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• W202921030 endingPage "93" @default.
• W202921030 startingPage "71" @default.
• W202921030 abstract "A complete understanding of NGF function in the CNS does not exist. Instead, there is a collection of observations based on experiments conducted in the PNS and CNS, although more definitive results have come from experiments in the PNS. The conclusion that NGF is a neurotropic factor in the PNS biased experimental design and interpretation of results when a function for NGF in the CNS was sought. An example of design and interpretation bias is the very significant paper by Schwab et al. (1979), showing for the first time retrograde transport of NGF in cholinergic neurons. These authors entitled the manuscript “Nerve growth factor (NGF) in the CNS: absence of specific retrograde transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra”, documenting the expectation of retrograde transport in catecholamine neurons of the CNS, as in the PNS. Subsequent experiments, reviewed here, support a neurotrophic role for NGF in the CNS, although in the cholinergic rather than catecholaminergic system of CNS neurons." @default.
• W202921030 created "2016-06-24" @default.
• W202921030 creator A5015891464 @default.
• W202921030 creator A5022058940 @default.
• W202921030 creator A5025837253 @default.
• W202921030 creator A5055508729 @default.
• W202921030 creator A5072968010 @default.
• W202921030 date "1991-01-01" @default.
• W202921030 modified "2023-09-27" @default.
• W202921030 title "Nerve Growth Factor Function in the Central Nervous System" @default.
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