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- W2029203960 endingPage "915" @default.
- W2029203960 startingPage "897" @default.
- W2029203960 abstract "Introduction: The P2X7 receptor (P2X7R) has an important role in inflammation and immunity, but until recently, clinical application has been limited by a lack of specific antagonists. Recent studies using P2X7R knockout mice and specific receptor antagonists have shown that the P2X7R is an important therapeutic target in inflammatory diseases. Areas covered: We have reviewed the current literature on the role of the P2X7R in inflammatory diseases, focusing on potential therapeutic applications of selective P2X7R antagonists as anti-inflammatory agents. Particular emphasis has been placed on the potential role of P2X7R in common inflammatory diseases. The latest developments in Phase I and II clinical trials of P2X7R antagonists are covered. Expert opinion: Recent studies using gene knockout mice and selective P2X7R antagonists suggest that P2X7R is a viable therapeutic target for inflammatory diseases. However, efficacious P2X7R antagonists for use in clinical studies are still at an early stage of development. Future challenges include: identifying potential toxicity and side effects of treatment, timing of treatment initiation and its duration in chronic inflammatory conditions, optimum dosage and development of a functional assay for P2X7R that would help to guide treatment." @default.
- W2029203960 created "2016-06-24" @default.
- W2029203960 creator A5031062920 @default.
- W2029203960 creator A5043815123 @default.
- W2029203960 creator A5080219500 @default.
- W2029203960 date "2011-04-21" @default.
- W2029203960 modified "2023-10-16" @default.
- W2029203960 title "A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases" @default.
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