FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029137943> ?p ?o ?g. }

• W2029137943 endingPage "144" @default.
• W2029137943 startingPage "138" @default.
• W2029137943 abstract "The mechanism by which psoralen is transported across the placenta was investigated in the BeWo human placental cell line derived from choriocarcinoma in a transwell assay system using liquid chromatography-mass spectrometry/mass spectrometry detection. Psoralen uptake by BeWo cells increased linearly over the concentration range of 0.01 µM to 100 µM (<i>r</i> ² = 0.997) and was not saturable. Psoralen uptake by BeWo cells was not affected by temperature (4 °C, room temperature, and 37 °C; p > 0.05). Psoralen transport increased linearly over 180 min (<i>r</i> ² = 0.988) with 3.08 ± 0.26 %, 5.47 ± 0.21 %, 7.54 ± 0.06 %, 9.40 ± 0.37 %, 11.49 ± 0.31 %, and 12.46 ± 0.61 % transferred from the apical chamber to the basolateral chamber in the transwell assays at 30, 60, 90, 120, 150, and 180 min, respectively. The rate of transport showed the same tendency, increasing linearly from 0.13 ± 0.01 pmol/s to 0.58 ± 0.03 pmol/s over the concentration range of 25 µM to 100 µM (<i>r</i> ² = 0.989). The apparent permeability coefficient for psoralen (100 µM) was 5.62 ± 0.24 × 10⁻⁶ cm/s and 5.53 ± 0.47 × 10⁻⁶ cm/s before and after treatment with verapamil (100 µM), respectively (p > 0.05). The efflux value for psoralen was approximately 1. These data show that psoralen is well absorbed and crosses the placental barrier via passive diffusion in the BeWo cell line." @default.
• W2029137943 created "2016-06-24" @default.
• W2029137943 creator A5000479471 @default.
• W2029137943 creator A5004716253 @default.
• W2029137943 creator A5009530681 @default.
• W2029137943 creator A5015620326 @default.
• W2029137943 creator A5031986067 @default.
• W2029137943 creator A5042533031 @default.
• W2029137943 creator A5082796482 @default.
• W2029137943 date "2015-01-27" @default.
• W2029137943 modified "2023-10-13" @default.
• W2029137943 title "In Vitro Transport Mechanism of Psoralen in a Human Placental Cell Line (BeWo Cells)" @default.
• W2029137943 doi "https://doi.org/10.1055/s-0034-1396147" @default.
• W2029137943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25626141" @default.
• W2029137943 hasPublicationYear "2015" @default.
• W2029137943 type Work @default.
• W2029137943 sameAs 2029137943 @default.
• W2029137943 citedByCount "6" @default.
• W2029137943 countsByYear W20291379432018 @default.
• W2029137943 countsByYear W20291379432019 @default.
• W2029137943 countsByYear W20291379432020 @default.
• W2029137943 countsByYear W20291379432023 @default.
• W2029137943 crossrefType "journal-article" @default.
• W2029137943 hasAuthorship W2029137943A5000479471 @default.
• W2029137943 hasAuthorship W2029137943A5004716253 @default.
• W2029137943 hasAuthorship W2029137943A5009530681 @default.
• W2029137943 hasAuthorship W2029137943A5015620326 @default.
• W2029137943 hasAuthorship W2029137943A5031986067 @default.
• W2029137943 hasAuthorship W2029137943A5042533031 @default.
• W2029137943 hasAuthorship W2029137943A5082796482 @default.
• W2029137943 hasConcept C113196181 @default.
• W2029137943 hasConcept C12554922 @default.
• W2029137943 hasConcept C153911025 @default.
• W2029137943 hasConcept C172680121 @default.
• W2029137943 hasConcept C185592680 @default.
• W2029137943 hasConcept C2776953305 @default.
• W2029137943 hasConcept C2779234561 @default.
• W2029137943 hasConcept C2781110370 @default.
• W2029137943 hasConcept C43617362 @default.
• W2029137943 hasConcept C54355233 @default.
• W2029137943 hasConcept C552990157 @default.
• W2029137943 hasConcept C55493867 @default.
• W2029137943 hasConcept C86803240 @default.
• W2029137943 hasConceptScore W2029137943C113196181 @default.
• W2029137943 hasConceptScore W2029137943C12554922 @default.
• W2029137943 hasConceptScore W2029137943C153911025 @default.
• W2029137943 hasConceptScore W2029137943C172680121 @default.
• W2029137943 hasConceptScore W2029137943C185592680 @default.
• W2029137943 hasConceptScore W2029137943C2776953305 @default.
• W2029137943 hasConceptScore W2029137943C2779234561 @default.
• W2029137943 hasConceptScore W2029137943C2781110370 @default.
• W2029137943 hasConceptScore W2029137943C43617362 @default.
• W2029137943 hasConceptScore W2029137943C54355233 @default.
• W2029137943 hasConceptScore W2029137943C552990157 @default.
• W2029137943 hasConceptScore W2029137943C55493867 @default.
• W2029137943 hasConceptScore W2029137943C86803240 @default.
• W2029137943 hasIssue "02" @default.
• W2029137943 hasLocation W20291379431 @default.
• W2029137943 hasLocation W20291379432 @default.
• W2029137943 hasOpenAccess W2029137943 @default.
• W2029137943 hasPrimaryLocation W20291379431 @default.
• W2029137943 hasRelatedWork W2143839409 @default.
• W2029137943 hasRelatedWork W2159889268 @default.
• W2029137943 hasRelatedWork W2324538553 @default.
• W2029137943 hasRelatedWork W2330503608 @default.
• W2029137943 hasRelatedWork W2356701353 @default.
• W2029137943 hasRelatedWork W2368231724 @default.
• W2029137943 hasRelatedWork W2370389737 @default.
• W2029137943 hasRelatedWork W2389744986 @default.
• W2029137943 hasRelatedWork W2391185102 @default.
• W2029137943 hasRelatedWork W3147749385 @default.
• W2029137943 hasVolume "81" @default.
• W2029137943 isParatext "false" @default.
• W2029137943 isRetracted "false" @default.
• W2029137943 magId "2029137943" @default.
• W2029137943 workType "article" @default.