FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2029210147> ?p ?o ?g. }

• W2029210147 endingPage "295" @default.
• W2029210147 startingPage "293" @default.
• W2029210147 abstract "A 78-year-old farmer presented with symptomless skin lesions for evaluation. Two years prior, he had developed idiopathic pulmonary fibrosis (IPF) and had been treated thereafter with oral prednisolone 20 mg/day and occasionally with colchicine 1 mg/day. On examination, erythematoviolaceous, slightly infiltrated plaques, measuring approximately 5 x 9 cm, rubbery in consistency, intermingled with pustules, sometimes eroded, with distinctive borders, were noted on the dorsum of both hands and on the extensor surface of both forearms. The lesions had developed over a 20-day period. The skin of these areas was atrophic or eroded with multiple ecchymoses (Fig. 1). The abnormal laboratory findings included an elevated white blood cell count of 17,100/mm3, with 79% neutrophils, 16% lymphocytes, and 5% monocytes, C-reactive protein of 33.15 mg/dL (normal, <0.8 mg/dL), and immunoglobulin G of 598 mg/dL (normal, 701-1545 mg/dL). Other blood and urine tests performed were within normal limits. The diagnosis of IPF was reconfirmed through radiology, high-resolution computed tomography, and spirometry, as well as bronchoscopy and bronchoalveolar lavage fluid analysis. Coexistence of presumptive pulmonary alternariosis was excluded. Hematoxylin and eosin stained sections of the excised cutaneous specimen showed focal ulceration of the epidermis adjacent to a mainly intradermal abscess cavity. Within the latter, remnants of a partly destroyed hair follicle were seen amongst degenerating polymorphonuclear leukocytes, as well as many histiocytes and a few Langhans-type multinucleated giant cells. Minute collections of polymorphonuclear leukocytes were seen in the adjacent epidermis. Periodic acid-Schiff (PAS) and Gomori's silver methenamine stains showed a multitude of broad branching fungal hyphae and large spores within the aforementioned cavity, both free and within the cytoplasm of giant cells (Fig. 2). Immunohistochemistry was performed by means of the alkaline phosphatase anti-alkaline phosphatase (APAAP) method. Sections showed that the infiltrate consisted of an almost equal number of B and T lymphocytes, whereas histiocytes and the few giant cells were labeled with anti-CD68 antibodies. Skin smears and biopsy specimens taken twice from all lesions were used for mycologic examination. Wet mounts revealed numerous, brownish, septate hyphae and ovoid Skin smears and biopsy specimens taken twice from all lesions were used for mycologic examination. Wet mounts revealed numerous, brownish, septate hyphae and ovoid structures. Biopsy material was plated on Sabourand's dextrose agar with cloramphenicol (0.05 mg/mL). After 7 days at 27 degrees C, dark, gray-white colonies with a dark brown underside appeared. Microscopic examination of the colonies revealed hyphae with typical conidia having transverse and longitudinal septa. Based on macroscopic and microscopic examination, the isolates were identified as Alternaria alternata (Fig. 3). Treatment with prednisolone was reduced to 10 mg/day and the patient received oral itraconazole (200 mg/day). This resulted in progressive improvement of alternariosis, and the lesions healed completely within 3 months, when treatment was interrupted. Two years later, there is no evidence of recurrence." @default.
• W2029210147 created "2016-06-24" @default.
• W2029210147 creator A5005488546 @default.
• W2029210147 creator A5007102305 @default.
• W2029210147 creator A5046824616 @default.
• W2029210147 creator A5067865162 @default.
• W2029210147 creator A5071372345 @default.
• W2029210147 date "2000-04-01" @default.
• W2029210147 modified "2023-09-26" @default.
• W2029210147 title "Cutaneous alternariosis in a patient with idiopathic pulmonary fibrosis" @default.
• W2029210147 cites W2017532117 @default.
• W2029210147 cites W2019660582 @default.
• W2029210147 cites W2098888190 @default.
• W2029210147 cites W2127183180 @default.
• W2029210147 cites W2140577905 @default.
• W2029210147 cites W4230706594 @default.
• W2029210147 doi "https://doi.org/10.1046/j.1365-4362.2000.00936.x" @default.
• W2029210147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10809981" @default.
• W2029210147 hasPublicationYear "2000" @default.
• W2029210147 type Work @default.
• W2029210147 sameAs 2029210147 @default.
• W2029210147 citedByCount "22" @default.
• W2029210147 countsByYear W20292101472012 @default.
• W2029210147 countsByYear W20292101472014 @default.
• W2029210147 countsByYear W20292101472015 @default.
• W2029210147 countsByYear W20292101472016 @default.
• W2029210147 crossrefType "journal-article" @default.
• W2029210147 hasAuthorship W2029210147A5005488546 @default.
• W2029210147 hasAuthorship W2029210147A5007102305 @default.
• W2029210147 hasAuthorship W2029210147A5046824616 @default.
• W2029210147 hasAuthorship W2029210147A5067865162 @default.
• W2029210147 hasAuthorship W2029210147A5071372345 @default.
• W2029210147 hasConcept C126322002 @default.
• W2029210147 hasConcept C142724271 @default.
• W2029210147 hasConcept C2776715498 @default.
• W2029210147 hasConcept C2777714996 @default.
• W2029210147 hasConcept C2777961210 @default.
• W2029210147 hasConcept C2780559512 @default.
• W2029210147 hasConcept C43100952 @default.
• W2029210147 hasConcept C70508372 @default.
• W2029210147 hasConcept C71924100 @default.
• W2029210147 hasConcept C74864618 @default.
• W2029210147 hasConcept C75786782 @default.
• W2029210147 hasConcept C77076574 @default.
• W2029210147 hasConcept C90924648 @default.
• W2029210147 hasConceptScore W2029210147C126322002 @default.
• W2029210147 hasConceptScore W2029210147C142724271 @default.
• W2029210147 hasConceptScore W2029210147C2776715498 @default.
• W2029210147 hasConceptScore W2029210147C2777714996 @default.
• W2029210147 hasConceptScore W2029210147C2777961210 @default.
• W2029210147 hasConceptScore W2029210147C2780559512 @default.
• W2029210147 hasConceptScore W2029210147C43100952 @default.
• W2029210147 hasConceptScore W2029210147C70508372 @default.
• W2029210147 hasConceptScore W2029210147C71924100 @default.
• W2029210147 hasConceptScore W2029210147C74864618 @default.
• W2029210147 hasConceptScore W2029210147C75786782 @default.
• W2029210147 hasConceptScore W2029210147C77076574 @default.
• W2029210147 hasConceptScore W2029210147C90924648 @default.
• W2029210147 hasIssue "4" @default.
• W2029210147 hasLocation W20292101471 @default.
• W2029210147 hasLocation W20292101472 @default.
• W2029210147 hasOpenAccess W2029210147 @default.
• W2029210147 hasPrimaryLocation W20292101471 @default.
• W2029210147 hasRelatedWork W2002605343 @default.
• W2029210147 hasRelatedWork W2078248128 @default.
• W2029210147 hasRelatedWork W2080831921 @default.
• W2029210147 hasRelatedWork W2135937020 @default.
• W2029210147 hasRelatedWork W2386587034 @default.
• W2029210147 hasRelatedWork W2410083040 @default.
• W2029210147 hasRelatedWork W2467719995 @default.
• W2029210147 hasRelatedWork W2513990951 @default.
• W2029210147 hasRelatedWork W2904839990 @default.
• W2029210147 hasRelatedWork W4280505963 @default.
• W2029210147 hasVolume "39" @default.
• W2029210147 isParatext "false" @default.
• W2029210147 isRetracted "false" @default.
• W2029210147 magId "2029210147" @default.
• W2029210147 workType "article" @default.