FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029173007> ?p ?o ?g. }

• W2029173007 endingPage "454" @default.
• W2029173007 startingPage "433" @default.
• W2029173007 abstract "Tritiated progesterone androstenedione and testosterone were incubated with testicular homogenates of 4- and 32-week-old Stanley-Gumbreck pseudohermaphrodite (Ps) and normal (N1) male littermate rats. In 15 and 180 minute incubations, both 4- and 32-week-old Ps testes converted all three substrates predominantly to androsterone and to a lesser extent androstanediol, while androstanediol in 4-week and testosterone in 32-week-old N1 testis were the major products. The addition of carrier testosterone (240 μg/g tissue) to 15 min incubations of testicular homogenates from 4- and 32-week-old N1 rats almost completely blocked the formation of androstanediol and markedly increased the accumulation of testosterone (47 and 41% from Progesterone-1,2- 3 H; 66 and 92% from androstenedione-l,2- 3 H) indicating that androstanediol formed in the absence of carrier testosterone is, most likely, a product of testosterone reduction. When similar incubations were repeated using testicular homogenates from 4- and 32-week-old Ps rats, testosterone accumulation was not greatly increased (4–11%) by the addition of carrier testosterone, but androsterone formation was completely inhibited. However, when the incubations of Progesterone-1 ,2- 3 H with 4- and 32-week-old Ps and N1 testis in the presence of carrier testosterone were continued for 180 min, the major fraction of radioactivity from 32-week-old N1 testis was testosterone (79%) while that from 4-week-old N1 testis was androstanediol (60%) and from 4-and 32-week-old Ps testis was both androsterone (44–45%) and androstanediol (22–33%). The present data indicate that 4-week-old Ps testis, like the N1, has a high level of ring A reductase activity but forms androsterone rather than androstanediol as its major product. Unlike the normal mature male rat testis, in which ring A reductase activity diminishes allowing testosterone to become the major product, the 32-week-old Ps testis maintains a high level of reductase activity." @default.
• W2029173007 created "2016-06-24" @default.
• W2029173007 creator A5023207208 @default.
• W2029173007 creator A5062631951 @default.
• W2029173007 creator A5078217401 @default.
• W2029173007 creator A5091276012 @default.
• W2029173007 date "1972-03-01" @default.
• W2029173007 modified "2023-10-18" @default.
• W2029173007 title "Steroid metabolism by testicular homogenates of the stanley-gumbreck pseudohermaphrodite male rat. I. increased formation of androsterone and androstanediol" @default.
• W2029173007 cites W1798874042 @default.
• W2029173007 cites W1994972429 @default.
• W2029173007 cites W1997963070 @default.
• W2029173007 cites W2000402184 @default.
• W2029173007 cites W2042743118 @default.
• W2029173007 cites W2046478212 @default.
• W2029173007 cites W2081640493 @default.
• W2029173007 cites W2123900478 @default.
• W2029173007 cites W2156955801 @default.
• W2029173007 doi "https://doi.org/10.1016/0039-128x(72)90080-3" @default.
• W2029173007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5028416" @default.
• W2029173007 hasPublicationYear "1972" @default.
• W2029173007 type Work @default.
• W2029173007 sameAs 2029173007 @default.
• W2029173007 citedByCount "19" @default.
• W2029173007 crossrefType "journal-article" @default.
• W2029173007 hasAuthorship W2029173007A5023207208 @default.
• W2029173007 hasAuthorship W2029173007A5062631951 @default.
• W2029173007 hasAuthorship W2029173007A5078217401 @default.
• W2029173007 hasAuthorship W2029173007A5091276012 @default.
• W2029173007 hasConcept C126322002 @default.
• W2029173007 hasConcept C134018914 @default.
• W2029173007 hasConcept C185592680 @default.
• W2029173007 hasConcept C2776683971 @default.
• W2029173007 hasConcept C2777911890 @default.
• W2029173007 hasConcept C2779279991 @default.
• W2029173007 hasConcept C2779746161 @default.
• W2029173007 hasConcept C2780902042 @default.
• W2029173007 hasConcept C2910306831 @default.
• W2029173007 hasConcept C62231903 @default.
• W2029173007 hasConcept C71315377 @default.
• W2029173007 hasConcept C71924100 @default.
• W2029173007 hasConcept C86803240 @default.
• W2029173007 hasConceptScore W2029173007C126322002 @default.
• W2029173007 hasConceptScore W2029173007C134018914 @default.
• W2029173007 hasConceptScore W2029173007C185592680 @default.
• W2029173007 hasConceptScore W2029173007C2776683971 @default.
• W2029173007 hasConceptScore W2029173007C2777911890 @default.
• W2029173007 hasConceptScore W2029173007C2779279991 @default.
• W2029173007 hasConceptScore W2029173007C2779746161 @default.
• W2029173007 hasConceptScore W2029173007C2780902042 @default.
• W2029173007 hasConceptScore W2029173007C2910306831 @default.
• W2029173007 hasConceptScore W2029173007C62231903 @default.
• W2029173007 hasConceptScore W2029173007C71315377 @default.
• W2029173007 hasConceptScore W2029173007C71924100 @default.
• W2029173007 hasConceptScore W2029173007C86803240 @default.
• W2029173007 hasIssue "3" @default.
• W2029173007 hasLocation W20291730071 @default.
• W2029173007 hasLocation W20291730072 @default.
• W2029173007 hasOpenAccess W2029173007 @default.
• W2029173007 hasPrimaryLocation W20291730071 @default.
• W2029173007 hasRelatedWork W1986311037 @default.
• W2029173007 hasRelatedWork W1987914672 @default.
• W2029173007 hasRelatedWork W1995975940 @default.
• W2029173007 hasRelatedWork W2002995968 @default.
• W2029173007 hasRelatedWork W2011535479 @default.
• W2029173007 hasRelatedWork W2024718203 @default.
• W2029173007 hasRelatedWork W2038277505 @default.
• W2029173007 hasRelatedWork W2060300693 @default.
• W2029173007 hasRelatedWork W2091289413 @default.
• W2029173007 hasRelatedWork W2144746424 @default.
• W2029173007 hasVolume "19" @default.
• W2029173007 isParatext "false" @default.
• W2029173007 isRetracted "false" @default.
• W2029173007 magId "2029173007" @default.
• W2029173007 workType "article" @default.