Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029135056> ?p ?o ?g. }
- W2029135056 endingPage "425" @default.
- W2029135056 startingPage "412" @default.
- W2029135056 abstract "Antibodies that neutralize diverse strains of HIV-1 develop in ∼20% of HIV-1-infected individuals, and isolation and structural characterization of these antibodies are revealing how they recognize the envelope glycoprotein spike. Broadly reactive neutralizing antibodies utilize just a few sites of spike vulnerability and converge on select modes of recognition. These antibodies have unusual features: uncommonly long complementarity-determining loops, extensive somatic mutation, or both. Recent advances in next-generation sequencing of antibody-gene transcripts are providing genetic records of the development of neutralizing antibodies. These records inform an understanding of the naive B cell repertoire, of somatic mutation, and of the resulting antibody features that are critical to effective HIV-1 neutralization; based on these, we propose an ontogeny and structure-based system of antibody classification. The human immune system is capable of developing antibodies that broadly neutralize HIV-1--and an increasingly detailed view is accumulating for how effective immunity against HIV-1 can be generated." @default.
- W2029135056 created "2016-06-24" @default.
- W2029135056 creator A5043677118 @default.
- W2029135056 creator A5071657202 @default.
- W2029135056 date "2012-09-01" @default.
- W2029135056 modified "2023-10-17" @default.
- W2029135056 title "Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies" @default.
- W2029135056 cites W1534972788 @default.
- W2029135056 cites W1607133945 @default.
- W2029135056 cites W1628484047 @default.
- W2029135056 cites W1794879226 @default.
- W2029135056 cites W1819175834 @default.
- W2029135056 cites W1969156908 @default.
- W2029135056 cites W1969644422 @default.
- W2029135056 cites W1970266002 @default.
- W2029135056 cites W1971233211 @default.
- W2029135056 cites W1974138678 @default.
- W2029135056 cites W1974273518 @default.
- W2029135056 cites W1979882766 @default.
- W2029135056 cites W1983551402 @default.
- W2029135056 cites W1985534966 @default.
- W2029135056 cites W1992566288 @default.
- W2029135056 cites W1992888167 @default.
- W2029135056 cites W1993366615 @default.
- W2029135056 cites W1995355944 @default.
- W2029135056 cites W1995466180 @default.
- W2029135056 cites W1995587280 @default.
- W2029135056 cites W1997677784 @default.
- W2029135056 cites W1997989849 @default.
- W2029135056 cites W2000361373 @default.
- W2029135056 cites W2002193732 @default.
- W2029135056 cites W2005559705 @default.
- W2029135056 cites W2006483986 @default.
- W2029135056 cites W2009151161 @default.
- W2029135056 cites W2010996470 @default.
- W2029135056 cites W2011136801 @default.
- W2029135056 cites W2013330052 @default.
- W2029135056 cites W2016364569 @default.
- W2029135056 cites W2016453064 @default.
- W2029135056 cites W2018123062 @default.
- W2029135056 cites W2020100193 @default.
- W2029135056 cites W2020596573 @default.
- W2029135056 cites W2023388704 @default.
- W2029135056 cites W2025005245 @default.
- W2029135056 cites W2026154428 @default.
- W2029135056 cites W2033645653 @default.
- W2029135056 cites W2034160159 @default.
- W2029135056 cites W2038535315 @default.
- W2029135056 cites W2039970562 @default.
- W2029135056 cites W2040889536 @default.
- W2029135056 cites W2049810408 @default.
- W2029135056 cites W2051364248 @default.
- W2029135056 cites W2053127269 @default.
- W2029135056 cites W2057119574 @default.
- W2029135056 cites W2058632331 @default.
- W2029135056 cites W2062204035 @default.
- W2029135056 cites W2062537390 @default.
- W2029135056 cites W2063701397 @default.
- W2029135056 cites W2067474031 @default.
- W2029135056 cites W2068310820 @default.
- W2029135056 cites W2070086938 @default.
- W2029135056 cites W2076198413 @default.
- W2029135056 cites W2077977162 @default.
- W2029135056 cites W2080089116 @default.
- W2029135056 cites W2080746125 @default.
- W2029135056 cites W2081291921 @default.
- W2029135056 cites W2083094268 @default.
- W2029135056 cites W2083726777 @default.
- W2029135056 cites W2084310667 @default.
- W2029135056 cites W2090763940 @default.
- W2029135056 cites W2091572749 @default.
- W2029135056 cites W2094829985 @default.
- W2029135056 cites W2095497026 @default.
- W2029135056 cites W2095910488 @default.
- W2029135056 cites W2097594050 @default.
- W2029135056 cites W2098781795 @default.
- W2029135056 cites W2102548388 @default.
- W2029135056 cites W2103360085 @default.
- W2029135056 cites W2103712192 @default.
- W2029135056 cites W2107723887 @default.
- W2029135056 cites W2109229894 @default.
- W2029135056 cites W2110917275 @default.
- W2029135056 cites W2111914135 @default.
- W2029135056 cites W2113236498 @default.
- W2029135056 cites W2115951500 @default.
- W2029135056 cites W2118274231 @default.
- W2029135056 cites W2121096721 @default.
- W2029135056 cites W2122210861 @default.
- W2029135056 cites W2122617162 @default.
- W2029135056 cites W2123708888 @default.
- W2029135056 cites W2124935744 @default.
- W2029135056 cites W2126654882 @default.
- W2029135056 cites W2126887491 @default.
- W2029135056 cites W2128461524 @default.
- W2029135056 cites W2128579789 @default.
- W2029135056 cites W2131039822 @default.
- W2029135056 cites W2135151522 @default.
- W2029135056 cites W2137939749 @default.