FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029174913> ?p ?o ?g. }

• W2029174913 endingPage "1254" @default.
• W2029174913 startingPage "1244" @default.
• W2029174913 abstract "In addition to its function as a neurotransmitter and vascular active molecule, serotonin is also a mitogen for hepatocytes and promotes liver regeneration. A possible role in hepatocellular cancer has not yet been investigated. Human hepatocellular cancer cell lines Huh7 and HepG2 were used to assess the function of serotonin in these cell lines. Characteristics of autophagy were detected with transmission electron microscopy, immunoblots of microtubule-associated protein light chain 3(LC3) and p62 (sequestosome 1). Immunoblots of the mammalian target of rapamycin (mTOR) and its downstream targets p70S6K and 4E-BP1 were used to investigate signaling pathways of serotonin. Two different animal models served as principle of proof of in vitro findings. Clinical relevance of the experimental findings was evaluated with a tissue microarray from 168 patients with hepatocellular carcinoma. Serotonin promotes tumor growth and survival in starved hepatocellular carcinoma cells. During starvation hepatocellular carcinoma cells exhibited characteristics of autophagy, which disappeared in serotonin-treated cells. Rapamycin, an inhibitor of mTOR, is known to induce autophagy. Serotonin could override rapamycin by an mTOR-independent pathway and activate common downstream signals such as p70S6K and 4E-BP1. In two tumor models of the mouse, inhibition of serotonin signaling consistently impaired tumor growth. Human biopsies revealed expression of the serotonin receptor HTR2B, correlating with downstream signals, e.g., phosphorylated p70S6K and proliferation. Conclusion: This study provides evidence that serotonin is involved in tumor growth of hepatocellular cancer by activating downstream targets of mTOR, and therefore serotonin-related pathways might represent a new treatment strategy. (HEPATOLOGY 2010.)" @default.
• W2029174913 created "2016-06-24" @default.
• W2029174913 creator A5013288631 @default.
• W2029174913 creator A5029760404 @default.
• W2029174913 creator A5051235246 @default.
• W2029174913 creator A5052578423 @default.
• W2029174913 creator A5070341110 @default.
• W2029174913 creator A5070904352 @default.
• W2029174913 creator A5074488110 @default.
• W2029174913 date "2009-11-20" @default.
• W2029174913 modified "2023-10-17" @default.
• W2029174913 title "Serotonin promotes tumor growth in human hepatocellular cancer" @default.
• W2029174913 cites W1508661542 @default.
• W2029174913 cites W1964628210 @default.
• W2029174913 cites W1967977853 @default.
• W2029174913 cites W1970060716 @default.
• W2029174913 cites W1972431686 @default.
• W2029174913 cites W1978367598 @default.
• W2029174913 cites W1987223917 @default.
• W2029174913 cites W1989204866 @default.
• W2029174913 cites W1994823455 @default.
• W2029174913 cites W1997993237 @default.
• W2029174913 cites W2001656004 @default.
• W2029174913 cites W2007486557 @default.
• W2029174913 cites W2010364329 @default.
• W2029174913 cites W2015376899 @default.
• W2029174913 cites W2020830322 @default.
• W2029174913 cites W2024952531 @default.
• W2029174913 cites W2030084215 @default.
• W2029174913 cites W2030102531 @default.
• W2029174913 cites W2039836319 @default.
• W2029174913 cites W2078893058 @default.
• W2029174913 cites W2080308963 @default.
• W2029174913 cites W2098073452 @default.
• W2029174913 cites W2109034822 @default.
• W2029174913 cites W2125027724 @default.
• W2029174913 cites W2134138119 @default.
• W2029174913 cites W2140153733 @default.
• W2029174913 cites W2141314162 @default.
• W2029174913 cites W4211260107 @default.
• W2029174913 cites W4254283855 @default.
• W2029174913 doi "https://doi.org/10.1002/hep.23441" @default.
• W2029174913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20099302" @default.
• W2029174913 hasPublicationYear "2009" @default.
• W2029174913 type Work @default.
• W2029174913 sameAs 2029174913 @default.
• W2029174913 citedByCount "170" @default.
• W2029174913 countsByYear W20291749132012 @default.
• W2029174913 countsByYear W20291749132013 @default.
• W2029174913 countsByYear W20291749132014 @default.
• W2029174913 countsByYear W20291749132015 @default.
• W2029174913 countsByYear W20291749132016 @default.
• W2029174913 countsByYear W20291749132017 @default.
• W2029174913 countsByYear W20291749132018 @default.
• W2029174913 countsByYear W20291749132019 @default.
• W2029174913 countsByYear W20291749132020 @default.
• W2029174913 countsByYear W20291749132021 @default.
• W2029174913 countsByYear W20291749132022 @default.
• W2029174913 countsByYear W20291749132023 @default.
• W2029174913 crossrefType "journal-article" @default.
• W2029174913 hasAuthorship W2029174913A5013288631 @default.
• W2029174913 hasAuthorship W2029174913A5029760404 @default.
• W2029174913 hasAuthorship W2029174913A5051235246 @default.
• W2029174913 hasAuthorship W2029174913A5052578423 @default.
• W2029174913 hasAuthorship W2029174913A5070341110 @default.
• W2029174913 hasAuthorship W2029174913A5070904352 @default.
• W2029174913 hasAuthorship W2029174913A5074488110 @default.
• W2029174913 hasBestOaLocation W20291749131 @default.
• W2029174913 hasConcept C126322002 @default.
• W2029174913 hasConcept C134018914 @default.
• W2029174913 hasConcept C170493617 @default.
• W2029174913 hasConcept C190283241 @default.
• W2029174913 hasConcept C203522944 @default.
• W2029174913 hasConcept C2775864247 @default.
• W2029174913 hasConcept C2777949483 @default.
• W2029174913 hasConcept C37000724 @default.
• W2029174913 hasConcept C502942594 @default.
• W2029174913 hasConcept C55493867 @default.
• W2029174913 hasConcept C62112901 @default.
• W2029174913 hasConcept C62478195 @default.
• W2029174913 hasConcept C71924100 @default.
• W2029174913 hasConcept C86554907 @default.
• W2029174913 hasConcept C86803240 @default.
• W2029174913 hasConcept C95444343 @default.
• W2029174913 hasConceptScore W2029174913C126322002 @default.
• W2029174913 hasConceptScore W2029174913C134018914 @default.
• W2029174913 hasConceptScore W2029174913C170493617 @default.
• W2029174913 hasConceptScore W2029174913C190283241 @default.
• W2029174913 hasConceptScore W2029174913C203522944 @default.
• W2029174913 hasConceptScore W2029174913C2775864247 @default.
• W2029174913 hasConceptScore W2029174913C2777949483 @default.
• W2029174913 hasConceptScore W2029174913C37000724 @default.
• W2029174913 hasConceptScore W2029174913C502942594 @default.
• W2029174913 hasConceptScore W2029174913C55493867 @default.
• W2029174913 hasConceptScore W2029174913C62112901 @default.
• W2029174913 hasConceptScore W2029174913C62478195 @default.
• W2029174913 hasConceptScore W2029174913C71924100 @default.
• W2029174913 hasConceptScore W2029174913C86554907 @default.

• next