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• W2029205073 endingPage "1075" @default.
• W2029205073 startingPage "1069" @default.
• W2029205073 abstract "In the brain, L-lactate is produced by both neurons and astrocytes. There is no doubt that neurons use L-lactate as a supplementary fuel although the importance of this energy source is disputed. Irrespective of its caloric value, L-lactate might also have a signaling role in the brain. Here, we review several current hypotheses of L-lactate mediated signaling. Some proposed mechanisms require L-lactate entry into the neurons leading to a shift in ATP/ADP ratio or redox state. Others postulate interaction with either known receptor HCA1 (GPR81) or a novel, yet unidentified receptor. We argue that the sensitivity of any such mechanism has to match the concentration range of extracellular L-lactate, which is less than ~1.5 mmol/L under physiologic conditions. From that point of view, some of the proposed mechanisms require supraphysiologic levels of L-lactate and could be engaged during ischemia or seizures when L-lactate concentration rises dramatically. Currently, we do not know whether L-lactate production in the brain occurs in microdomains, which might create higher than average local concentrations. Nevertheless, it is clear that in the brain, as in the peripheral tissues, L-lactate is not only used as a source of energy but also acts as a signaling molecule." @default.
• W2029205073 created "2016-06-24" @default.
• W2029205073 creator A5052308829 @default.
• W2029205073 creator A5070435740 @default.
• W2029205073 creator A5070887523 @default.
• W2029205073 date "2015-04-29" @default.
• W2029205073 modified "2023-10-16" @default.
• W2029205073 title "Is L-Lactate a Novel Signaling Molecule in the Brain?" @default.
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• W2029205073 doi "https://doi.org/10.1038/jcbfm.2015.77" @default.
• W2029205073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4640281" @default.
• W2029205073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25920953" @default.
• W2029205073 hasPublicationYear "2015" @default.
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