Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029203797> ?p ?o ?g. }
- W2029203797 endingPage "R314" @default.
- W2029203797 startingPage "R307" @default.
- W2029203797 abstract "Increasing evidence suggests there is a sex difference in opioid analgesia of pain arising from somatic tissue. However, the existence of a sex difference in visceral pain and opioid analgesia is unclear. This was examined in the colorectal distention (CRD) model of visceral pain in the current study. The visceromotor response (vmr) to noxious CRD was recorded in gonadally intact male and female rats. Subcutaneous injection of morphine dose-dependently decreased the vmr in both groups without affecting colonic compliance. However, morphine was significantly more potent in male rats than females. Because systemic morphine can act at peripheral tissue and in the central nervous system (CNS), the source of the sex difference in morphine analgesia was determined. The peripherally restricted μ-opioid receptor (MOR) antagonist naloxone methiodide dose-dependently attenuated the effects of systemic morphine. Systemic administration of the peripherally restricted MOR agonist loperamide confirmed peripherally mediated morphine analgesia and revealed greater potency in males compared with females. Spinal administration of morphine dose-dependently attenuated the vmr, but there was no sex difference. Intracerebroventricular administration of morphine also dose-dependently attenuated the vmr with significantly greater potency in male rats. The present study documents a sex difference in morphine analgesia of visceral pain that is both peripherally and supraspinally mediated." @default.
- W2029203797 created "2016-06-24" @default.
- W2029203797 creator A5024669370 @default.
- W2029203797 creator A5055828727 @default.
- W2029203797 creator A5071209059 @default.
- W2029203797 date "2006-08-01" @default.
- W2029203797 modified "2023-09-23" @default.
- W2029203797 title "Sex differences in morphine-induced analgesia of visceral pain are supraspinally and peripherally mediated" @default.
- W2029203797 cites W1485450669 @default.
- W2029203797 cites W1544768191 @default.
- W2029203797 cites W1555395950 @default.
- W2029203797 cites W1591789321 @default.
- W2029203797 cites W1795513906 @default.
- W2029203797 cites W1847479685 @default.
- W2029203797 cites W1876803907 @default.
- W2029203797 cites W1914841629 @default.
- W2029203797 cites W1964792919 @default.
- W2029203797 cites W1972332198 @default.
- W2029203797 cites W1974371245 @default.
- W2029203797 cites W1975662189 @default.
- W2029203797 cites W1980674774 @default.
- W2029203797 cites W1984247805 @default.
- W2029203797 cites W1985993861 @default.
- W2029203797 cites W1993136139 @default.
- W2029203797 cites W1995857317 @default.
- W2029203797 cites W2002184042 @default.
- W2029203797 cites W2002381450 @default.
- W2029203797 cites W2007855905 @default.
- W2029203797 cites W2009866955 @default.
- W2029203797 cites W2012094079 @default.
- W2029203797 cites W2012496546 @default.
- W2029203797 cites W2012758933 @default.
- W2029203797 cites W2014554266 @default.
- W2029203797 cites W2014786081 @default.
- W2029203797 cites W2016634891 @default.
- W2029203797 cites W2017336787 @default.
- W2029203797 cites W2017543502 @default.
- W2029203797 cites W2017962201 @default.
- W2029203797 cites W2018269104 @default.
- W2029203797 cites W2019836749 @default.
- W2029203797 cites W2021604137 @default.
- W2029203797 cites W2021759214 @default.
- W2029203797 cites W2026527037 @default.
- W2029203797 cites W2026595123 @default.
- W2029203797 cites W2027006870 @default.
- W2029203797 cites W2034279059 @default.
- W2029203797 cites W2044124335 @default.
- W2029203797 cites W2047865790 @default.
- W2029203797 cites W2051341512 @default.
- W2029203797 cites W2053732295 @default.
- W2029203797 cites W2058151042 @default.
- W2029203797 cites W2058903258 @default.
- W2029203797 cites W2059386136 @default.
- W2029203797 cites W2061041929 @default.
- W2029203797 cites W2062700118 @default.
- W2029203797 cites W2066899696 @default.
- W2029203797 cites W2067252745 @default.
- W2029203797 cites W2070479673 @default.
- W2029203797 cites W2073214521 @default.
- W2029203797 cites W2073313461 @default.
- W2029203797 cites W2073611645 @default.
- W2029203797 cites W2074097650 @default.
- W2029203797 cites W2076006196 @default.
- W2029203797 cites W2084737128 @default.
- W2029203797 cites W2088752653 @default.
- W2029203797 cites W2089686100 @default.
- W2029203797 cites W2095838310 @default.
- W2029203797 cites W2101631514 @default.
- W2029203797 cites W2107687698 @default.
- W2029203797 cites W2107767118 @default.
- W2029203797 cites W2112519377 @default.
- W2029203797 cites W2133848352 @default.
- W2029203797 cites W2137272726 @default.
- W2029203797 cites W2142249956 @default.
- W2029203797 cites W2156106895 @default.
- W2029203797 cites W2158491958 @default.
- W2029203797 cites W2163547524 @default.
- W2029203797 cites W2168132586 @default.
- W2029203797 cites W2337401271 @default.
- W2029203797 cites W2413794643 @default.
- W2029203797 cites W2466742365 @default.
- W2029203797 cites W4231089418 @default.
- W2029203797 cites W4327634952 @default.
- W2029203797 cites W89713122 @default.
- W2029203797 doi "https://doi.org/10.1152/ajpregu.00824.2005" @default.
- W2029203797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16556902" @default.
- W2029203797 hasPublicationYear "2006" @default.
- W2029203797 type Work @default.
- W2029203797 sameAs 2029203797 @default.
- W2029203797 citedByCount "68" @default.
- W2029203797 countsByYear W20292037972012 @default.
- W2029203797 countsByYear W20292037972013 @default.
- W2029203797 countsByYear W20292037972014 @default.
- W2029203797 countsByYear W20292037972015 @default.
- W2029203797 countsByYear W20292037972016 @default.
- W2029203797 countsByYear W20292037972017 @default.
- W2029203797 countsByYear W20292037972018 @default.
- W2029203797 countsByYear W20292037972019 @default.