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• W2029204462 abstract "The aim of the present study was to investigate the effect of antidepressant drugs (characterized by a different mechanism of action), administered jointly with the selective 5-HT6 receptor antagonist N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide (SB-399885), in the forced swim test in rats. All the compounds under study were given intraperitoneally in doses which did not shorten the immobility time of rats. Co-administration of SB-399885 (3 mg/kg) and imipramine (20 mg/kg), desipramine (20 mg/kg), bupropion (5 mg/kg) or moclobemide (20 mg/kg), produced significant anti-immobility action, whereas SB-399885 (3 mg/kg) given jointly with citalopram (20 mg/kg) did not affect immobility time. None of the compounds studied, given alone or jointly, increased the general activity of rats measured in the open field test. The obtained results indicate that the blockade of 5-HT6 receptors may facilitate the anti-immobility effect of imipramine, desipramine, bupropion or moclobemide in the forced swim test." @default.
• W2029204462 created "2016-06-24" @default.
• W2029204462 creator A5022670452 @default.
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• W2029204462 date "2008-03-01" @default.
• W2029204462 modified "2023-10-16" @default.
• W2029204462 title "The selective 5-HT6 receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats" @default.
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• W2029204462 doi "https://doi.org/10.1016/j.ejphar.2007.12.013" @default.
• W2029204462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18234190" @default.
• W2029204462 hasPublicationYear "2008" @default.
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