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• W2029214740 endingPage "157" @default.
• W2029214740 startingPage "143" @default.
• W2029214740 abstract "This study describes a novel analytical method permitting simultaneous HPLC-fluorimetric quantification of multiple (15) d- and l-amino acids, kynurenate, taurine and phosphoethanolamine (a marker of membrane integrity) in microdialysates of prefrontal cortex of freely-moving rats. Levels of GABA were elevated by the transporter inhibitor, nipecotic acid, and by the transaminase inhibitor, vigabatrine. Supporting a neuronal origin, they were decreased by the GABAB autoreceptor agonist, baclofen, yet unaffected by fluoroacetate which disrupts glial metabolism. Glutamate levels were elevated by the transporter inhibitor, l-trans-PDC, and mainly neuronal since they were not decreased by fluoroacetate, yet reduced by baclofen (which recruits GABAB receptors on glutamatergic terminals) and elevated by the NMDA receptor antagonist, dizocilpine. By contrast, levels of glutamine were reduced by l-trans-PDC. Consistent with glial origin, they were unaffected by baclofen, yet reduced by fluoroacetate. Administration of d-serine selectively increased its levels over l-serine, and vice versa. d-serine modestly decreased levels of glycine, which were enhanced by administration of glycine itself and of the glycine transporter-1 inhibitor, sarcosine. Kynurenate levels were increased by its precursor, kynurenine, an effect abolished by the amino-transferase inhibitor, amino-oxyacetate. Taurine and the energy drink, Red Bull®, selectively elevated levels of taurine, which were only slightly reduced by fluoroacetate. Finally, administration of NMDA increased levels of taurine, kynenurate and phosphoethanolamine, while reducing d-serine. These actions were abolished by the competitive NMDA receptor antagonist, CPP, which was inactive alone. This broad-based dialysis system should prove instructive for exploring actions of psychotropic drugs, and for characterising animal models of CNS disorders." @default.
• W2029214740 created "2016-06-24" @default.
• W2029214740 creator A5015680710 @default.
• W2029214740 creator A5017153877 @default.
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• W2029214740 creator A5041494494 @default.
• W2029214740 creator A5090363145 @default.
• W2029214740 date "2011-11-01" @default.
• W2029214740 modified "2023-10-16" @default.
• W2029214740 title "Simultaneous quantification of d- vs. l-serine, taurine, kynurenate, phosphoethanolamine and diverse amino acids in frontocortical dialysates of freely-moving rats: Differential modulation by N-methyl-d-aspartate (NMDA) and other pharmacological agents" @default.
• W2029214740 cites W120633781 @default.
• W2029214740 cites W1482769507 @default.
• W2029214740 cites W1519351707 @default.
• W2029214740 cites W1524872820 @default.
• W2029214740 cites W1565217806 @default.
• W2029214740 cites W1573412658 @default.
• W2029214740 cites W1585385261 @default.
• W2029214740 cites W1603845976 @default.
• W2029214740 cites W1604488260 @default.
• W2029214740 cites W1608133052 @default.
• W2029214740 cites W1696951087 @default.
• W2029214740 cites W1868733321 @default.
• W2029214740 cites W1914381346 @default.
• W2029214740 cites W1967257947 @default.
• W2029214740 cites W1971147659 @default.
• W2029214740 cites W1972018788 @default.
• W2029214740 cites W1972839309 @default.
• W2029214740 cites W1973272812 @default.
• W2029214740 cites W1977294596 @default.
• W2029214740 cites W1982876021 @default.
• W2029214740 cites W1985484802 @default.
• W2029214740 cites W1987452720 @default.
• W2029214740 cites W1987548555 @default.
• W2029214740 cites W1988282606 @default.
• W2029214740 cites W1989781329 @default.
• W2029214740 cites W1990164229 @default.
• W2029214740 cites W1990362020 @default.
• W2029214740 cites W1998678296 @default.
• W2029214740 cites W1999238951 @default.
• W2029214740 cites W2002331435 @default.
• W2029214740 cites W2002803706 @default.
• W2029214740 cites W2005580328 @default.
• W2029214740 cites W2005999426 @default.
• W2029214740 cites W2007393557 @default.
• W2029214740 cites W2008020964 @default.
• W2029214740 cites W2008277503 @default.
• W2029214740 cites W2008595762 @default.
• W2029214740 cites W2010469749 @default.
• W2029214740 cites W2013973531 @default.
• W2029214740 cites W2013976278 @default.
• W2029214740 cites W2014608077 @default.
• W2029214740 cites W2019353857 @default.
• W2029214740 cites W2020761570 @default.
• W2029214740 cites W2020952616 @default.
• W2029214740 cites W2021680546 @default.
• W2029214740 cites W2021950684 @default.
• W2029214740 cites W2022809683 @default.
• W2029214740 cites W2023057339 @default.
• W2029214740 cites W2025151334 @default.
• W2029214740 cites W2026526415 @default.
• W2029214740 cites W2029614868 @default.
• W2029214740 cites W2029932670 @default.
• W2029214740 cites W2032111040 @default.
• W2029214740 cites W2036573344 @default.
• W2029214740 cites W2038577949 @default.
• W2029214740 cites W2039809600 @default.
• W2029214740 cites W2052457877 @default.
• W2029214740 cites W2053099578 @default.
• W2029214740 cites W2058100756 @default.
• W2029214740 cites W2058965273 @default.
• W2029214740 cites W2061790070 @default.
• W2029214740 cites W2062298313 @default.
• W2029214740 cites W2063597569 @default.
• W2029214740 cites W2066830945 @default.
• W2029214740 cites W2067361016 @default.
• W2029214740 cites W2069776963 @default.
• W2029214740 cites W2070662771 @default.
• W2029214740 cites W2073570537 @default.
• W2029214740 cites W2074003417 @default.
• W2029214740 cites W2074907255 @default.
• W2029214740 cites W2075447398 @default.
• W2029214740 cites W2081811399 @default.
• W2029214740 cites W2082369948 @default.
• W2029214740 cites W2084299214 @default.
• W2029214740 cites W2087204472 @default.
• W2029214740 cites W2087688207 @default.
• W2029214740 cites W2088790808 @default.
• W2029214740 cites W2091501619 @default.
• W2029214740 cites W2094670942 @default.
• W2029214740 cites W2095511895 @default.
• W2029214740 cites W2097494446 @default.
• W2029214740 cites W2100346695 @default.
• W2029214740 cites W2103903531 @default.
• W2029214740 cites W2105056821 @default.
• W2029214740 cites W2106257034 @default.
• W2029214740 cites W2110754014 @default.
• W2029214740 cites W2116379394 @default.
• W2029214740 cites W2120276500 @default.

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