Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029149670> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2029149670 endingPage "845" @default.
- W2029149670 startingPage "841" @default.
- W2029149670 abstract "Livers of a natural population of winter flounder from a contaminated site in Boston Harbor were examined for the presence of oncogenes by transfection of DNA into NIH 3T3 mouse fibroblasts. Tissues analyzed contained histopathologic lesions including abnormal vacuolation, biliary proliferation, and, in many cases, hepatocellular and cholangiocellular carcinomas. Fibroblasts transfected with liver DNA samples from 7 of 13 diseased animals were effective in the induction of subcutaneous sarcomas in nude mice. Further analysis revealed the presence of flounder c-Ki-ras oncogenes in all 10 nude mouse subcutaneous tumors analyzed. Direct DNA sequencing and allele-specific oligonucleotide hybridization following amplification of the tumor DNA by the polymerase chain reaction showed mutations in the 12th codon in this gene. Analysis of DNA from all nude mouse tumors as well as the livers from which they were derived showed mutations at this codon. The mutations comprised G.C----A.T or G.C----T.A base changes resulting in substitution of serine, valine, or cysteine for glycine. Liver DNA samples from five histologically normal livers of animals from a less polluted site were ineffective in the transfection assay and showed only wild-type DNA sequences (GGT) at the 12th codon of c-Ki-ras. The prevalence of mutations in this gene region was associated with the presence of liver lesions and could signify DNA damage resulting from environmental chemical exposure." @default.
- W2029149670 created "2016-06-24" @default.
- W2029149670 creator A5023303257 @default.
- W2029149670 creator A5033587830 @default.
- W2029149670 creator A5034401273 @default.
- W2029149670 creator A5052579012 @default.
- W2029149670 creator A5069477348 @default.
- W2029149670 date "1990-01-01" @default.
- W2029149670 modified "2023-10-12" @default.
- W2029149670 title "Mutations in c-Ki-ras oncogenes in diseased livers of winter flounder from Boston Harbor." @default.
- W2029149670 cites W1533603781 @default.
- W2029149670 cites W1560539518 @default.
- W2029149670 cites W1808352992 @default.
- W2029149670 cites W1973677994 @default.
- W2029149670 cites W2014669590 @default.
- W2029149670 cites W2024084862 @default.
- W2029149670 cites W2030581552 @default.
- W2029149670 cites W2032118018 @default.
- W2029149670 cites W2042371773 @default.
- W2029149670 cites W2054554443 @default.
- W2029149670 cites W2077944409 @default.
- W2029149670 cites W2086046963 @default.
- W2029149670 cites W2087441022 @default.
- W2029149670 cites W2087884848 @default.
- W2029149670 cites W2146512448 @default.
- W2029149670 cites W2168131938 @default.
- W2029149670 cites W4232777855 @default.
- W2029149670 doi "https://doi.org/10.1073/pnas.87.2.841" @default.
- W2029149670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/53362" @default.
- W2029149670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2405390" @default.
- W2029149670 hasPublicationYear "1990" @default.
- W2029149670 type Work @default.
- W2029149670 sameAs 2029149670 @default.
- W2029149670 citedByCount "55" @default.
- W2029149670 countsByYear W20291496702012 @default.
- W2029149670 countsByYear W20291496702016 @default.
- W2029149670 countsByYear W20291496702023 @default.
- W2029149670 crossrefType "journal-article" @default.
- W2029149670 hasAuthorship W2029149670A5023303257 @default.
- W2029149670 hasAuthorship W2029149670A5033587830 @default.
- W2029149670 hasAuthorship W2029149670A5034401273 @default.
- W2029149670 hasAuthorship W2029149670A5052579012 @default.
- W2029149670 hasAuthorship W2029149670A5069477348 @default.
- W2029149670 hasBestOaLocation W20291496702 @default.
- W2029149670 hasConcept C104317684 @default.
- W2029149670 hasConcept C129312508 @default.
- W2029149670 hasConcept C153911025 @default.
- W2029149670 hasConcept C2908647359 @default.
- W2029149670 hasConcept C49105822 @default.
- W2029149670 hasConcept C501734568 @default.
- W2029149670 hasConcept C54009773 @default.
- W2029149670 hasConcept C54355233 @default.
- W2029149670 hasConcept C552990157 @default.
- W2029149670 hasConcept C71924100 @default.
- W2029149670 hasConcept C86803240 @default.
- W2029149670 hasConcept C99454951 @default.
- W2029149670 hasConceptScore W2029149670C104317684 @default.
- W2029149670 hasConceptScore W2029149670C129312508 @default.
- W2029149670 hasConceptScore W2029149670C153911025 @default.
- W2029149670 hasConceptScore W2029149670C2908647359 @default.
- W2029149670 hasConceptScore W2029149670C49105822 @default.
- W2029149670 hasConceptScore W2029149670C501734568 @default.
- W2029149670 hasConceptScore W2029149670C54009773 @default.
- W2029149670 hasConceptScore W2029149670C54355233 @default.
- W2029149670 hasConceptScore W2029149670C552990157 @default.
- W2029149670 hasConceptScore W2029149670C71924100 @default.
- W2029149670 hasConceptScore W2029149670C86803240 @default.
- W2029149670 hasConceptScore W2029149670C99454951 @default.
- W2029149670 hasIssue "2" @default.
- W2029149670 hasLocation W20291496701 @default.
- W2029149670 hasLocation W20291496702 @default.
- W2029149670 hasLocation W20291496703 @default.
- W2029149670 hasLocation W20291496704 @default.
- W2029149670 hasOpenAccess W2029149670 @default.
- W2029149670 hasPrimaryLocation W20291496701 @default.
- W2029149670 hasRelatedWork W1978794790 @default.
- W2029149670 hasRelatedWork W1980609410 @default.
- W2029149670 hasRelatedWork W2059862594 @default.
- W2029149670 hasRelatedWork W2361321344 @default.
- W2029149670 hasRelatedWork W2372521113 @default.
- W2029149670 hasRelatedWork W2380397090 @default.
- W2029149670 hasRelatedWork W2391256396 @default.
- W2029149670 hasRelatedWork W2392804297 @default.
- W2029149670 hasRelatedWork W2978251436 @default.
- W2029149670 hasRelatedWork W3157865522 @default.
- W2029149670 hasVolume "87" @default.
- W2029149670 isParatext "false" @default.
- W2029149670 isRetracted "false" @default.
- W2029149670 magId "2029149670" @default.
- W2029149670 workType "article" @default.