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• W2029142207 abstract "To explore the anti-inflammatory effects of a novel peptide designed to bind with the NF-kappaB p50 subunit.The affinity of the peptide binding with p50 was measured with a biosensor. Levels of tumor necrosis factor-alpha(TNF-alpha) and interleukin 6 (IL-6) from a human acute monocytic leukemia cell line (THP-1) treated with lipopolysaccharide (LPS) were measured using the ELISA method. In vivo anti-inflammatory effects of the peptide were tested with phorbol myristate acetate (PMA)-induced ear edema and zymosan A-induced peritonitis in mice.The peptide has the ability to interact with the NF-kappaB p50 subunit and can effectively inhibit TNF-alpha and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice.The peptide may have therapeutic potential for the treatment of local acute inflammation." @default.
• W2029142207 created "2016-06-24" @default.
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• W2029142207 date "2006-11-01" @default.
• W2029142207 modified "2023-10-05" @default.
• W2029142207 title "Anti-inflammatory effects of a novel peptide designed to bind with NF-?B p50 subunit" @default.
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• W2029142207 doi "https://doi.org/10.1111/j.1745-7254.2006.00442.x" @default.
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