FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029133093> ?p ?o ?g. }

• W2029133093 abstract "1. Relaxation of airway smooth muscle induced by vasoactive intestinal peptide (VIP) is mediated by adenosine 3':5' cyclic monophosphate (cyclic AMP). An interaction between the synthesis of cyclic AMP and enzymic activity of the plasmalemmal sodium pump (Na(+)-K(+)-ATPase) exists in certain isolated cell systems. This study sought to determine the contribution of Na(+)-K(+)-ATPase activity to relaxation of airway smooth muscle evoked by VIP. 2. All experiments were performed on isolated strips of guinea-pig trachea from which the epithelium had been removed. VIP was a more potent relaxant in tissues that were contracted with carbachol than those contracted with an equi-effective depolarizing concentration of K+. 3. Ouabain (0.1 microM-10 microM) induced contraction of tracheal strips. Contraction to ouabain (5 microM) was abolished following incubation of tissues with K(+)-free, or Ca(2+)-free (+ EGTA, 0.1 mM) physiological solutions. The contractile response to ouabain (5 microM) was not influenced significantly by exposure of the tissues to atropine (1 microM), phentolamine (5 microM) and diphenhydramine (1 microM) for 60 min. 4. Tissues were incubated with ouabain (5 microM; 60 min) or K(+)-free physiological solution (60 min) to inhibit Na(+)-K(+)-ATPase activity. These procedures reduced relaxation induced by VIP, peptide histidine isoleucine, forskolin, isoprenaline and sodium nitroprusside. 5. Relaxation to VIP was impaired significantly following exposure of tissues to a low Na+ solution (30 min) or amiloride (500 microM; 30 min). 6. Ouabain-sensitive uptake of 86Rb was measured in tracheal strips (devoid of epithelium and cartilage) as an index of Na(+)-K(+)-ATPase activity. VIP (1 microM; 2 min) caused a 4.7 fold stimulation of ouabain-sensitive uptake of 86Rb. This effect was impaired significantly by low Na+ solution. 7. The results suggest that (i) relaxation of tracheal smooth muscle to VIP is sensitive to procedures that inhibit activity of Na(+)-K(+)-ATPase and invoke a role for altered sodium pump function in the mechanisms that underlie cyclic AMP-dependent relaxation; and (ii) VIP stimulates ouabain-sensitive uptake of 86Rb in airway smooth muscle in a Na(+)-dependent manner." @default.
• W2029133093 created "2016-06-24" @default.
• W2029133093 creator A5017583914 @default.
• W2029133093 creator A5018541150 @default.
• W2029133093 date "1996-06-01" @default.
• W2029133093 modified "2023-09-24" @default.
• W2029133093 title "Stimulation of sodium pump by vasoactive intestinal peptide in guinea-pig isolated trachea: potential contribution to mechanisms underlying relaxation of smooth muscle" @default.
• W2029133093 cites W1481860092 @default.
• W2029133093 cites W1585362347 @default.
• W2029133093 cites W1842940248 @default.
• W2029133093 cites W1976804955 @default.
• W2029133093 cites W1980516585 @default.
• W2029133093 cites W1983733445 @default.
• W2029133093 cites W2006267865 @default.
• W2029133093 cites W2010215031 @default.
• W2029133093 cites W2010594725 @default.
• W2029133093 cites W2044435391 @default.
• W2029133093 cites W2051231769 @default.
• W2029133093 cites W2065203161 @default.
• W2029133093 cites W2074353240 @default.
• W2029133093 cites W2079717243 @default.
• W2029133093 cites W2094779294 @default.
• W2029133093 cites W2095300169 @default.
• W2029133093 cites W2119350257 @default.
• W2029133093 cites W2170081031 @default.
• W2029133093 cites W2207973928 @default.
• W2029133093 cites W2269145079 @default.
• W2029133093 cites W2334080377 @default.
• W2029133093 cites W2396186684 @default.
• W2029133093 cites W2402975138 @default.
• W2029133093 cites W2407488765 @default.
• W2029133093 cites W2413171618 @default.
• W2029133093 cites W2417576989 @default.
• W2029133093 doi "https://doi.org/10.1111/j.1476-5381.1996.tb15438.x" @default.
• W2029133093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1909717" @default.
• W2029133093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8762078" @default.
• W2029133093 hasPublicationYear "1996" @default.
• W2029133093 type Work @default.
• W2029133093 sameAs 2029133093 @default.
• W2029133093 citedByCount "8" @default.
• W2029133093 crossrefType "journal-article" @default.
• W2029133093 hasAuthorship W2029133093A5017583914 @default.
• W2029133093 hasAuthorship W2029133093A5018541150 @default.
• W2029133093 hasBestOaLocation W20291330932 @default.
• W2029133093 hasConcept C118303440 @default.
• W2029133093 hasConcept C126322002 @default.
• W2029133093 hasConcept C134018914 @default.
• W2029133093 hasConcept C163415756 @default.
• W2029133093 hasConcept C170493617 @default.
• W2029133093 hasConcept C178790620 @default.
• W2029133093 hasConcept C185592680 @default.
• W2029133093 hasConcept C24998067 @default.
• W2029133093 hasConcept C2776050358 @default.
• W2029133093 hasConcept C2776090920 @default.
• W2029133093 hasConcept C2776991684 @default.
• W2029133093 hasConcept C2779133857 @default.
• W2029133093 hasConcept C2779276759 @default.
• W2029133093 hasConcept C2779610285 @default.
• W2029133093 hasConcept C2992204568 @default.
• W2029133093 hasConcept C519581460 @default.
• W2029133093 hasConcept C537181965 @default.
• W2029133093 hasConcept C55493867 @default.
• W2029133093 hasConcept C71924100 @default.
• W2029133093 hasConcept C8330315 @default.
• W2029133093 hasConcept C86803240 @default.
• W2029133093 hasConceptScore W2029133093C118303440 @default.
• W2029133093 hasConceptScore W2029133093C126322002 @default.
• W2029133093 hasConceptScore W2029133093C134018914 @default.
• W2029133093 hasConceptScore W2029133093C163415756 @default.
• W2029133093 hasConceptScore W2029133093C170493617 @default.
• W2029133093 hasConceptScore W2029133093C178790620 @default.
• W2029133093 hasConceptScore W2029133093C185592680 @default.
• W2029133093 hasConceptScore W2029133093C24998067 @default.
• W2029133093 hasConceptScore W2029133093C2776050358 @default.
• W2029133093 hasConceptScore W2029133093C2776090920 @default.
• W2029133093 hasConceptScore W2029133093C2776991684 @default.
• W2029133093 hasConceptScore W2029133093C2779133857 @default.
• W2029133093 hasConceptScore W2029133093C2779276759 @default.
• W2029133093 hasConceptScore W2029133093C2779610285 @default.
• W2029133093 hasConceptScore W2029133093C2992204568 @default.
• W2029133093 hasConceptScore W2029133093C519581460 @default.
• W2029133093 hasConceptScore W2029133093C537181965 @default.
• W2029133093 hasConceptScore W2029133093C55493867 @default.
• W2029133093 hasConceptScore W2029133093C71924100 @default.
• W2029133093 hasConceptScore W2029133093C8330315 @default.
• W2029133093 hasConceptScore W2029133093C86803240 @default.
• W2029133093 hasLocation W20291330931 @default.
• W2029133093 hasLocation W20291330932 @default.
• W2029133093 hasLocation W20291330933 @default.
• W2029133093 hasLocation W20291330934 @default.
• W2029133093 hasOpenAccess W2029133093 @default.
• W2029133093 hasPrimaryLocation W20291330931 @default.
• W2029133093 hasRelatedWork W1967606258 @default.
• W2029133093 hasRelatedWork W1999261509 @default.
• W2029133093 hasRelatedWork W1999264478 @default.
• W2029133093 hasRelatedWork W2029133093 @default.
• W2029133093 hasRelatedWork W2084924983 @default.
• W2029133093 hasRelatedWork W2085394738 @default.
• W2029133093 hasRelatedWork W2088160386 @default.
• W2029133093 hasRelatedWork W2088427854 @default.

• next