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- W2029173677 endingPage "2473" @default.
- W2029173677 startingPage "2467" @default.
- W2029173677 abstract "Ethyl-eicosapentaenoic acid (E-EPA) is an omega-3 fatty acid that has been used in a range of neuropsychiatric conditions with some benefits. However, its mechanism of action is unknown. Here, we investigate its effects on in vivo brain metabolism in first-episode psychosis (FEP). Proton magnetic resonance spectroscopy at 3 T was performed in the temporal lobes of 24 FEP patients before and after 12 weeks of treatment in the context of a larger double-blind, placebo-controlled E-EPA augmentation study. Treatment group effects for glutathione (F1,12=6.1, p=0.03), and a hemisphere-by-group interaction for glutamine/glutamate (F1,20=4.4, p=0.049) were found. Glutathione increased bilaterally and glutamate/glutamine increased in the left hemisphere following E-EPA administration. Improvement in negative symptoms correlated with metabolic brain changes, particularly glutathione (r=-0.57). These results suggest that E-EPA augmentation alters glutathione availability and modulates the glutamine/glutamate cycle in early psychosis, with some of the metabolic brain changes being correlated with negative symptom improvement. Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted." @default.
- W2029173677 created "2016-06-24" @default.
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- W2029173677 date "2008-01-16" @default.
- W2029173677 modified "2023-10-07" @default.
- W2029173677 title "Ethyl-Eicosapentaenoic Acid in First-Episode Psychosis. A 1H-MRS Study" @default.
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- W2029173677 doi "https://doi.org/10.1038/sj.npp.1301628" @default.
- W2029173677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18199999" @default.
- W2029173677 hasPublicationYear "2008" @default.
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