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- W2029127632 endingPage "780" @default.
- W2029127632 startingPage "769" @default.
- W2029127632 abstract "Sterols such as cholesterol are a significant component of eukaryotic cellular membranes, and their unique physical properties influence a wide variety of membrane processes. It is known that the concentration of sterol within the membrane varies widely between organelles, and that the cell actively maintains this distribution through various transport processes. Vesicular pathways such as secretion or endocytosis may account for this traffic, but increasing evidence highlights the importance of nonvesicular routes as well. The structure of an oxysterol-binding protein homologue (OSH) in yeast (Osh4p/Kes1p) has recently been solved, identifying it as a sterol binding protein, and there is evidence consistent with the role of a cytoplasmic, nonvesicular sterol transporter. Yeast have seven such proteins, which appear to have distinct but overlapping functions with regard to maintaining intracellular sterol distribution and homeostasis. Control of sterol distribution can have far-reaching effects on membrane-related functions, and Osh proteins have been implicated in a variety of processes such as secretory vesicle budding from the Golgi and establishment of cell polarity. This review summarizes the current body of knowledge regarding this family and its potential functions, placing it in the context of known and hypothesized pathways of sterol transport in yeast." @default.
- W2029127632 created "2016-06-24" @default.
- W2029127632 creator A5039218520 @default.
- W2029127632 creator A5058989647 @default.
- W2029127632 date "2007-06-01" @default.
- W2029127632 modified "2023-09-30" @default.
- W2029127632 title "Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family" @default.
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