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- W2029132339 abstract "Exponentially growing Meth-A cells expressing H-2Kd·D d antigen were found to induce alopecia when injected intraperitoneally into normal C57BL/6 mice, which express the H-2Kb·D b antigen. However, the capacity to induce alopecia disappeared when Meth-A cells were treated with K252a, which inhibits protein kinases. Histologically, skin in affected areas showed dense mononuclear cell infiltration and a focal foreign-body giant-cell reaction in hair follicles. The subtyping of lymphocytes in peripheral blood demonstrated a significant difference between normal mice and Meth-A cell-injected mice. To further examine the mechanism by which the alloantigen induces alopecia, lymphocytes isolated from the peripheral blood of normal C57BL/6 mice were cultured in medium containing Meth-A cell homogenate, phytohemagglutinin (PHA) and recombinant mouse interleukin-2 (rm IL-2), and intravenously injected into normal C57BL/6 mice. The adoptive transfer of the lymphocytes induced alopecia in a similar way. These findings suggest that the protein kinase-modulated alloantigen induces alopecia by disturbing the immunological homeostasis, and that lymphokine-activated killer cells play an important role in induction of alopecia by cross-reacting with hair follicles." @default.
- W2029132339 created "2016-06-24" @default.
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- W2029132339 date "2003-01-01" @default.
- W2029132339 modified "2023-09-27" @default.
- W2029132339 title "Autoimmune Hair Loss Induced by Alloantigen in C57BL/6 Mice." @default.
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- W2029132339 doi "https://doi.org/10.1247/csf.28.97" @default.
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