Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029146274> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2029146274 endingPage "200" @default.
- W2029146274 startingPage "191" @default.
- W2029146274 abstract "Recent data indicate that the neurotoxic effects of organophosphate compounds, including those of the nerve agents VX and sarin, are not solely due to irreversible cholinesterase inhibition. in this study we applied the patch clamp technique to hippocampal neurons in culture and slices to investigate the effects of VX, sarin and huperzine A on transmitter release and the mechanisms related with such effects. the nerve agents VX and sarin at very low concentrations significantly reduced the evoked release of GABA and glutamate. This effect was dependent of the activation of muscarinic receptors. in the presence or absence of the Na* -channel blocker tetrodotoxin (TTX), VX increased the frequency of spontaneous glutamate and GABA-induced postsynaptic currents. the effect of VX on TTX-insensitive spontaneous currents appears to be unrelated to cholinesterase inhibition, because it could be detected even after cholinesterase was blocked by high concentrations of the nerve agent soman. the ability of the nerve gases to decrease evoked release of GABA and increase spontaneous transmitter release may underlie some of the neurotoxic effects of the compounds. Huperzine A did not affect spontaneous or evoked release of GABA and glutamate, suggesting that this compound may be a pure cholinesterase inhibitor and had no effect on postsynaptic GABAA or AMP A receptors" @default.
- W2029146274 created "2016-06-24" @default.
- W2029146274 creator A5018700498 @default.
- W2029146274 creator A5029099498 @default.
- W2029146274 creator A5082985493 @default.
- W2029146274 creator A5088696368 @default.
- W2029146274 creator A5089176746 @default.
- W2029146274 date "1998-01-01" @default.
- W2029146274 modified "2023-09-27" @default.
- W2029146274 title "An Analysis of Low Level Doses of Cholinesterase Inhibitors in Cultured Neurons and Hippocampal Slices of Rats" @default.
- W2029146274 cites W1565709800 @default.
- W2029146274 cites W1982943526 @default.
- W2029146274 cites W1993386424 @default.
- W2029146274 cites W2002175811 @default.
- W2029146274 cites W2011621207 @default.
- W2029146274 cites W2018885303 @default.
- W2029146274 cites W2019049150 @default.
- W2029146274 cites W2025365248 @default.
- W2029146274 cites W2036275477 @default.
- W2029146274 cites W2050058512 @default.
- W2029146274 cites W2079257658 @default.
- W2029146274 cites W349004021 @default.
- W2029146274 cites W406410643 @default.
- W2029146274 doi "https://doi.org/10.3109/01480549809007411" @default.
- W2029146274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10028411" @default.
- W2029146274 hasPublicationYear "1998" @default.
- W2029146274 type Work @default.
- W2029146274 sameAs 2029146274 @default.
- W2029146274 citedByCount "18" @default.
- W2029146274 countsByYear W20291462742015 @default.
- W2029146274 countsByYear W20291462742020 @default.
- W2029146274 countsByYear W20291462742022 @default.
- W2029146274 crossrefType "journal-article" @default.
- W2029146274 hasAuthorship W2029146274A5018700498 @default.
- W2029146274 hasAuthorship W2029146274A5029099498 @default.
- W2029146274 hasAuthorship W2029146274A5082985493 @default.
- W2029146274 hasAuthorship W2029146274A5088696368 @default.
- W2029146274 hasAuthorship W2029146274A5089176746 @default.
- W2029146274 hasConcept C12554922 @default.
- W2029146274 hasConcept C168258287 @default.
- W2029146274 hasConcept C170493617 @default.
- W2029146274 hasConcept C181199279 @default.
- W2029146274 hasConcept C185592680 @default.
- W2029146274 hasConcept C197341189 @default.
- W2029146274 hasConcept C2776741303 @default.
- W2029146274 hasConcept C2778706303 @default.
- W2029146274 hasConcept C2778816929 @default.
- W2029146274 hasConcept C2780266723 @default.
- W2029146274 hasConcept C2780292010 @default.
- W2029146274 hasConcept C31896038 @default.
- W2029146274 hasConcept C55493867 @default.
- W2029146274 hasConcept C61174792 @default.
- W2029146274 hasConcept C86803240 @default.
- W2029146274 hasConcept C98274493 @default.
- W2029146274 hasConceptScore W2029146274C12554922 @default.
- W2029146274 hasConceptScore W2029146274C168258287 @default.
- W2029146274 hasConceptScore W2029146274C170493617 @default.
- W2029146274 hasConceptScore W2029146274C181199279 @default.
- W2029146274 hasConceptScore W2029146274C185592680 @default.
- W2029146274 hasConceptScore W2029146274C197341189 @default.
- W2029146274 hasConceptScore W2029146274C2776741303 @default.
- W2029146274 hasConceptScore W2029146274C2778706303 @default.
- W2029146274 hasConceptScore W2029146274C2778816929 @default.
- W2029146274 hasConceptScore W2029146274C2780266723 @default.
- W2029146274 hasConceptScore W2029146274C2780292010 @default.
- W2029146274 hasConceptScore W2029146274C31896038 @default.
- W2029146274 hasConceptScore W2029146274C55493867 @default.
- W2029146274 hasConceptScore W2029146274C61174792 @default.
- W2029146274 hasConceptScore W2029146274C86803240 @default.
- W2029146274 hasConceptScore W2029146274C98274493 @default.
- W2029146274 hasIssue "sup1" @default.
- W2029146274 hasLocation W20291462741 @default.
- W2029146274 hasLocation W20291462742 @default.
- W2029146274 hasOpenAccess W2029146274 @default.
- W2029146274 hasPrimaryLocation W20291462741 @default.
- W2029146274 hasRelatedWork W1986494743 @default.
- W2029146274 hasRelatedWork W1993211322 @default.
- W2029146274 hasRelatedWork W2003565525 @default.
- W2029146274 hasRelatedWork W2010391702 @default.
- W2029146274 hasRelatedWork W2029263151 @default.
- W2029146274 hasRelatedWork W2036275477 @default.
- W2029146274 hasRelatedWork W2058292682 @default.
- W2029146274 hasRelatedWork W2083457591 @default.
- W2029146274 hasRelatedWork W2091417037 @default.
- W2029146274 hasRelatedWork W2382198582 @default.
- W2029146274 hasVolume "21" @default.
- W2029146274 isParatext "false" @default.
- W2029146274 isRetracted "false" @default.
- W2029146274 magId "2029146274" @default.
- W2029146274 workType "article" @default.