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• W2029149739 abstract "After their initial antigen encounter in the secondary lymphoid organs, activated T cells must receive additional signals in the peripheral tissues to fully differentiate. Here, we provide evidence that γ c cytokines are critical during this process. Using the Marilyn (Ml) T cell antigen receptor (TCR) transgenic model, we show that male skin grafts are tolerated in the absence of γ c , but that Ml CD4 + T cells proliferate normally in response to antigen, traffic to the graft site and recruit an inflammatory response [including natural killer (NK) cells, neutrophils, and macrophages] that is independent of T cell γ c expression. Whereas wild-type T cells demonstrate a progressive differentiation phenotype from the spleen to the tissues, skin-infiltrating effector T cells (CD44 hi CD62L lo ) from γ c − mice were phenotypically abnormal with reduced ICOS, NKG2D, granzyme B, and IFN-γ expression. These defects could be mapped to deficiencies in IL-2 and, surprisingly, IL-15. These results define a late checkpoint in T cell differentiation in the tissues where γ c cytokines, including IL-15, authenticate CD4 + T cell effector functions." @default.
• W2029149739 created "2016-06-24" @default.
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• W2029149739 date "2007-09-25" @default.
• W2029149739 modified "2023-10-18" @default.
• W2029149739 title " c cytokines condition the progressive differentiation of CD4+ T cells" @default.
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• W2029149739 doi "https://doi.org/10.1073/pnas.0702913104" @default.
• W2029149739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2000521" @default.
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