Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029122705> ?p ?o ?g. }
- W2029122705 endingPage "1195" @default.
- W2029122705 startingPage "1181" @default.
- W2029122705 abstract "Cytokinesis is crucial for integrating genome inheritance and cell functions. In multicellular organisms, Rho-guanine nucleotide exchange factors (GEFs) and Rho GTPases are key regulators of division-plane specification and contractile-ring formation during cytokinesis, but how they regulate early steps of cytokinesis in fission yeast remains largely unknown. Here we show that putative Rho-GEF Gef2 and Polo kinase Plo1 coordinate to control the medial cortical localization and function of anillin-related protein Mid1. The division-site positioning defects of gef2∆ plo1-ts18 double mutant can be partially rescued by increasing Mid1 levels. We find that Gef2 physically interacts with the Mid1 N-terminus and modulates Mid1 cortical binding. Gef2 localization to cortical nodes and the contractile ring depends on its last 145 residues, and the DBL-homology domain is important for its function in cytokinesis. Our data suggest the interaction between Rho-GEFs and anillins is an important step in the signaling pathways during cytokinesis. In addition, Gef2 also regulates contractile-ring function late in cytokinesis and may negatively regulate the septation initiation network. Collectively, we propose that Gef2 facilitates and stabilizes Mid1 binding to the medial cortex, where the localized Mid1 specifies the division site and induces contractile-ring assembly." @default.
- W2029122705 created "2016-06-24" @default.
- W2029122705 creator A5011723131 @default.
- W2029122705 creator A5027601906 @default.
- W2029122705 creator A5062923032 @default.
- W2029122705 creator A5066026692 @default.
- W2029122705 date "2012-04-01" @default.
- W2029122705 modified "2023-09-28" @default.
- W2029122705 title "Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis" @default.
- W2029122705 cites W1588070059 @default.
- W2029122705 cites W1946787175 @default.
- W2029122705 cites W1964617500 @default.
- W2029122705 cites W1966535614 @default.
- W2029122705 cites W1966855723 @default.
- W2029122705 cites W1969978677 @default.
- W2029122705 cites W1970442105 @default.
- W2029122705 cites W1974297828 @default.
- W2029122705 cites W1974325386 @default.
- W2029122705 cites W1979448608 @default.
- W2029122705 cites W1979708251 @default.
- W2029122705 cites W1983703794 @default.
- W2029122705 cites W1984772555 @default.
- W2029122705 cites W1984980345 @default.
- W2029122705 cites W1990265320 @default.
- W2029122705 cites W1992975217 @default.
- W2029122705 cites W1993104438 @default.
- W2029122705 cites W1994644540 @default.
- W2029122705 cites W1998143618 @default.
- W2029122705 cites W2000055300 @default.
- W2029122705 cites W2002964349 @default.
- W2029122705 cites W2011835154 @default.
- W2029122705 cites W2012842165 @default.
- W2029122705 cites W2013676093 @default.
- W2029122705 cites W2014276510 @default.
- W2029122705 cites W2015553818 @default.
- W2029122705 cites W2018680653 @default.
- W2029122705 cites W2021218555 @default.
- W2029122705 cites W2030086669 @default.
- W2029122705 cites W2030184227 @default.
- W2029122705 cites W2035012684 @default.
- W2029122705 cites W2036263649 @default.
- W2029122705 cites W2038431416 @default.
- W2029122705 cites W2039177181 @default.
- W2029122705 cites W2040541572 @default.
- W2029122705 cites W2040825881 @default.
- W2029122705 cites W2042464607 @default.
- W2029122705 cites W2043147257 @default.
- W2029122705 cites W2044341058 @default.
- W2029122705 cites W2049863303 @default.
- W2029122705 cites W2053590666 @default.
- W2029122705 cites W2056889742 @default.
- W2029122705 cites W2056967573 @default.
- W2029122705 cites W2059202305 @default.
- W2029122705 cites W2066398198 @default.
- W2029122705 cites W2066618807 @default.
- W2029122705 cites W2066883617 @default.
- W2029122705 cites W2067159411 @default.
- W2029122705 cites W2067508665 @default.
- W2029122705 cites W2068798734 @default.
- W2029122705 cites W2070326039 @default.
- W2029122705 cites W2075331295 @default.
- W2029122705 cites W2078631770 @default.
- W2029122705 cites W2079835640 @default.
- W2029122705 cites W2083523423 @default.
- W2029122705 cites W2083886506 @default.
- W2029122705 cites W2085308794 @default.
- W2029122705 cites W2088266134 @default.
- W2029122705 cites W2091060631 @default.
- W2029122705 cites W2094269474 @default.
- W2029122705 cites W2095649347 @default.
- W2029122705 cites W2096450743 @default.
- W2029122705 cites W2096791952 @default.
- W2029122705 cites W2098093019 @default.
- W2029122705 cites W2103228775 @default.
- W2029122705 cites W2103813564 @default.
- W2029122705 cites W2106008443 @default.
- W2029122705 cites W2107294909 @default.
- W2029122705 cites W2107854919 @default.
- W2029122705 cites W2108176026 @default.
- W2029122705 cites W2108204774 @default.
- W2029122705 cites W2108641962 @default.
- W2029122705 cites W2108678775 @default.
- W2029122705 cites W2114580275 @default.
- W2029122705 cites W2118272396 @default.
- W2029122705 cites W2121944671 @default.
- W2029122705 cites W2123789526 @default.
- W2029122705 cites W2123924160 @default.
- W2029122705 cites W2127303707 @default.
- W2029122705 cites W2129900178 @default.
- W2029122705 cites W2131429362 @default.
- W2029122705 cites W2133638641 @default.
- W2029122705 cites W2134580403 @default.
- W2029122705 cites W2135595304 @default.
- W2029122705 cites W2140858258 @default.
- W2029122705 cites W2146663079 @default.
- W2029122705 cites W2149909679 @default.
- W2029122705 cites W2152288059 @default.
- W2029122705 cites W2153419157 @default.