FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029142438> ?p ?o ?g. }

• W2029142438 abstract "Three half-ester derivatives 10-12 of 5'-O-2',3'-dideoxydidanosine (DDI, 1) have been synthesized. The compounds exhibited excellent correlation between partition coefficients LogP and relative in vitro bovine serum albumin binding. Using high-performance liquid chromatography-mass spectrometry (LC-MS), DDI (1) was quantitatively determined in rat plasma after intravenous injection of the azelaic acid monoester derivative (11) of DDI. The pharmacokinetic data obtained for DDI were consistent with literature. The pharmacokinetic profile of 11 showed no significant difference in AUC(0-360) or curve shape compared to the parent drug DDI (1). The data indicate that the prodrug was converted to DDI within minutes after administration. High relative protein binding in vitro holds a promise for validity of the concept using more stable linker bonds." @default.
• W2029142438 created "2016-06-24" @default.
• W2029142438 creator A5008989094 @default.
• W2029142438 creator A5012578202 @default.
• W2029142438 creator A5023161275 @default.
• W2029142438 creator A5027383609 @default.
• W2029142438 creator A5032360367 @default.
• W2029142438 creator A5042053439 @default.
• W2029142438 creator A5063781924 @default.
• W2029142438 creator A5069118119 @default.
• W2029142438 creator A5073286913 @default.
• W2029142438 date "2009-10-01" @default.
• W2029142438 modified "2023-09-28" @default.
• W2029142438 title "Didanosine ester prodrugs: Synthesis, albumin binding properties and pharmacokinetic studies in rats" @default.
• W2029142438 cites W1566111314 @default.
• W2029142438 cites W1575542562 @default.
• W2029142438 cites W18810507 @default.
• W2029142438 cites W1917168236 @default.
• W2029142438 cites W1939656953 @default.
• W2029142438 cites W1968819700 @default.
• W2029142438 cites W1979266488 @default.
• W2029142438 cites W1985209842 @default.
• W2029142438 cites W1987380529 @default.
• W2029142438 cites W1992728523 @default.
• W2029142438 cites W1999784794 @default.
• W2029142438 cites W2002516695 @default.
• W2029142438 cites W2005847952 @default.
• W2029142438 cites W2007509278 @default.
• W2029142438 cites W200893942 @default.
• W2029142438 cites W2009968445 @default.
• W2029142438 cites W2021280139 @default.
• W2029142438 cites W2041123641 @default.
• W2029142438 cites W2041780922 @default.
• W2029142438 cites W2044839807 @default.
• W2029142438 cites W2045290283 @default.
• W2029142438 cites W2050067561 @default.
• W2029142438 cites W2050608724 @default.
• W2029142438 cites W2059843617 @default.
• W2029142438 cites W2061453818 @default.
• W2029142438 cites W2067617284 @default.
• W2029142438 cites W2079830327 @default.
• W2029142438 cites W2082247577 @default.
• W2029142438 cites W2119455404 @default.
• W2029142438 cites W2119525655 @default.
• W2029142438 cites W2133698009 @default.
• W2029142438 cites W2147235745 @default.
• W2029142438 cites W2155765426 @default.
• W2029142438 cites W2167528779 @default.
• W2029142438 cites W2209147002 @default.
• W2029142438 cites W2301978359 @default.
• W2029142438 cites W581679233 @default.
• W2029142438 cites W88005891 @default.
• W2029142438 doi "https://doi.org/10.1016/j.ejmech.2009.04.008" @default.
• W2029142438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19433342" @default.
• W2029142438 hasPublicationYear "2009" @default.
• W2029142438 type Work @default.
• W2029142438 sameAs 2029142438 @default.
• W2029142438 citedByCount "6" @default.
• W2029142438 countsByYear W20291424382012 @default.
• W2029142438 countsByYear W20291424382014 @default.
• W2029142438 countsByYear W20291424382015 @default.
• W2029142438 crossrefType "journal-article" @default.
• W2029142438 hasAuthorship W2029142438A5008989094 @default.
• W2029142438 hasAuthorship W2029142438A5012578202 @default.
• W2029142438 hasAuthorship W2029142438A5023161275 @default.
• W2029142438 hasAuthorship W2029142438A5027383609 @default.
• W2029142438 hasAuthorship W2029142438A5032360367 @default.
• W2029142438 hasAuthorship W2029142438A5042053439 @default.
• W2029142438 hasAuthorship W2029142438A5063781924 @default.
• W2029142438 hasAuthorship W2029142438A5069118119 @default.
• W2029142438 hasAuthorship W2029142438A5073286913 @default.
• W2029142438 hasConcept C108215921 @default.
• W2029142438 hasConcept C111919701 @default.
• W2029142438 hasConcept C112705442 @default.
• W2029142438 hasConcept C162356407 @default.
• W2029142438 hasConcept C185592680 @default.
• W2029142438 hasConcept C202751555 @default.
• W2029142438 hasConcept C2776125364 @default.
• W2029142438 hasConcept C2780557392 @default.
• W2029142438 hasConcept C41008148 @default.
• W2029142438 hasConcept C43617362 @default.
• W2029142438 hasConcept C55493867 @default.
• W2029142438 hasConcept C64489805 @default.
• W2029142438 hasConcept C71240020 @default.
• W2029142438 hasConcept C71924100 @default.
• W2029142438 hasConcept C86807702 @default.
• W2029142438 hasConcept C98274493 @default.
• W2029142438 hasConceptScore W2029142438C108215921 @default.
• W2029142438 hasConceptScore W2029142438C111919701 @default.
• W2029142438 hasConceptScore W2029142438C112705442 @default.
• W2029142438 hasConceptScore W2029142438C162356407 @default.
• W2029142438 hasConceptScore W2029142438C185592680 @default.
• W2029142438 hasConceptScore W2029142438C202751555 @default.
• W2029142438 hasConceptScore W2029142438C2776125364 @default.
• W2029142438 hasConceptScore W2029142438C2780557392 @default.
• W2029142438 hasConceptScore W2029142438C41008148 @default.
• W2029142438 hasConceptScore W2029142438C43617362 @default.
• W2029142438 hasConceptScore W2029142438C55493867 @default.
• W2029142438 hasConceptScore W2029142438C64489805 @default.
• W2029142438 hasConceptScore W2029142438C71240020 @default.

• next