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• W2029193570 abstract "High-shear wet granulation is commonly used in the pharmaceutical industry to improve powder properties for downstream processes such as tabletting. Granule growth, however, is difficult to predict because the process is sensitive to raw material properties and operating conditions. Development of process analytical technologies is encouraged by regulatory bodies to improve process understanding and monitor quality online. The primary technologies investigated for high-shear wet granulation monitoring include power consumption, near-infrared spectroscopy, Raman spectroscopy, capacitance measurements, microwave measurements, imaging, focused beam reflectance measurements, spatial filter velocimetry, stress and vibration measurements, as well as acoustic emissions. This review summarizes relevant research related to each of these technologies and discusses the challenges associated with each approach as a possible process analytical technology tool for high-shear wet granulation." @default.
• W2029193570 created "2016-06-24" @default.
• W2029193570 creator A5047012543 @default.
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• W2029193570 date "2014-09-01" @default.
• W2029193570 modified "2023-10-15" @default.
• W2029193570 title "A review of monitoring methods for pharmaceutical wet granulation" @default.
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• W2029193570 doi "https://doi.org/10.1016/j.ijpharm.2014.06.027" @default.
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