FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029165714> ?p ?o ?g. }

• W2029165714 endingPage "226" @default.
• W2029165714 startingPage "218" @default.
• W2029165714 abstract "A mathematical model is presented for the kinetically controlled synthesis of cephalexin that describes the heterogeneous reaction-diffusion process involved in a batch reactor with glyoxyl-agarose immobilized penicillin acylase. The model is based on equations considering reaction and diffusion components. Reaction kinetics was considered according to the mechanism proposed by Schroën, while diffusion of the reacting species was described according to Fick's law. Intrinsic kinetic and diffusion parameters were experimentally determined in independent experiments. It was found that from the four kinetic constants, the one corresponding to the acyl-enzyme complex hydrolysis step had the greatest value, as previously reported by other authors. The effective diffusion coefficients of all substances were about 5×10(-10)m(2)/s, being 10% lower than free diffusion coefficients and therefore agreed with the highly porous structure of glyoxyl-agarose particles. Simulations made from the reaction-diffusion model equations were used to evaluate and analyze the impact of internal diffusional restrictions in function of catalyst enzyme loading and particle size. Increasing internal diffusional restrictions decreases the Cex synthesis/hydrolysis ratio, the conversion yield and the specific productivity. A nonlinear relationship between catalyst enzyme loading and specific productivity of Cex was obtained with the implication that an increase in catalyst enzyme loading will not increase the volumetric productivity by the same magnitude as it occurs with the free enzyme. Optimization of catalyst and reactor design should be done considering catalyst enzyme loading and particle size as the most important variables. The approach presented can be extended to other processes catalyzed by immobilized enzymes." @default.
• W2029165714 created "2016-06-24" @default.
• W2029165714 creator A5008124284 @default.
• W2029165714 creator A5020917721 @default.
• W2029165714 creator A5048257471 @default.
• W2029165714 creator A5053588576 @default.
• W2029165714 date "2012-01-01" @default.
• W2029165714 modified "2023-10-01" @default.
• W2029165714 title "Batch reactor performance for the enzymatic synthesis of cephalexin: influence of catalyst enzyme loading and particle size" @default.
• W2029165714 cites W1982344137 @default.
• W2029165714 cites W1993470367 @default.
• W2029165714 cites W2006128124 @default.
• W2029165714 cites W2018173841 @default.
• W2029165714 cites W2020101403 @default.
• W2029165714 cites W2041858537 @default.
• W2029165714 cites W2042969885 @default.
• W2029165714 cites W2075179823 @default.
• W2029165714 cites W2075728559 @default.
• W2029165714 cites W2077919158 @default.
• W2029165714 cites W2081433837 @default.
• W2029165714 cites W2082037029 @default.
• W2029165714 cites W2085101776 @default.
• W2029165714 cites W2116768986 @default.
• W2029165714 cites W2118125226 @default.
• W2029165714 cites W2121758307 @default.
• W2029165714 doi "https://doi.org/10.1016/j.nbt.2011.09.002" @default.
• W2029165714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21925630" @default.
• W2029165714 hasPublicationYear "2012" @default.
• W2029165714 type Work @default.
• W2029165714 sameAs 2029165714 @default.
• W2029165714 citedByCount "19" @default.
• W2029165714 countsByYear W20291657142014 @default.
• W2029165714 countsByYear W20291657142017 @default.
• W2029165714 countsByYear W20291657142018 @default.
• W2029165714 countsByYear W20291657142019 @default.
• W2029165714 countsByYear W20291657142020 @default.
• W2029165714 countsByYear W20291657142021 @default.
• W2029165714 countsByYear W20291657142022 @default.
• W2029165714 countsByYear W20291657142023 @default.
• W2029165714 crossrefType "journal-article" @default.
• W2029165714 hasAuthorship W2029165714A5008124284 @default.
• W2029165714 hasAuthorship W2029165714A5020917721 @default.
• W2029165714 hasAuthorship W2029165714A5048257471 @default.
• W2029165714 hasAuthorship W2029165714A5053588576 @default.
• W2029165714 hasConcept C111368507 @default.
• W2029165714 hasConcept C121332964 @default.
• W2029165714 hasConcept C127313418 @default.
• W2029165714 hasConcept C127413603 @default.
• W2029165714 hasConcept C134121241 @default.
• W2029165714 hasConcept C147789679 @default.
• W2029165714 hasConcept C148898269 @default.
• W2029165714 hasConcept C161790260 @default.
• W2029165714 hasConcept C178790620 @default.
• W2029165714 hasConcept C181199279 @default.
• W2029165714 hasConcept C185592680 @default.
• W2029165714 hasConcept C187530423 @default.
• W2029165714 hasConcept C2777451570 @default.
• W2029165714 hasConcept C2778476535 @default.
• W2029165714 hasConcept C2778517922 @default.
• W2029165714 hasConcept C33633552 @default.
• W2029165714 hasConcept C42360764 @default.
• W2029165714 hasConcept C43617362 @default.
• W2029165714 hasConcept C47502133 @default.
• W2029165714 hasConcept C62520636 @default.
• W2029165714 hasConcept C69357855 @default.
• W2029165714 hasConcept C94412978 @default.
• W2029165714 hasConcept C97355855 @default.
• W2029165714 hasConceptScore W2029165714C111368507 @default.
• W2029165714 hasConceptScore W2029165714C121332964 @default.
• W2029165714 hasConceptScore W2029165714C127313418 @default.
• W2029165714 hasConceptScore W2029165714C127413603 @default.
• W2029165714 hasConceptScore W2029165714C134121241 @default.
• W2029165714 hasConceptScore W2029165714C147789679 @default.
• W2029165714 hasConceptScore W2029165714C148898269 @default.
• W2029165714 hasConceptScore W2029165714C161790260 @default.
• W2029165714 hasConceptScore W2029165714C178790620 @default.
• W2029165714 hasConceptScore W2029165714C181199279 @default.
• W2029165714 hasConceptScore W2029165714C185592680 @default.
• W2029165714 hasConceptScore W2029165714C187530423 @default.
• W2029165714 hasConceptScore W2029165714C2777451570 @default.
• W2029165714 hasConceptScore W2029165714C2778476535 @default.
• W2029165714 hasConceptScore W2029165714C2778517922 @default.
• W2029165714 hasConceptScore W2029165714C33633552 @default.
• W2029165714 hasConceptScore W2029165714C42360764 @default.
• W2029165714 hasConceptScore W2029165714C43617362 @default.
• W2029165714 hasConceptScore W2029165714C47502133 @default.
• W2029165714 hasConceptScore W2029165714C62520636 @default.
• W2029165714 hasConceptScore W2029165714C69357855 @default.
• W2029165714 hasConceptScore W2029165714C94412978 @default.
• W2029165714 hasConceptScore W2029165714C97355855 @default.
• W2029165714 hasIssue "2" @default.
• W2029165714 hasLocation W20291657141 @default.
• W2029165714 hasLocation W20291657142 @default.
• W2029165714 hasOpenAccess W2029165714 @default.
• W2029165714 hasPrimaryLocation W20291657141 @default.
• W2029165714 hasRelatedWork W1995364324 @default.
• W2029165714 hasRelatedWork W2012156358 @default.
• W2029165714 hasRelatedWork W2054024686 @default.

• next