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- W2029173637 endingPage "2091" @default.
- W2029173637 startingPage "2081" @default.
- W2029173637 abstract "Abstract Serum creatinine does not share the properties of an ideal marker of glomerular filtration rate (GFR) like inulin, but continues to be the most widely used endogenous marker of GFR. In the search of a better biomarker of GFR, the small molecular weight protein cystatin C has been introduced with features more similar to that of inulin, such as constant production and no non-renal elimination. However, it has not enjoyed widespread use despite its significantly improved diagnostic performance in the detection of impaired GFR and its independence of body composition. A variety of formulae based on either cystatin C or creatinine or both have been developed to estimate GFR. We summarize the currently used methods of GFR measurement, their limitations and analytical errors. The review also summarizes the history, features and the feasibility of cystatin C measurements as well as the most widely used formulae for the estimation of GFR in children. The diagnostic performance of the cystatin C derived eGFR formulae at various levels of GFR is also discussed. An eGFR formula derived from pooled studies analyzing both creatinine and cystatin C, and using a biology-based mathematical approach may be advantageous." @default.
- W2029173637 created "2016-06-24" @default.
- W2029173637 creator A5042683401 @default.
- W2029173637 creator A5065533059 @default.
- W2029173637 creator A5079799210 @default.
- W2029173637 date "2012-07-06" @default.
- W2029173637 modified "2023-09-27" @default.
- W2029173637 title "The usefulness of cystatin C and related formulae in pediatrics" @default.
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