FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029145764> ?p ?o ?g. }

• W2029145764 endingPage "241" @default.
• W2029145764 startingPage "233" @default.
• W2029145764 abstract "Abstract Increased expression of insulin‐like growth factor‐I (IGF‐I) in embryonic neural progenitors in vivo has been shown to accelerate neuron proliferation in the neocortex. In the present study, the in vivo actions of (IGF‐I) on naturally occurring neuron death in the cerebral cortex were investigated during embryonic and early postnatal development in a line of transgenic (Tg) mice that overexpress IGF‐I in the brain, directed by nestin genomic regulatory elements, beginning at least as early as embryonic day (E) 13. The areal density of apoptotic cells ( N A , cells/mm 2 ) at E16 in the telencephalic wall of Tg and littermate control embryos was determined by immunostaining with an antibody specific for activated caspase‐3. Stereological analyses were conducted to measure the numerical density ( N V , cells/mm 3 ) and total number of immunoreactive apoptotic cells in the cerebral cortex of nestin/IGF‐I Tg and control mice at postnatal days (P) 0 and 5. The volume of cerebral cortex and both the N V and total number of all cortical neurons also were determined in both cerebral hemispheres at P0, P5 and P270. Apoptotic cells were rare in the embryonic telencephalic wall at E16. However, the overall N A of apoptotic cells was found to be significantly less by 46% in Tg embryos. The volume of the cerebral cortex was significantly greater in Tg mice at P0 (30%), P5 (13%) and P270 (26%). The total number of cortical neurons in Tg mice was significantly increased at P0 (29%), P5 (29%) and P270 (31%), although the N V of cortical neurons did not differ significantly between Tg and control mice at any age. Transgenic mice at P0 and P5 exhibited significant decreases in the N V of apoptotic cells in the cerebral cortex (31% and 39%, respectively). The vast majority of these apoptotic cells (>90%) were judged to be neurons by their morphological appearance. Increased expression of IGF‐I inhibits naturally occurring ( i.e. apoptotic) neuron death during early postnatal development of the cerebral cortex to a degree that sustains a persistent increase in total neuron number even in the adult animal." @default.
• W2029145764 created "2016-06-24" @default.
• W2029145764 creator A5017924092 @default.
• W2029145764 creator A5060905257 @default.
• W2029145764 creator A5074308227 @default.
• W2029145764 date "2007-03-24" @default.
• W2029145764 modified "2023-10-11" @default.
• W2029145764 title "Insulin‐like growth factor‐I (IGF‐I) inhibits neuronal apoptosis in the developing cerebral cortex <i>in vivo</i>" @default.
• W2029145764 cites W1520969765 @default.
• W2029145764 cites W1572909157 @default.
• W2029145764 cites W1577238749 @default.
• W2029145764 cites W1671067214 @default.
• W2029145764 cites W1864437270 @default.
• W2029145764 cites W1899341317 @default.
• W2029145764 cites W1965975162 @default.
• W2029145764 cites W1970864607 @default.
• W2029145764 cites W1975559459 @default.
• W2029145764 cites W1977100089 @default.
• W2029145764 cites W1987785848 @default.
• W2029145764 cites W1989346410 @default.
• W2029145764 cites W1990126994 @default.
• W2029145764 cites W1993902481 @default.
• W2029145764 cites W1995429251 @default.
• W2029145764 cites W1998493999 @default.
• W2029145764 cites W2001530843 @default.
• W2029145764 cites W2001769052 @default.
• W2029145764 cites W2003521668 @default.
• W2029145764 cites W2010363881 @default.
• W2029145764 cites W2019260069 @default.
• W2029145764 cites W2020005796 @default.
• W2029145764 cites W2021008086 @default.
• W2029145764 cites W2021338058 @default.
• W2029145764 cites W2024431507 @default.
• W2029145764 cites W2025805078 @default.
• W2029145764 cites W2030997373 @default.
• W2029145764 cites W2036158708 @default.
• W2029145764 cites W2041405883 @default.
• W2029145764 cites W2044175751 @default.
• W2029145764 cites W2050345028 @default.
• W2029145764 cites W2051215942 @default.
• W2029145764 cites W2063449007 @default.
• W2029145764 cites W2064784276 @default.
• W2029145764 cites W2072347484 @default.
• W2029145764 cites W2073179464 @default.
• W2029145764 cites W2075910196 @default.
• W2029145764 cites W2077492083 @default.
• W2029145764 cites W2080570820 @default.
• W2029145764 cites W2081560586 @default.
• W2029145764 cites W2092061953 @default.
• W2029145764 cites W2093055261 @default.
• W2029145764 cites W2105382539 @default.
• W2029145764 cites W2118742245 @default.
• W2029145764 cites W2119399526 @default.
• W2029145764 cites W2123852291 @default.
• W2029145764 cites W2127714237 @default.
• W2029145764 cites W2153647147 @default.
• W2029145764 cites W2154745705 @default.
• W2029145764 cites W2159436231 @default.
• W2029145764 cites W2163124631 @default.
• W2029145764 cites W4246917142 @default.
• W2029145764 cites W4255400470 @default.
• W2029145764 doi "https://doi.org/10.1016/j.ijdevneu.2007.03.004" @default.
• W2029145764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2255566" @default.
• W2029145764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17459648" @default.
• W2029145764 hasPublicationYear "2007" @default.
• W2029145764 type Work @default.
• W2029145764 sameAs 2029145764 @default.
• W2029145764 citedByCount "50" @default.
• W2029145764 countsByYear W20291457642012 @default.
• W2029145764 countsByYear W20291457642013 @default.
• W2029145764 countsByYear W20291457642014 @default.
• W2029145764 countsByYear W20291457642015 @default.
• W2029145764 countsByYear W20291457642016 @default.
• W2029145764 countsByYear W20291457642017 @default.
• W2029145764 countsByYear W20291457642018 @default.
• W2029145764 countsByYear W20291457642019 @default.
• W2029145764 countsByYear W20291457642020 @default.
• W2029145764 countsByYear W20291457642021 @default.
• W2029145764 countsByYear W20291457642022 @default.
• W2029145764 countsByYear W20291457642023 @default.
• W2029145764 crossrefType "journal-article" @default.
• W2029145764 hasAuthorship W2029145764A5017924092 @default.
• W2029145764 hasAuthorship W2029145764A5060905257 @default.
• W2029145764 hasAuthorship W2029145764A5074308227 @default.
• W2029145764 hasBestOaLocation W20291457642 @default.
• W2029145764 hasConcept C104317684 @default.
• W2029145764 hasConcept C126322002 @default.
• W2029145764 hasConcept C134018914 @default.
• W2029145764 hasConcept C136834591 @default.
• W2029145764 hasConcept C145103041 @default.
• W2029145764 hasConcept C150903083 @default.
• W2029145764 hasConcept C169760540 @default.
• W2029145764 hasConcept C170493617 @default.
• W2029145764 hasConcept C190283241 @default.
• W2029145764 hasConcept C201750760 @default.
• W2029145764 hasConcept C203014093 @default.
• W2029145764 hasConcept C204232928 @default.
• W2029145764 hasConcept C207001950 @default.

• next