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• W2029124946 startingPage "2179" @default.
• W2029124946 abstract "To estimate the impact of small changes in plasma levels of HIV-1 RNA on the risk of heterosexual transmission or disease progression to an AIDS-defining event or death.We systematically reviewed the published literature for studies that evaluated small viral load changes among antiretroviral-therapy-naive, adult populations. We modeled relative risk estimates for viral transmission and disease progression according to 0.3, 0.5, and 1.0 log10 increments of HIV load.We calculated that the likelihood of transmitting HIV by heterosexual contact increased, on average, by 20% and that the annual risk of progression to an AIDS-defining illness or related death increased by 25% with every 0.3 log10 increment in HIV RNA. A 0.5 log10 increment in HIV RNA was associated with 40% greater risk of heterosexual transmission and 44% increased risk of progression to AIDS or death. A 1.0 log10 increment in HIV RNA was associated with 100% greater risk of heterosexual transmission and 113% increased risk of progression to AIDS or death.Antiretroviral therapy continues to be unavailable or not-yet-indicated for 72% of the world's HIV-infected persons. Mounting evidence that treatment of coinfections may reduce HIV viral load, even modestly, suggests the priority of improved adjunctive care for HIV-infected persons even without antiretroviral therapy, both to slow disease progression and to reduce infectiousness." @default.
• W2029124946 created "2016-06-24" @default.
• W2029124946 creator A5005806545 @default.
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• W2029124946 date "2008-10-18" @default.
• W2029124946 modified "2023-10-16" @default.
• W2029124946 title "Impact of small reductions in plasma HIV RNA levels on the risk of heterosexual transmission and disease progression" @default.
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• W2029124946 doi "https://doi.org/10.1097/qad.0b013e328312c756" @default.
• W2029124946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2661869" @default.
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