FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029138997> ?p ?o ?g. }

• W2029138997 endingPage "1192" @default.
• W2029138997 startingPage "1185" @default.
• W2029138997 abstract "ObjectiveWe examined the stimulatory effect of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet production in male (NZW × BXSB) Fl (W/B F1) mice, a murine model of idiopathic thrombocytopenic purpura.Materials and MethodsA cohort of 19- to 25-week-old, severely thrombocytopenic male W/B F1 mice were given PEG-rHuMGDF at different dosing schedules. Before and at various times after therapy, platelet counts, reticulated platelets, platelet lifespan, and levels of platelet-associated immunoglobulin G were measured. Analysis of megakaryocytic cells was performed.ResultsTreatment of male W/B F1 mice with PEG-rHuMGDF (30 μg/kg/day) three times per week for several weeks resulted in sustained thrombocytosis, accompanied by increased megakaryocytopoiesis in both the bone marrow and spleen. The degree of the platelet response to PEG-rHuMGDF varied between individual mice, likely reflecting the heterogeneity of the disease. Production of new platelets in response to PEG-rHuMGDF was manifested by an increase in reticulated platelets. Levels of platelet-associated immunoglobulin G decreased inversely during periods of thrombocytosis. PEG-rHuMGDF therapy also improved thrombocytopenia in male W/B F1 mice refractory to splenectomy. Platelet lifespan was not affected by PEG-rHuMGDF. Male W/B F1 mice treated with pegylated murine MGDF, a homologue of PEG-rHuMGDF, had persistent thrombocytosis for at least 7 months, suggesting that antiplatelet antibody production was not enhanced.ConclusionPEG-rHuMGDF therapy potently stimulated platelet production, effectively ameliorating thrombocytopenia in a murine model of idiopathic thrombocytopenic purpura." @default.
• W2029138997 created "2016-06-24" @default.
• W2029138997 creator A5019303848 @default.
• W2029138997 creator A5038268337 @default.
• W2029138997 creator A5039153858 @default.
• W2029138997 creator A5039826617 @default.
• W2029138997 creator A5045269393 @default.
• W2029138997 creator A5076742869 @default.
• W2029138997 creator A5076054400 @default.
• W2029138997 date "2002-10-01" @default.
• W2029138997 modified "2023-10-16" @default.
• W2029138997 title "Marked improvement of thrombocytopenia in a murine model of idiopathic thrombocytopenic purpura by pegylated recombinant human megakaryocyte growth and development factor" @default.
• W2029138997 cites W168471380 @default.
• W2029138997 cites W173282636 @default.
• W2029138997 cites W1865033903 @default.
• W2029138997 cites W193519295 @default.
• W2029138997 cites W1979820418 @default.
• W2029138997 cites W1983612778 @default.
• W2029138997 cites W1987686674 @default.
• W2029138997 cites W2025122282 @default.
• W2029138997 cites W2038818733 @default.
• W2029138997 cites W2044641494 @default.
• W2029138997 cites W2056147490 @default.
• W2029138997 cites W2061382718 @default.
• W2029138997 cites W2078173245 @default.
• W2029138997 cites W2079807050 @default.
• W2029138997 cites W2081185151 @default.
• W2029138997 cites W2089468267 @default.
• W2029138997 cites W2118599141 @default.
• W2029138997 cites W2143531841 @default.
• W2029138997 cites W2266255187 @default.
• W2029138997 cites W2279200935 @default.
• W2029138997 cites W2288265765 @default.
• W2029138997 cites W2317912629 @default.
• W2029138997 cites W2400897437 @default.
• W2029138997 cites W2416394440 @default.
• W2029138997 cites W247127784 @default.
• W2029138997 cites W3117542354 @default.
• W2029138997 cites W3148709400 @default.
• W2029138997 cites W348221760 @default.
• W2029138997 cites W4299587195 @default.
• W2029138997 doi "https://doi.org/10.1016/s0301-472x(02)00898-6" @default.
• W2029138997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12384150" @default.
• W2029138997 hasPublicationYear "2002" @default.
• W2029138997 type Work @default.
• W2029138997 sameAs 2029138997 @default.
• W2029138997 citedByCount "3" @default.
• W2029138997 countsByYear W20291389972013 @default.
• W2029138997 countsByYear W20291389972014 @default.
• W2029138997 crossrefType "journal-article" @default.
• W2029138997 hasAuthorship W2029138997A5019303848 @default.
• W2029138997 hasAuthorship W2029138997A5038268337 @default.
• W2029138997 hasAuthorship W2029138997A5039153858 @default.
• W2029138997 hasAuthorship W2029138997A5039826617 @default.
• W2029138997 hasAuthorship W2029138997A5045269393 @default.
• W2029138997 hasAuthorship W2029138997A5076054400 @default.
• W2029138997 hasAuthorship W2029138997A5076742869 @default.
• W2029138997 hasBestOaLocation W20291389971 @default.
• W2029138997 hasConcept C109159458 @default.
• W2029138997 hasConcept C126322002 @default.
• W2029138997 hasConcept C134018914 @default.
• W2029138997 hasConcept C203014093 @default.
• W2029138997 hasConcept C2776309230 @default.
• W2029138997 hasConcept C2776958478 @default.
• W2029138997 hasConcept C2777863708 @default.
• W2029138997 hasConcept C2777918643 @default.
• W2029138997 hasConcept C2779705218 @default.
• W2029138997 hasConcept C2779771385 @default.
• W2029138997 hasConcept C2779788118 @default.
• W2029138997 hasConcept C2780931953 @default.
• W2029138997 hasConcept C28328180 @default.
• W2029138997 hasConcept C54355233 @default.
• W2029138997 hasConcept C71924100 @default.
• W2029138997 hasConcept C86803240 @default.
• W2029138997 hasConcept C89560881 @default.
• W2029138997 hasConceptScore W2029138997C109159458 @default.
• W2029138997 hasConceptScore W2029138997C126322002 @default.
• W2029138997 hasConceptScore W2029138997C134018914 @default.
• W2029138997 hasConceptScore W2029138997C203014093 @default.
• W2029138997 hasConceptScore W2029138997C2776309230 @default.
• W2029138997 hasConceptScore W2029138997C2776958478 @default.
• W2029138997 hasConceptScore W2029138997C2777863708 @default.
• W2029138997 hasConceptScore W2029138997C2777918643 @default.
• W2029138997 hasConceptScore W2029138997C2779705218 @default.
• W2029138997 hasConceptScore W2029138997C2779771385 @default.
• W2029138997 hasConceptScore W2029138997C2779788118 @default.
• W2029138997 hasConceptScore W2029138997C2780931953 @default.
• W2029138997 hasConceptScore W2029138997C28328180 @default.
• W2029138997 hasConceptScore W2029138997C54355233 @default.
• W2029138997 hasConceptScore W2029138997C71924100 @default.
• W2029138997 hasConceptScore W2029138997C86803240 @default.
• W2029138997 hasConceptScore W2029138997C89560881 @default.
• W2029138997 hasIssue "10" @default.
• W2029138997 hasLocation W20291389971 @default.
• W2029138997 hasLocation W20291389972 @default.
• W2029138997 hasOpenAccess W2029138997 @default.
• W2029138997 hasPrimaryLocation W20291389971 @default.
• W2029138997 hasRelatedWork W1974301854 @default.

• next