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- W2029165833 abstract "The genetic effects of UV light (UV) and UV followed by photoreactivation (UV + PR) have been studied in Neurospora crassa. A two-component heterokaryon was used to examine the effect of these 2 treatments on (1) inactivation of the heterokaryotic conidia, and (2) the induction of recessive lethal mutations at 2 specific loci. The heterokaryon is heterozygous for 2 closely linked loci, ad-3A and ad-3B, in the ad-3 region. The specific-locus mutations can result from either point mutation or chromosome deletion. After UV or UV + PR both point mutations and chromosome deletions were recovered in a ratio of about 24:1. Point mutations and chromosome deletions both increase as the square of the dose, so the spectrum of UV-induced mutation is dose-independent. These experiments also show that PR results in dose- reduction factors (DRFs) of about 0.6 at 60% survival for inactivation of conidia and 0.66 for the overall induction of ad-3 mutations. Genetic characterization of the ad-3 mutations showed no difference in the effect of PR on point mutations at the ad-3A or ad-3B locus; all subclasses of point mutations show a mean DRF of about o.66. Ad-3 mutations resulting from chromosome deletion, however, show a significantly lower mean DRF of about 0.50. These results show that PR has a greater effect on damage leading to chromosome deletions than on damage leading to point mutations. The difference between the DRFs obtained for point mutations and chromosome deletions is interpreted as an indication that they either result from qualitatively different lesions or from the same lesions repaired differentially." @default.
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- W2029165833 date "1971-07-01" @default.
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- W2029165833 title "Differential photoreversibility of ultraviolet-induced premutational lesions in neurospora" @default.
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- W2029165833 doi "https://doi.org/10.1016/0027-5107(71)90011-x" @default.
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