Matches in SemOpenAlex for { <https://semopenalex.org/work/W202913441> ?p ?o ?g. }
- W202913441 abstract "Recent clinical and experimental evidences demonstrate an association between augmented circulating lipocalin-2 [a pro-inflammatory adipokine] and cardiac dysfunction. However, little is known about the pathophysi-ological role of lipocalin-2 in heart. The present study was designed to compare the heart functions of mice with normal (WT) or deficient lipocalin-2 (Lcn2-KO) expression.Echocardiographic analysis revealed that the myocardial contractile function was significantly improved in hearts of Lcn2-KO mice, under both standard chow and high fat diet conditions. The heart function before and after I/R injury (20-min of global ischemia followed by 60-min of reperfusion) was assessed using the Langendorff perfusion system. Compared to WT littermates, hearts from Lcn2-KO mice showed improved functional recovery and reduced infarct size following I/R. Under baseline condition, the mitochondrial function of Lcn2-KO hearts was significantly enhanced, as demonstrated by biochemical analysis of respiratory chain activity and markers of biogenesis, as well as electron microscopic investigation of the mitochondrial ultrastructure. Acute or chronic administration of lipocalin-2 impaired cardiac functional recovery to I/R and dampened the mitochondrial function in hearts of Lcn2-KO mice. These effects were associated with an extensive modification of the fatty acyl chain compositions of intracellular phospholipids. For example, lipocalin-2 facilitated the redistribution of linoleic acid (C18:2) among different types of phospholipids, including cardiolipin, a structurally unique phospholipid located mainly on the inner membrane of mitochondria.Lack of lipocalin-2 improved the functional recovery of isolated mice hearts subjected to I/R, which is associated with restoration of mitochondrial function and phospholipids remodeling." @default.
- W202913441 created "2016-06-24" @default.
- W202913441 creator A5000800493 @default.
- W202913441 creator A5002173310 @default.
- W202913441 creator A5013531203 @default.
- W202913441 creator A5018541150 @default.
- W202913441 creator A5031014820 @default.
- W202913441 creator A5057839636 @default.
- W202913441 creator A5060517378 @default.
- W202913441 creator A5065293277 @default.
- W202913441 creator A5065770366 @default.
- W202913441 creator A5070111620 @default.
- W202913441 creator A5082095539 @default.
- W202913441 creator A5087438839 @default.
- W202913441 date "2012-01-01" @default.
- W202913441 modified "2023-09-27" @default.
- W202913441 title "Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling." @default.
- W202913441 cites W1562553409 @default.
- W202913441 cites W1566575660 @default.
- W202913441 cites W1588950918 @default.
- W202913441 cites W1800061482 @default.
- W202913441 cites W1841050729 @default.
- W202913441 cites W1964257657 @default.
- W202913441 cites W1965419967 @default.
- W202913441 cites W1966120797 @default.
- W202913441 cites W1967542690 @default.
- W202913441 cites W1985787335 @default.
- W202913441 cites W1990588947 @default.
- W202913441 cites W1994873852 @default.
- W202913441 cites W1996699458 @default.
- W202913441 cites W1997763513 @default.
- W202913441 cites W1999024765 @default.
- W202913441 cites W1999791141 @default.
- W202913441 cites W2002359763 @default.
- W202913441 cites W2009303712 @default.
- W202913441 cites W2010466622 @default.
- W202913441 cites W2011726320 @default.
- W202913441 cites W2025144170 @default.
- W202913441 cites W2027813225 @default.
- W202913441 cites W2042183674 @default.
- W202913441 cites W2055237519 @default.
- W202913441 cites W2058151768 @default.
- W202913441 cites W2065104239 @default.
- W202913441 cites W2066458078 @default.
- W202913441 cites W2072087309 @default.
- W202913441 cites W2080197336 @default.
- W202913441 cites W2081893048 @default.
- W202913441 cites W2088782509 @default.
- W202913441 cites W2090330749 @default.
- W202913441 cites W2091398255 @default.
- W202913441 cites W2093093802 @default.
- W202913441 cites W2098494341 @default.
- W202913441 cites W2103950548 @default.
- W202913441 cites W2104816318 @default.
- W202913441 cites W2109128578 @default.
- W202913441 cites W2114991593 @default.
- W202913441 cites W2115801388 @default.
- W202913441 cites W2123416046 @default.
- W202913441 cites W2125189862 @default.
- W202913441 cites W2125857619 @default.
- W202913441 cites W2130062246 @default.
- W202913441 cites W2135091756 @default.
- W202913441 cites W2148658873 @default.
- W202913441 cites W2153500348 @default.
- W202913441 cites W2153819921 @default.
- W202913441 cites W2157105773 @default.
- W202913441 cites W2169392626 @default.
- W202913441 cites W2169682503 @default.
- W202913441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280429" @default.
- W202913441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22355443" @default.
- W202913441 hasPublicationYear "2012" @default.
- W202913441 type Work @default.
- W202913441 sameAs 202913441 @default.
- W202913441 citedByCount "9" @default.
- W202913441 countsByYear W2029134412014 @default.
- W202913441 countsByYear W2029134412015 @default.
- W202913441 countsByYear W2029134412016 @default.
- W202913441 countsByYear W2029134412017 @default.
- W202913441 countsByYear W2029134412018 @default.
- W202913441 countsByYear W2029134412021 @default.
- W202913441 countsByYear W2029134412022 @default.
- W202913441 countsByYear W2029134412023 @default.
- W202913441 crossrefType "journal-article" @default.
- W202913441 hasAuthorship W202913441A5000800493 @default.
- W202913441 hasAuthorship W202913441A5002173310 @default.
- W202913441 hasAuthorship W202913441A5013531203 @default.
- W202913441 hasAuthorship W202913441A5018541150 @default.
- W202913441 hasAuthorship W202913441A5031014820 @default.
- W202913441 hasAuthorship W202913441A5057839636 @default.
- W202913441 hasAuthorship W202913441A5060517378 @default.
- W202913441 hasAuthorship W202913441A5065293277 @default.
- W202913441 hasAuthorship W202913441A5065770366 @default.
- W202913441 hasAuthorship W202913441A5070111620 @default.
- W202913441 hasAuthorship W202913441A5082095539 @default.
- W202913441 hasAuthorship W202913441A5087438839 @default.
- W202913441 hasConcept C111566952 @default.
- W202913441 hasConcept C126322002 @default.
- W202913441 hasConcept C134018914 @default.
- W202913441 hasConcept C14036430 @default.
- W202913441 hasConcept C194832188 @default.