Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029205210> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2029205210 endingPage "4388" @default.
- W2029205210 startingPage "4380" @default.
- W2029205210 abstract "An automated parallel analytical/preparative HPLC/MS workstation has been developed to increase the analysis speed for characterizing and purifying combinatorial libraries. The system incorporates two columns operated in parallel for both LC/MS analysis and preparative LC/MS purifications (a technique we have named “parallel Analyt/PrepLCMS”). Keys to the successful development of this system have been the design of a multiple sprayer IonSpray interface to support flows from multiple columns and the design of a valving configuration which is under complete software control for delivering the crude samples to the two HPLC columns from a single autosampler. In comparison with the conventional LC/MS systems, where compounds are analyzed sequentially (i.e., one at a time), our parallel Analyt/PrepLCMS system provides an important increase in sample throughput, especially critical in the field of combinatorial chemistry, where compound libraries are generated frequently in parallel arrays and require high-throughout analysis techniques. Minor hardware modifications to the HPLC system were made to facilitate parallel chromatography analyses. By incorporating fast chromatography and mass-based fraction collection on our new parallel Analyt/PrepLCMS system, we demonstrate that more than 200 compounds can be characterized per instrument per day, and more than 200 compounds can be purified per instrument per night. The concept, design, and applications of parallel HPLC/MS to combinatorial libraries are presented and discussed." @default.
- W2029205210 created "2016-06-24" @default.
- W2029205210 creator A5002672267 @default.
- W2029205210 creator A5026190023 @default.
- W2029205210 date "1998-09-03" @default.
- W2029205210 modified "2023-10-08" @default.
- W2029205210 title "Developments of a Fully Automated Parallel HPLC/Mass Spectrometry System for the Analytical Characterization and Preparative Purification of Combinatorial Libraries" @default.
- W2029205210 cites W2041719513 @default.
- W2029205210 cites W2092953114 @default.
- W2029205210 cites W2111139278 @default.
- W2029205210 cites W2155217549 @default.
- W2029205210 cites W2417396306 @default.
- W2029205210 cites W247726684 @default.
- W2029205210 doi "https://doi.org/10.1021/ac9805448" @default.
- W2029205210 hasPublicationYear "1998" @default.
- W2029205210 type Work @default.
- W2029205210 sameAs 2029205210 @default.
- W2029205210 citedByCount "98" @default.
- W2029205210 countsByYear W20292052102012 @default.
- W2029205210 countsByYear W20292052102013 @default.
- W2029205210 countsByYear W20292052102014 @default.
- W2029205210 countsByYear W20292052102018 @default.
- W2029205210 countsByYear W20292052102019 @default.
- W2029205210 countsByYear W20292052102020 @default.
- W2029205210 countsByYear W20292052102021 @default.
- W2029205210 countsByYear W20292052102022 @default.
- W2029205210 crossrefType "journal-article" @default.
- W2029205210 hasAuthorship W2029205210A5002672267 @default.
- W2029205210 hasAuthorship W2029205210A5026190023 @default.
- W2029205210 hasConcept C111919701 @default.
- W2029205210 hasConcept C149629883 @default.
- W2029205210 hasConcept C157764524 @default.
- W2029205210 hasConcept C162356407 @default.
- W2029205210 hasConcept C179998833 @default.
- W2029205210 hasConcept C185592680 @default.
- W2029205210 hasConcept C41008148 @default.
- W2029205210 hasConcept C43617362 @default.
- W2029205210 hasConcept C555944384 @default.
- W2029205210 hasConcept C67953723 @default.
- W2029205210 hasConceptScore W2029205210C111919701 @default.
- W2029205210 hasConceptScore W2029205210C149629883 @default.
- W2029205210 hasConceptScore W2029205210C157764524 @default.
- W2029205210 hasConceptScore W2029205210C162356407 @default.
- W2029205210 hasConceptScore W2029205210C179998833 @default.
- W2029205210 hasConceptScore W2029205210C185592680 @default.
- W2029205210 hasConceptScore W2029205210C41008148 @default.
- W2029205210 hasConceptScore W2029205210C43617362 @default.
- W2029205210 hasConceptScore W2029205210C555944384 @default.
- W2029205210 hasConceptScore W2029205210C67953723 @default.
- W2029205210 hasIssue "20" @default.
- W2029205210 hasLocation W20292052101 @default.
- W2029205210 hasOpenAccess W2029205210 @default.
- W2029205210 hasPrimaryLocation W20292052101 @default.
- W2029205210 hasRelatedWork W1967186235 @default.
- W2029205210 hasRelatedWork W2045348955 @default.
- W2029205210 hasRelatedWork W2052769075 @default.
- W2029205210 hasRelatedWork W2125564439 @default.
- W2029205210 hasRelatedWork W2352028719 @default.
- W2029205210 hasRelatedWork W2378667902 @default.
- W2029205210 hasRelatedWork W2584886384 @default.
- W2029205210 hasRelatedWork W2791088446 @default.
- W2029205210 hasRelatedWork W88892441 @default.
- W2029205210 hasRelatedWork W2134078163 @default.
- W2029205210 hasVolume "70" @default.
- W2029205210 isParatext "false" @default.
- W2029205210 isRetracted "false" @default.
- W2029205210 magId "2029205210" @default.
- W2029205210 workType "article" @default.