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• W2029128001 abstract "Aldosterone responsiveness to angiotensin II (A II) was evaluated in 65 diabetic patients with and without various diabetic complications versus 38 age-matched nondiabetic subjects. Plasma aldosterone (PA), together with plasma renin activity (PRA), was low and responded poorly to furosemide (80 mg, orally) plus upright posture (4 hours) stimulation in diabetic patients. When the PA response to stimulation relative to PRA response was estimated from the ratio of PA increase to PRA increase after stimulation (δPA/δPRA), the 38 non-diabetic subjects had ratios more than 3.0. Of the 65 diabetic patients, 48 had normal (δPA/δPRA) ratios (more than 3.0) and 17 had low (δPA/δPRA) ratios (less than 2.9). Graded A II infusions (1, 2, and 4 ng/kg/min each for 30 min) were performed under a low sodium intake (sodium, 120 mEq/day) in 25 of the 65 diabetic patients, whose (δPA/δPRA) ratios were normal in 15 and low in 10, and in 16 non-diabetic subjects. The PA responses to the graded A II infusions in the normal (δPA/δPRA) diabetic patients were similar to those in the non-diabetic subjects. However, the PA responses to the graded A II infusions in the low (δPA/δPRA) diabetic patients were significantly lower.It is concluded that, although the majority of diabetic patients have normal aldosterone responsiveness to A II, some diabetic patients have blunted aldosterone responsiveness to A II probably attributable to the abnormality of the adrenal cortex in addition to the impaired renin secretion." @default.
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• W2029128001 title "Responsiveness of plasma aldosterone to angiotensin II in patients with diabetes mellitus." @default.
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• W2029128001 doi "https://doi.org/10.1507/endocrj1954.30.671" @default.
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