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- W2029124536 endingPage "702" @default.
- W2029124536 startingPage "689" @default.
- W2029124536 abstract "Phosphodiesterase 5 inhibitors augment endogenous nitric oxide signalling, thereby restoring vascular reactivity to diseased blood vessels. Ghofrani and colleagues review the evolution of the PDE5 inhibitor sildenafil from a potential anti-angina drug, to an on-demand oral treatment for erectile dysfunction, and its recent re-positioning as a pulmonary hypertension therapeutic. In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has evolved from a potential anti-angina drug to an on-demand oral treatment for erectile dysfunction (Viagra), and more recently to a new orally active treatment for pulmonary hypertension (Revatio). Here we describe the key milestones in the development of sildenafil for these diverse medical conditions, discuss the advances in science and clinical medicine that have accompanied this journey and consider possible future indications for this versatile drug." @default.
- W2029124536 created "2016-06-24" @default.
- W2029124536 creator A5056471991 @default.
- W2029124536 creator A5083839456 @default.
- W2029124536 creator A5084935661 @default.
- W2029124536 date "2006-08-01" @default.
- W2029124536 modified "2023-10-16" @default.
- W2029124536 title "Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond" @default.
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