FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029207164> ?p ?o ?g. }

• W2029207164 endingPage "144" @default.
• W2029207164 startingPage "117" @default.
• W2029207164 abstract "Monoclonal antibodies (mAbs) can be used therapeutically by binding to molecular targets with high specificity. Therefore, they have excellent therapeutic applications in ophthalmology. This manuscript presents four aspects of the therapeutic use of mAbs in ophthalmology: the scientific rationale, the unique characteristics of selected mAbs, the current state-of-the-art application, and relevant therapeutic mAbs for future applications in ophthalmology. We identified in the literature various single-agent therapies that inhibit the following targets: tumor necrosis factor (TNF), epithelial growth factor receptor, vascular endothelial growth factor (VEGF) receptor, basic fibroblast growth factor receptor, platelet-derived growth factor, and cluster of differentiation antigens. The roles of all biochemical targets in ocular diseases were evaluated. Current and future mAbs against various cytokines were assessed for the treatment of ocular diseases. The medical literature showed the clinical benefits of mAbs for treating angiogenic and inflammatory ocular diseases. Two anti-VEGF mAbs, bevacizumab and ranibizumab, and three anti-TNF agents, infliximab, etanercept, and adalimumab, control ocular neovascularization and intraocular inflammation. Other mAbs such as rituximab, daclizumab, efalizumab, and alemtuzumab showed positive results in animal and early clinical studies and may represent useful adjuvant therapies for ocular lymphoma or ocular inflammation. Ranibizumab is the only FDA-approved therapy; for other mAbs the so-called off-label application remains the standard. Intravenous administration of mAbs has demonstrated acceptable toxicity profiles, while intraocular injection may decrease the chances of systemic complications and increase the amount of drug available to the retina and choroid. In conclusion, effective clinical use of mAbs in ophthalmology is more commonly seen in the field of angiogenic vitreoretinal and autoimmune inflammatory diseases. The challenge for the future is combining biologic therapies to improve the quality and duration of responses while diminishing side effects. The role of mAbs within ophthalmic treatments will be defined according to future clinical experience and the results of randomized clinical trials." @default.
• W2029207164 created "2016-06-24" @default.
• W2029207164 creator A5006309944 @default.
• W2029207164 creator A5020276182 @default.
• W2029207164 creator A5029838955 @default.
• W2029207164 creator A5039172141 @default.
• W2029207164 creator A5066255583 @default.
• W2029207164 creator A5088143348 @default.
• W2029207164 creator A5089531087 @default.
• W2029207164 creator A5090572481 @default.
• W2029207164 date "2009-03-01" @default.
• W2029207164 modified "2023-10-05" @default.
• W2029207164 title "Therapeutic monoclonal antibodies in ophthalmology" @default.
• W2029207164 cites W1181184325 @default.
• W2029207164 cites W12276332 @default.
• W2029207164 cites W123239899 @default.
• W2029207164 cites W140822034 @default.
• W2029207164 cites W1489873347 @default.
• W2029207164 cites W1498573244 @default.
• W2029207164 cites W1501964064 @default.
• W2029207164 cites W1522421496 @default.
• W2029207164 cites W1524996852 @default.
• W2029207164 cites W1529189929 @default.
• W2029207164 cites W1552605193 @default.
• W2029207164 cites W1552787667 @default.
• W2029207164 cites W1559170621 @default.
• W2029207164 cites W1577441858 @default.
• W2029207164 cites W1581683172 @default.
• W2029207164 cites W1599734874 @default.
• W2029207164 cites W1617854122 @default.
• W2029207164 cites W1647640594 @default.
• W2029207164 cites W171251970 @default.
• W2029207164 cites W1817465123 @default.
• W2029207164 cites W1833163659 @default.
• W2029207164 cites W184315270 @default.
• W2029207164 cites W1877964961 @default.
• W2029207164 cites W190750849 @default.
• W2029207164 cites W1914606342 @default.
• W2029207164 cites W1963128268 @default.
• W2029207164 cites W1963705625 @default.
• W2029207164 cites W1965259073 @default.
• W2029207164 cites W1968855023 @default.
• W2029207164 cites W1969144061 @default.
• W2029207164 cites W1969169427 @default.
• W2029207164 cites W1969988293 @default.
• W2029207164 cites W1970296191 @default.
• W2029207164 cites W1970421475 @default.
• W2029207164 cites W1970666585 @default.
• W2029207164 cites W1971456299 @default.
• W2029207164 cites W1971945408 @default.
• W2029207164 cites W19734096 @default.
• W2029207164 cites W1975689486 @default.
• W2029207164 cites W1979815217 @default.
• W2029207164 cites W1980152514 @default.
• W2029207164 cites W1980969801 @default.
• W2029207164 cites W1981970388 @default.
• W2029207164 cites W1982589114 @default.
• W2029207164 cites W1982590804 @default.
• W2029207164 cites W1982626297 @default.
• W2029207164 cites W1982794477 @default.
• W2029207164 cites W1985312132 @default.
• W2029207164 cites W1985419111 @default.
• W2029207164 cites W1985962931 @default.
• W2029207164 cites W1986387499 @default.
• W2029207164 cites W1986561345 @default.
• W2029207164 cites W1987522740 @default.
• W2029207164 cites W1988233478 @default.
• W2029207164 cites W198863258 @default.
• W2029207164 cites W1988849896 @default.
• W2029207164 cites W1989262657 @default.
• W2029207164 cites W1989990332 @default.
• W2029207164 cites W1991305397 @default.
• W2029207164 cites W1991843154 @default.
• W2029207164 cites W1991942320 @default.
• W2029207164 cites W1991963023 @default.
• W2029207164 cites W1992041797 @default.
• W2029207164 cites W1992051074 @default.
• W2029207164 cites W1993575340 @default.
• W2029207164 cites W1994022653 @default.
• W2029207164 cites W1994056390 @default.
• W2029207164 cites W1994157670 @default.
• W2029207164 cites W1996537616 @default.
• W2029207164 cites W1997106678 @default.
• W2029207164 cites W1999128907 @default.
• W2029207164 cites W1999247995 @default.
• W2029207164 cites W2000292756 @default.
• W2029207164 cites W2000329618 @default.
• W2029207164 cites W2001203080 @default.
• W2029207164 cites W2001685483 @default.
• W2029207164 cites W2001993565 @default.
• W2029207164 cites W2002488023 @default.
• W2029207164 cites W200629597 @default.
• W2029207164 cites W2008113035 @default.
• W2029207164 cites W2009559220 @default.
• W2029207164 cites W2010923786 @default.
• W2029207164 cites W2011046688 @default.
• W2029207164 cites W2012125135 @default.
• W2029207164 cites W2012881872 @default.

• next