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- W2029185005 abstract "MicroRNAs (miRNAs) are endogenous transcripts that contain intramolecular double stranded RNA (dsRNA) and are processed by Dicer. Their mature products are approximately 21-24 nucleotides in length, and they collectively regulate a broad network of endogenous transcripts. A subset of animal miRNAs are produced from mirtrons, short hairpin introns whose splicing bypasses the normal nuclear processing of canonical miRNAs. Recent studies revealed novel, extended intramolecular dsRNA produced by defined transcription units in flies and mammals, termed hairpin RNAs (hpRNAs). Detailed biogenesis studies in Drosophila showed that hpRNAs are not merely long miRNAs, but are actually processed by a distinct biogenesis pathway that is related to the canonical RNA interference pathway. We compare and contrast the miRNA and hpRNA pathways in this review, and describe some of the key questions that the recognition of this novel pathway raises." @default.
- W2029185005 created "2016-06-24" @default.
- W2029185005 creator A5017906320 @default.
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- W2029185005 date "2008-09-15" @default.
- W2029185005 modified "2023-09-25" @default.
- W2029185005 title "The long and short of inverted repeat genes in animals: MicroRNAs, mirtrons and hairpin RNAs" @default.
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- W2029185005 doi "https://doi.org/10.4161/cc.7.18.6734" @default.
- W2029185005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2697033" @default.
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