FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029122990> ?p ?o ?g. }

• W2029122990 endingPage "297" @default.
• W2029122990 startingPage "292" @default.
• W2029122990 abstract "Abstract: Ultraviolet B (UV-B) irradiation of donor islets has previously been shown to result in the prolongation of their survival when transplanted into rodents. This study examined the in vitro and in vivo effects of UV-B irradiation on fetal pig islet-like cell clusters (ICCs), which like adult islets are being transplanted to reverse diabetes. Under control conditions, fetal pig ICCs were able to stimulate both human and pig peripheral blood mononuclear cells (PBMC) in mixed islet lymphocyte culture (MILC). Exposure of the ICCs to UV-B irradiation significantly reduced their ability to stimulate PBMC of both species in MILC when 600 J/m2 but not lower doses (300 and 400 J/m2) of irradiation were applied. In contrast, all doses of UV-B irradiation were effective in inhibiting the ability of pig and human PBMC to stimulate human PBMC in a mixed lymphocytes culture (MLC). This demonstrates that UV-B irradiation is effective in reducing xeno immunogenicity of pig antigens. A toxic effect of all doses of UV-B irradiation on ICCs was demonstrated in vitro with a reduction in 3H-thymidine incorporation of 57, 71, 64, and 80% at 150, 300, 450, and 600 J/m2, respectively. Toxicity of UV-B irradiation was also demonstrated when treated ICCs were transplanted beneath the renal capsule of SCID mice. The insulin content of the ICCs, 6 weeks after transplantation, was significantly reduced in the 600 J/m2 group (P<0.05). ICCs treated with UV-B irradiation (300 J/m2) in vitro and then transplanted beneath the renal capsule of BALB/c mice were rejected within 2 weeks as were untreated ICCs. Injection of cyclosporine (12.5 mg/kg/day) into these mice did not alter the results. It is concluded that UV-B irradiation is toxic to fetal pig ICCs and, in low dose, unable to prevent their rejection when transplanted into mice." @default.
• W2029122990 created "2016-06-24" @default.
• W2029122990 creator A5014762176 @default.
• W2029122990 creator A5073453806 @default.
• W2029122990 date "1998-11-01" @default.
• W2029122990 modified "2023-09-27" @default.
• W2029122990 title "Effects of ultraviolet B irradiation on fetal pig islet-like cell clusters" @default.
• W2029122990 cites W14705976 @default.
• W2029122990 cites W1963568183 @default.
• W2029122990 cites W1973604341 @default.
• W2029122990 cites W1981195976 @default.
• W2029122990 cites W1984988673 @default.
• W2029122990 cites W1992451844 @default.
• W2029122990 cites W1996084193 @default.
• W2029122990 cites W2004160331 @default.
• W2029122990 cites W2024711583 @default.
• W2029122990 cites W2024838665 @default.
• W2029122990 cites W2034848311 @default.
• W2029122990 cites W2045134465 @default.
• W2029122990 cites W2053081561 @default.
• W2029122990 cites W2076426660 @default.
• W2029122990 cites W2085637800 @default.
• W2029122990 cites W2086366727 @default.
• W2029122990 cites W2086871005 @default.
• W2029122990 cites W2092185107 @default.
• W2029122990 cites W2102221374 @default.
• W2029122990 cites W4231008311 @default.
• W2029122990 cites W4236272660 @default.
• W2029122990 cites W1968496016 @default.
• W2029122990 doi "https://doi.org/10.1111/j.1399-3089.1998.tb00040.x" @default.
• W2029122990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9915257" @default.
• W2029122990 hasPublicationYear "1998" @default.
• W2029122990 type Work @default.
• W2029122990 sameAs 2029122990 @default.
• W2029122990 citedByCount "5" @default.
• W2029122990 countsByYear W20291229902014 @default.
• W2029122990 countsByYear W20291229902018 @default.
• W2029122990 countsByYear W20291229902019 @default.
• W2029122990 crossrefType "journal-article" @default.
• W2029122990 hasAuthorship W2029122990A5014762176 @default.
• W2029122990 hasAuthorship W2029122990A5073453806 @default.
• W2029122990 hasConcept C111337013 @default.
• W2029122990 hasConcept C121332964 @default.
• W2029122990 hasConcept C126322002 @default.
• W2029122990 hasConcept C134018914 @default.
• W2029122990 hasConcept C137061746 @default.
• W2029122990 hasConcept C150903083 @default.
• W2029122990 hasConcept C153911025 @default.
• W2029122990 hasConcept C165220095 @default.
• W2029122990 hasConcept C16685009 @default.
• W2029122990 hasConcept C172680121 @default.
• W2029122990 hasConcept C185544564 @default.
• W2029122990 hasConcept C185592680 @default.
• W2029122990 hasConcept C202751555 @default.
• W2029122990 hasConcept C203014093 @default.
• W2029122990 hasConcept C207001950 @default.
• W2029122990 hasConcept C2778442404 @default.
• W2029122990 hasConcept C2779234561 @default.
• W2029122990 hasConcept C2779306644 @default.
• W2029122990 hasConcept C2911091166 @default.
• W2029122990 hasConcept C54355233 @default.
• W2029122990 hasConcept C55493867 @default.
• W2029122990 hasConcept C71924100 @default.
• W2029122990 hasConcept C86803240 @default.
• W2029122990 hasConceptScore W2029122990C111337013 @default.
• W2029122990 hasConceptScore W2029122990C121332964 @default.
• W2029122990 hasConceptScore W2029122990C126322002 @default.
• W2029122990 hasConceptScore W2029122990C134018914 @default.
• W2029122990 hasConceptScore W2029122990C137061746 @default.
• W2029122990 hasConceptScore W2029122990C150903083 @default.
• W2029122990 hasConceptScore W2029122990C153911025 @default.
• W2029122990 hasConceptScore W2029122990C165220095 @default.
• W2029122990 hasConceptScore W2029122990C16685009 @default.
• W2029122990 hasConceptScore W2029122990C172680121 @default.
• W2029122990 hasConceptScore W2029122990C185544564 @default.
• W2029122990 hasConceptScore W2029122990C185592680 @default.
• W2029122990 hasConceptScore W2029122990C202751555 @default.
• W2029122990 hasConceptScore W2029122990C203014093 @default.
• W2029122990 hasConceptScore W2029122990C207001950 @default.
• W2029122990 hasConceptScore W2029122990C2778442404 @default.
• W2029122990 hasConceptScore W2029122990C2779234561 @default.
• W2029122990 hasConceptScore W2029122990C2779306644 @default.
• W2029122990 hasConceptScore W2029122990C2911091166 @default.
• W2029122990 hasConceptScore W2029122990C54355233 @default.
• W2029122990 hasConceptScore W2029122990C55493867 @default.
• W2029122990 hasConceptScore W2029122990C71924100 @default.
• W2029122990 hasConceptScore W2029122990C86803240 @default.
• W2029122990 hasIssue "4" @default.
• W2029122990 hasLocation W20291229901 @default.
• W2029122990 hasLocation W20291229902 @default.
• W2029122990 hasOpenAccess W2029122990 @default.
• W2029122990 hasPrimaryLocation W20291229901 @default.
• W2029122990 hasRelatedWork W2034418400 @default.
• W2029122990 hasRelatedWork W2125998432 @default.
• W2029122990 hasRelatedWork W2138758116 @default.
• W2029122990 hasRelatedWork W2170386768 @default.
• W2029122990 hasRelatedWork W2210249867 @default.
• W2029122990 hasRelatedWork W2318378958 @default.

• next