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- W2029139610 abstract "The pulse frequency, amplitude, and mode of administration of GnRH all influence gonadotropin secretion and, ultimately, pituitary-gonadal function. We studied plasma LH responses to repetitive iv administration of GnRH given hourly for 5 h as a 2-μg rapid (<15 s) bolus dose or a 2-μg dose infused for 15 min of each hour in seven women deficient in endogenous GnRH and sex steroids. Plasma LH levels, measured at 10-min intervals throughout the 5-h period, rose more briskly (pattern × time course interaction: F = 3.33; P < 0.0001) to higher levels overall (F = 11.7; P = 0.014) after rapid bolus GnRH administration than after GnRH infusion. Plasma FSH levels increased during both modes of delivery, with higher responses to rapid bolus GnRH administration (P = 0.005). Plasma estradiol levels did not change during either 5-h study. We conclude that the pattern of delivery of GnRH is a determinant of pituitary LH and FSH secretion in untreated hypogonadotropic women, and therefore, that alterations in the GnRH wave form and/or peak plasma GnRH concentrations consequent upon different rates of GnRH entry into the bloodstream may explain the different responses that occur when GnRH is given by different routes." @default.
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- W2029139610 date "1988-07-01" @default.
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- W2029139610 title "Pharmacodynamics of Gonadotropin-Releasing Hormone (GnRH). II. Pattern of GnRH Delivery Alters Pituitary Luteinizing Hormone Secretion in Women*" @default.
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- W2029139610 doi "https://doi.org/10.1210/jcem-67-1-175" @default.
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