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• W2029176287 startingPage "e19797" @default.
• W2029176287 abstract "The RNA-binding protein Hfq is recognized as an important regulatory factor in a variety of cellular processes, including stress resistance and pathogenesis. Hfq has been shown in several bacteria to interact with small regulatory RNAs and act as a post-transcriptional regulator of mRNA stability and translation. Here we examined the impact of Hfq on growth, stress tolerance, and gene expression in the intracellular pathogen Francisella novicida. We present evidence of Hfq involvement in the ability of F. novicida to tolerate several cellular stresses, including heat-shock and oxidative stresses, and alterations in hfq gene expression under these conditions. Furthermore, expression of numerous genes, including several associated with virulence, is altered in a hfq mutant strain suggesting they are regulated directly or indirectly by Hfq. Strikingly, we observed a delayed entry into stationary phase and increased biofilm formation in the hfq mutant. Together, these data demonstrate a critical role for Hfq in F. novicida growth and survival." @default.
• W2029176287 created "2016-06-24" @default.
• W2029176287 creator A5004995281 @default.
• W2029176287 creator A5091707494 @default.
• W2029176287 date "2011-05-05" @default.
• W2029176287 modified "2023-10-17" @default.
• W2029176287 title "The RNA Chaperone Hfq Is Important for Growth and Stress Tolerance in Francisella novicida" @default.
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• W2029176287 doi "https://doi.org/10.1371/journal.pone.0019797" @default.
• W2029176287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3088715" @default.
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• W2029176287 hasPublicationYear "2011" @default.
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