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- W2029218689 abstract "Metorphamide (MET) elicited a potent, dose-dependent analgesia and respiratory depression in mice and rabbits. MET induced-analgesia was naloxone reversible and potentiated by bestatin. Naloxonazine, a relatively selective mu 1 blocker, at certain dosage (50 micrograms per rabbit, icv), could abolish the analgesia but not the respiratory inhibition produced by MET. Our result indicates that mu 1 receptors mediate the MET induced-analgesia but not its respiratory effect. Since MET is a mu- and kappa-ligand with very low delta activity, the MET induced respiratory depression may be mediated by mu 2 or kappa binding sites." @default.
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- W2029218689 date "1985-04-01" @default.
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- W2029218689 title "The analgesic and respiratory depressant actions of metorphamide in mice and rabbits" @default.
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- W2029218689 doi "https://doi.org/10.1016/0143-4179(85)90103-9" @default.
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