Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029199491> ?p ?o ?g. }
- W2029199491 endingPage "527" @default.
- W2029199491 startingPage "521" @default.
- W2029199491 abstract "Post-cardiothoracic surgery (CTS) complications (e.g. myocardial injury, renal dysfunction, atrial fibrillation) may occur as a result of enhanced systemic inflammation, perhaps provoked by an oxidative stress response. N-acetylcysteine (NAC) is a free radical scavenger antioxidant agent that may attenuate this physiologic response and reduce post-CTS complications. Thus, a meta-analysis was performed to help characterize the potential beneficial effects of perioperative NAC administration in patients undergoing CTS. A systematic literature search in MEDLINE, EMBASE and the Cochrane Library was conducted through April 2008. A search strategy using medical subject headings and text keywords was performed. Results are reported as odds ratios or weighted mean differences with accompanying 95% confidence intervals (CIs). Studies were pooled using a fixed-effect model. The primary outcomes included atrial fibrillation (AF), myocardial infarction (MI), stroke, acute kidney injury (AKI), need for renal replacement therapy (RRT), mortality and total hospital length-of-stay (LOS). Upon meta-analysis of 13 trials (n = 1338 subjects), the use of NAC appeared to statistically significantly lower the odds of developing post-CTS AF by 36% (95%CI 2–58%) (n = 6 studies). This corresponded to an 8% (1–15%) pooled risk difference and a number-needed-to-treat of 13. NAC did not appear to significantly alter any of the other meta-analysis endpoints. The exclusion of the study utilizing only oral NAC therapy and the study with lower internal validity did not affect the overall conclusions of our meta-analysis. Currently, the most compelling data for using NAC in CTS patients is in post-CTS AF prevention. However, additional, larger randomized controlled trials evaluating this and other postoperative complication endpoints are needed." @default.
- W2029199491 created "2016-06-24" @default.
- W2029199491 creator A5004120573 @default.
- W2029199491 creator A5004383707 @default.
- W2029199491 creator A5027444047 @default.
- W2029199491 creator A5028725861 @default.
- W2029199491 creator A5034742104 @default.
- W2029199491 creator A5061173220 @default.
- W2029199491 date "2009-03-01" @default.
- W2029199491 modified "2023-10-16" @default.
- W2029199491 title "Use of N-acetylcysteine to reduce post-cardiothoracic surgery complications: a meta-analysis" @default.
- W2029199491 cites W146410082 @default.
- W2029199491 cites W1534173372 @default.
- W2029199491 cites W1978339533 @default.
- W2029199491 cites W1980051680 @default.
- W2029199491 cites W1983626006 @default.
- W2029199491 cites W1985910546 @default.
- W2029199491 cites W1994185223 @default.
- W2029199491 cites W1998725093 @default.
- W2029199491 cites W2001325584 @default.
- W2029199491 cites W2002641335 @default.
- W2029199491 cites W2002681693 @default.
- W2029199491 cites W2011286038 @default.
- W2029199491 cites W2019064473 @default.
- W2029199491 cites W2019308310 @default.
- W2029199491 cites W2023263797 @default.
- W2029199491 cites W2041438931 @default.
- W2029199491 cites W2043898540 @default.
- W2029199491 cites W2045288779 @default.
- W2029199491 cites W2046633151 @default.
- W2029199491 cites W2053491289 @default.
- W2029199491 cites W2057533801 @default.
- W2029199491 cites W2061577428 @default.
- W2029199491 cites W2070418093 @default.
- W2029199491 cites W2072588990 @default.
- W2029199491 cites W2078856783 @default.
- W2029199491 cites W2090050226 @default.
- W2029199491 cites W2096382911 @default.
- W2029199491 cites W2109661386 @default.
- W2029199491 cites W2114094383 @default.
- W2029199491 cites W2118203609 @default.
- W2029199491 cites W2120795994 @default.
- W2029199491 cites W2121795261 @default.
- W2029199491 cites W2133482423 @default.
- W2029199491 cites W2138470527 @default.
- W2029199491 cites W2143077267 @default.
- W2029199491 cites W2146467367 @default.
- W2029199491 cites W2172245650 @default.
- W2029199491 cites W2204478813 @default.
- W2029199491 cites W2358368113 @default.
- W2029199491 cites W2411969659 @default.
- W2029199491 cites W290846248 @default.
- W2029199491 doi "https://doi.org/10.1016/j.ejcts.2008.11.027" @default.
- W2029199491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19147369" @default.
- W2029199491 hasPublicationYear "2009" @default.
- W2029199491 type Work @default.
- W2029199491 sameAs 2029199491 @default.
- W2029199491 citedByCount "85" @default.
- W2029199491 countsByYear W20291994912012 @default.
- W2029199491 countsByYear W20291994912013 @default.
- W2029199491 countsByYear W20291994912014 @default.
- W2029199491 countsByYear W20291994912015 @default.
- W2029199491 countsByYear W20291994912016 @default.
- W2029199491 countsByYear W20291994912017 @default.
- W2029199491 countsByYear W20291994912018 @default.
- W2029199491 countsByYear W20291994912019 @default.
- W2029199491 countsByYear W20291994912020 @default.
- W2029199491 countsByYear W20291994912021 @default.
- W2029199491 countsByYear W20291994912022 @default.
- W2029199491 countsByYear W20291994912023 @default.
- W2029199491 crossrefType "journal-article" @default.
- W2029199491 hasAuthorship W2029199491A5004120573 @default.
- W2029199491 hasAuthorship W2029199491A5004383707 @default.
- W2029199491 hasAuthorship W2029199491A5027444047 @default.
- W2029199491 hasAuthorship W2029199491A5028725861 @default.
- W2029199491 hasAuthorship W2029199491A5034742104 @default.
- W2029199491 hasAuthorship W2029199491A5061173220 @default.
- W2029199491 hasBestOaLocation W20291994911 @default.
- W2029199491 hasConcept C126322002 @default.
- W2029199491 hasConcept C127413603 @default.
- W2029199491 hasConcept C141071460 @default.
- W2029199491 hasConcept C156957248 @default.
- W2029199491 hasConcept C160022790 @default.
- W2029199491 hasConcept C164705383 @default.
- W2029199491 hasConcept C168563851 @default.
- W2029199491 hasConcept C2776478404 @default.
- W2029199491 hasConcept C2779161974 @default.
- W2029199491 hasConcept C2780645631 @default.
- W2029199491 hasConcept C31174226 @default.
- W2029199491 hasConcept C44249647 @default.
- W2029199491 hasConcept C500558357 @default.
- W2029199491 hasConcept C71924100 @default.
- W2029199491 hasConcept C78519656 @default.
- W2029199491 hasConcept C95190672 @default.
- W2029199491 hasConceptScore W2029199491C126322002 @default.
- W2029199491 hasConceptScore W2029199491C127413603 @default.
- W2029199491 hasConceptScore W2029199491C141071460 @default.
- W2029199491 hasConceptScore W2029199491C156957248 @default.