calcium concentration and protected human neuroblastoma cells against several toxics, such as calcium overload induced by an l-type Ca2+-channel agonist, tau-hyperphosphorylation induced by okadaic acid and Aβ peptide." @default.
- W2029122074 created "2016-06-24" @default.
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- W2029122074 date "2011-06-01" @default.
- W2029122074 modified "2023-10-18" @default.
- W2029122074 title "N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer’s disease" @default.
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- W2029122074 doi "https://doi.org/10.1016/j.ejmech.2011.03.003" @default.
- W2029122074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21420206" @default.
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