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• W2029147710 abstract "The PI3K/PTEN pathway plays a major role in carcinogenesis. Dysregulation of this pathway occurs frequently in breast cancer, and loss of PTEN expression is emerging as a potentially important mechanism of resistance to the widely used anti-HER2 therapy, trastuzumab. However, assays for loss of PTEN expression have suffered from lack of consistency. Here, we describe an automated and reliable protocol for PTEN protein expression by immunohistochemistry in formalin-fixed paraffin-embedded tissue that can be easily incorporated into clinical trials." @default.
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• W2029147710 date "2010-07-01" @default.
• W2029147710 modified "2023-09-23" @default.
• W2029147710 title "Protocol for PTEN Expression by Immunohistochemistry in Formalin-fixed Paraffin-embedded Human Breast Carcinoma" @default.
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• W2029147710 doi "https://doi.org/10.1097/pai.0b013e3181d50bd5" @default.
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