FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029162578> ?p ?o ?g. }

• W2029162578 endingPage "272" @default.
• W2029162578 startingPage "259" @default.
• W2029162578 abstract "The development of calmodulin stimulated protein phosphorylation, with particular reference to calmodulin-stimulated protein kinase II (CMK II), was investigated in 3 subcellular fractions of chicken forebrain: cytosol (S3), crude synaptic plasma membranes (P2-M) and occluded cytosol (P2-S). Changes in the level of calmodulin-stimulated phosphorylation of endogenous proteins occurred over a protracted time course and were not complete until after day 52 post-hatching. By day 15 post-hatching, calmodulin-stimulated phosphoproteins characteristic of embryonic fractions had all disappeared and those characteristic of adult tissue were present but not necessarily at their mature levels. The levels of CMK II were estimated from the autophosphorylation of the α-subunit which was the only phosphoprotein present at 53,000 Da in the 3 fractions. Overall, calmodulin-stimulated phosphorylation and CMK II levels were low in embryonic brain and high in adult brain but two specific changes in CMK II were observed during development: (1) although CMK II concentrations increased in both membrane and cytosolic fractions until day 23 the kinase was predominantly cytoplasmic (approximately 75%) until day 23, after which it became increasingly membrane bound so that by day 52 post-hatching the majority of CMK II was present in the synaptic membrane fraction, and (2) the relative concentrations of the α- and β-subunits changed from an α:β-value of approximately 1:1 in the 19 day embryo to approximately 1:2 by 15 days post-hatch after which no further change was seen. The occurrence of major changes in the calmodulin stimulated protein phosphorylation system for up to 6–8 weeks after synapse formation is completed in the forebrain, provides further support for the existence of a synapse maturation phase of neuronal differentiation which is distinct from synapse formation. This phase involves only a specific subset of the developmental changes occurring in the calmodulin-stimulated phosphorylation system." @default.
• W2029162578 created "2016-06-24" @default.
• W2029162578 creator A5072481066 @default.
• W2029162578 creator A5091406710 @default.
• W2029162578 date "1988-10-01" @default.
• W2029162578 modified "2023-09-26" @default.
• W2029162578 title "Developmental changes in protein phosphorylation in chicken forebrain. II. Calmodulin stimulated phosphorylation" @default.
• W2029162578 cites W1425504406 @default.
• W2029162578 cites W1480101062 @default.
• W2029162578 cites W1502235378 @default.
• W2029162578 cites W1503152793 @default.
• W2029162578 cites W1526920045 @default.
• W2029162578 cites W1530121834 @default.
• W2029162578 cites W1557683122 @default.
• W2029162578 cites W1597249542 @default.
• W2029162578 cites W1659153222 @default.
• W2029162578 cites W1775749144 @default.
• W2029162578 cites W1822174444 @default.
• W2029162578 cites W1963585906 @default.
• W2029162578 cites W1964964322 @default.
• W2029162578 cites W1972199495 @default.
• W2029162578 cites W1976669670 @default.
• W2029162578 cites W1978926494 @default.
• W2029162578 cites W1980643090 @default.
• W2029162578 cites W1982280946 @default.
• W2029162578 cites W1991006963 @default.
• W2029162578 cites W1996825405 @default.
• W2029162578 cites W2011656692 @default.
• W2029162578 cites W2017913498 @default.
• W2029162578 cites W2026523509 @default.
• W2029162578 cites W2027679341 @default.
• W2029162578 cites W2032298035 @default.
• W2029162578 cites W2034052740 @default.
• W2029162578 cites W2051272360 @default.
• W2029162578 cites W2072378554 @default.
• W2029162578 cites W2073358135 @default.
• W2029162578 cites W2075443858 @default.
• W2029162578 cites W2076657980 @default.
• W2029162578 cites W2090207315 @default.
• W2029162578 cites W2090984707 @default.
• W2029162578 cites W2093128447 @default.
• W2029162578 cites W2093294658 @default.
• W2029162578 cites W2094843865 @default.
• W2029162578 cites W2110546229 @default.
• W2029162578 cites W2131331811 @default.
• W2029162578 cites W2137957947 @default.
• W2029162578 cites W2146780617 @default.
• W2029162578 cites W2164358316 @default.
• W2029162578 cites W2335286373 @default.
• W2029162578 cites W4214949654 @default.
• W2029162578 cites W4239385187 @default.
• W2029162578 cites W4296759590 @default.
• W2029162578 doi "https://doi.org/10.1016/0165-3806(88)90104-6" @default.
• W2029162578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3179751" @default.
• W2029162578 hasPublicationYear "1988" @default.
• W2029162578 type Work @default.
• W2029162578 sameAs 2029162578 @default.
• W2029162578 citedByCount "22" @default.
• W2029162578 crossrefType "journal-article" @default.
• W2029162578 hasAuthorship W2029162578A5072481066 @default.
• W2029162578 hasAuthorship W2029162578A5091406710 @default.
• W2029162578 hasConcept C11960822 @default.
• W2029162578 hasConcept C126322002 @default.
• W2029162578 hasConcept C134018914 @default.
• W2029162578 hasConcept C150109051 @default.
• W2029162578 hasConcept C181199279 @default.
• W2029162578 hasConcept C2777061661 @default.
• W2029162578 hasConcept C2779715522 @default.
• W2029162578 hasConcept C29688787 @default.
• W2029162578 hasConcept C529278444 @default.
• W2029162578 hasConcept C55493867 @default.
• W2029162578 hasConcept C71924100 @default.
• W2029162578 hasConcept C86803240 @default.
• W2029162578 hasConcept C87325107 @default.
• W2029162578 hasConcept C95444343 @default.
• W2029162578 hasConcept C97029542 @default.
• W2029162578 hasConcept C98539663 @default.
• W2029162578 hasConceptScore W2029162578C11960822 @default.
• W2029162578 hasConceptScore W2029162578C126322002 @default.
• W2029162578 hasConceptScore W2029162578C134018914 @default.
• W2029162578 hasConceptScore W2029162578C150109051 @default.
• W2029162578 hasConceptScore W2029162578C181199279 @default.
• W2029162578 hasConceptScore W2029162578C2777061661 @default.
• W2029162578 hasConceptScore W2029162578C2779715522 @default.
• W2029162578 hasConceptScore W2029162578C29688787 @default.
• W2029162578 hasConceptScore W2029162578C529278444 @default.
• W2029162578 hasConceptScore W2029162578C55493867 @default.
• W2029162578 hasConceptScore W2029162578C71924100 @default.
• W2029162578 hasConceptScore W2029162578C86803240 @default.
• W2029162578 hasConceptScore W2029162578C87325107 @default.
• W2029162578 hasConceptScore W2029162578C95444343 @default.
• W2029162578 hasConceptScore W2029162578C97029542 @default.
• W2029162578 hasConceptScore W2029162578C98539663 @default.
• W2029162578 hasIssue "2" @default.
• W2029162578 hasLocation W20291625781 @default.
• W2029162578 hasLocation W20291625782 @default.
• W2029162578 hasOpenAccess W2029162578 @default.
• W2029162578 hasPrimaryLocation W20291625781 @default.

• next